Multidrug Resistance
Mechanism of reversal of multidrug resistance by curcumin in human colorectal cancer cell line HCT-8/5-FU
Authors: Y.X. Fan, P. Abulimiti, H.L. Zhang, Y.K. Zhou and L. Zhu
Since there are no studies on the reversal of multidrug resistance by curcumin in the human colorectal cancer cell line HCT-8/5-FU, our aim was to search for highly efficient reversal agents and investigate the underlying mechanisms of this reversal. The cytotoxic effects of curcumin and 5-FU on HCT-8 and HCT-8/5-FU cells and .. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029414
- DOI:
- 10.4238/gmr16029414
Multidrug resistance gene (MDR1) polymorphisms may not be directly associated with response to imatinib in chronic myeloid leukemia
Authors: J.L. Wang, H.J. Liu, F. Li, W.Y. Yang, J.M. Wang, S.F. Tan and Q. Wang
Our study aimed to investigate the association between multidrug resistance (MDR1) gene polymorphisms and the response to imatinib (IM) in chronic myeloid leukemia (CML). An electronic databases in PubMed, Cochrane Library, Wanfang, China National Knowledge Infrastructure, and VIP were searched using combinations of k.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.24.4
- DOI:
- 10.4238/2015.November.24.4
MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients
Authors: F. Mahjoubi, S. Akbari, M. Montazeri and F. Moshyri
One of the main problems in treating cancer patients is that cancer cells can develop drug resistance. Resistance to multiple anticancer drugs, so called multidrug resistance (MDR), most likely involves a nonspecific mode of resistance, through drug-efflux transporters. One of the most extensively studied genes involved in MDR is multidrug resistance prot.. Read More»
- Genet. Mol. Res. 7(4):
- vol7-4gmr482
- DOI:
- 10.4238/vol7-4gmr482
Mechanism of the reversal effect of mifepristone on drug resistance of the human cervical cancer cell line HeLa/MMC
Authors: H. Chen, J. Duan and F. Zuo
We examined the ability of mifepristone to reverse the in vitro drug resistance of human cervical cancer cells resistant to mitomycin-C (HeLa/MMC) cells and investigated the mechanism of this effect. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed to detect the drug resistance of HeLa/MMC cel.. Read More»
- Genet. Mol. Res. 13(1):
- http://dx.doi.org/2014.February.27.14
- DOI:
- http://dx.doi.org/10.4238/2014.February.27.14
Isolation and characterization of cancer stem cells from medulloblastoma
Authors: J. Liu, N. Chi, J.Y. Zhang, W. Zhu, Y.S. Bian and H.G. Chen
Brain cancer stem cells are a subset of tumor cells present in several types of brain tumor that evade treatment regimens and are responsible for tumor recurrence. Recent reports on several tumors have suggested that Hoechst 33342 dye exclusion is a powerful technique for isolating cancer stem cell-like side population (SP) cells. In the present study, we.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.13.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.13.15
Reversal effect of vitamin D on different multidrug-resistant cells
Authors: M. Yan and H. Nuriding
We investigated the reversal effect of vitamin D on the multidrug-resistant leukemic Jurkat/ADR and K562/ADR cell lines and conducted a preliminary investigation of its reversal mechanism. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method was used to detect the reversal effect of vitamin D on multid.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.15.6
- DOI:
- 10.4238/2014.August.15.6
Effect of MDR1 polymorphism on multidrug resistance expression in breast cancer patients
Authors: M. Taheri, F. Mahjoubi and R. Omranipour
One of the limitations in the treatment of cancer patients with chemotherapy is the development of multidrug resistance (MDR). A well-known mechanism responsible for drug resistance is over-expression of ABC-transporter genes such as MDR1. This gene encodes p-glycoprotein (P-gp), a transmembrane glycoprotein that transports ma.. Read More»
- Genet. Mol. Res. 9(1):
- vol9-1gmr669
- DOI:
- 10.4238/vol9-1gmr669
Relationship between multidrug resistance 1 polymorphisms and the risk of prostate cancer in Chinese populations
Authors: F.R. Shen , C.Y. Yan, M. Liu, Y.H. Feng and Y.G. Chen
Prostate cancer is one of the most common malignancies in men. The multidrug resistance 1 gene (MDR1) is an important candidate gene for prostate cancer. The aim of this study was to evaluate the association between MDR1 gene polymorphisms and the risk of prostate cancer. MDR1 gene polymorphism and its association with the risk of prostate cancer were inv.. Read More»
- Genet. Mol. Res. 12(3):
- 2013.September.19.12
- DOI:
- 10.4238/2013.September.19.12
Overexpression of P-glycoprotein on fibroblast-like synoviocytes in refractory rheumatoid arthritis patients: a potential mechanism for multidrug resistance in rheumatoid arthritis treatment
Authors: Y.M. Liu, J.W. Chen, L.X. Chen, X. Xie and N. Mao
This study aims to investigate the role of P-glycoprotein (P-gp) expression level in drug resistance to disease-modifying anti-rheumatic drugs in refractory rheumatoid arthritis (RRA). We evaluated and compared the expression levels of P-gp in fibroblast-like synoviocyte (FLS) cells in patients with rheumatoid arthritis (RA) a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027927
- DOI:
- 10.4238/gmr.15027927