Polymorphism
Racial disparities in the association between diabetes mellitus-associated polymorphic locus rs4430796 of the HNF1�² gene and prostate cancer: a systematic review and meta-analysis
Authors: Y.Z. Xiang, S.B. Jiang, J. Zhao, H. Xiong, Z.L. Cui, G.B. Li and X.B. Jin
Polymorphism 17q12 rs4430796 within HNF1β is a genetic variant associated with both diabetes mellitus and prostate cancer, but findings on the correlations of rs4430796 with prostate cancer risk specifically are not in agreement, especially among diverse populations. To shed some light on the contradictory findin.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.28.3
- DOI:
- 10.4238/2014.August.28.3
Relationship between EPHX2 gene polymorphisms and essential hypertension in Uygur, Kazakh, and Han
Authors: X.L. Zhu, L. Wang, Z. Wang, S.Z. Chen, W.Q. Zhang and M.M. Ma
We investigated the association between rs751141 polymorphisms in the EPHX2 gene and essential hypertension in Uygur, Kazakh, and Han subjects in Xinjiang, China. A total of 302 essential hypertensive patients in Uygur, 267 in Kazakh, and 368 in Han, as well as 323 normotensive controls in Uygur, 284 in Kazakh, and 348 in Han were enrolled in this study. .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.11
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.11
Regulators of G-protein signaling 9 genetic variations in Chinese subjects with schizophrenia
Authors: Y.S. Zhu, Y.X. Li, X.M. Qiao and H.B. Zhang
To identify single-nucleotide polymorphisms that contribute to the genetic susceptibility to schizophrenia, we examined the potential association between schizophrenia and 9 single nucleotide polymorphisms (rs1530351, rs4791230, rs2869577, rs8077696, rs8070231, rs2292592, rs9916525, rs1122079, and rs4790953) in the G-protein signaling 9 gene. The particip.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.13
- DOI:
- 10.4238/2015.July.28.13
Association between methionine synthase reductase A66G polymorphism and primary infertility in Chinese males
Authors: X.Y. Li, J.Z. Ye, X.P. Ding, X.H. Zhang, T.J. Ma, R. Zhong and H.Y. Ren
We examined the association between the methionine synthase reductase (MTRR A66G), methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), and methionine synthase (MS A2756G) genotypes and non-obstructive male infertility in a Chinese population. This case-control study included 162 infertile Chinese patients with azoospermia (N = 100) or oligoasthe.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.13
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.13
Polymorphisms in the methylene tetrahydrofolate reductase and methionine synthase reductase genes and their correlation with unexplained recurrent spontaneous abortion susceptibility
Authors: L. Zhu
We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes. A case control study was conducted in 118 patients with unexplained recurrent spontaneous abortion (abortion group) and 174 healthy women (control group.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.19
- DOI:
- 10.4238/2015.July.28.19
Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis
Authors: G.-C. Shi and L.-G. Zhang
We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.22
- DOI:
- 10.4238/2015.July.28.22
-173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population
Authors: Z.S. Wang, C.C. Yin, S. Han, F.L. Jiang, W.G. Guo, L.Q. Wu and S.H. Liu
In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.23
- DOI:
- 10.4238/2015.July.28.23
Association between five common polymorphisms in microRNA genes and the risk of gastric cancer: a meta-analysis
Authors: Y.P. Gu, Q.Y. Yuan, H. Zhang, C.J. Wang and F. Zhou
Gastric cancer (GC) is a prevalent disease with a high mortality rate, especially in developing countries. Accumulating evidence suggests that single nucleotide polymorphisms in microRNA (miRNA) genes might influence the susceptibility to GC; such sequence variation might contribute to the development of disease by altering crucial cellular pathways. In t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.4
- DOI:
- 10.4238/2015.July.28.4
Lack of association between an insertion/deletion polymorphism in IL1A and risk of colorectal cancer
Authors: H. Yan, R. Sun, X. Pan, Z. Li, X. Guo and L. Gao
Previous study has shown that miR-122, miR-378, and their target gene IL1A may play crucial roles in the tumorigenesis of colorectal cancer (CRC). An insertion/deletion polymorphism(rs3783553 TTCA/-) in the 3' untranslated region of IL1A has been identified as a contributing factor to the risk of developing several cancers. The aim of this study was to ev.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.17
- DOI:
- 10.4238/2015.July.28.17
Correlation of MSH3 polymorphisms with response and survival in advanced non-small cell lung cancer patients treated with first-line platinum-based chemotherapy
Authors: X.-L. Xu, Y.-L. Yao, W.-Z. Xu, J.-G. Feng and W.-M. Mao
Mismatch repair (MMR) genes, as well as the nucleotide excision repair genes, play an important role in removing cisplatin-DNA adducts, and the mutation of MMR genes in tumors can lead to a decreased response to platinum-based therapies. We examined MutS homolog 3 (MSH3), a mismatch repair gene, and whether polymorphisms of MSH3 were associated with respo.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.15.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.15.16