Hepatitis B
Hepatitis B and C prevalence and its associated risk factors among school going children in urban and rural areas of District Muzaffar Garh, Pakistan
Authors: Sikandar Hayat, Muhammad Naeem, Arif Malik, Qurban Ali, Muhammad Khalid, Samrah Masud and Arif Mahmood Bhutta
Viral Hepatitis like hepatitis B and hepatitis C are the serious cause of mortality in Pakistan. Present study estimated the prevalence and risk factors associated with Hepatitis B and C among school going children from urban and rural areas. In urban areas overall prevalence of HBV was 5% where the highest prevalence of HBV was 80% and 20% in males and f.. Read More»
- Genet. Mol. Res. 19(1):
Lack of association between human leukocyte antigen polymorphisms rs9277535 and rs7453920 and chronic hepatitis B in a Brazilian population
Authors: V.R.Z.B. Pereira, J.M. Wolf, G.Z. Stumm, T.R. Boeira, J. Galvan, D. Simon and V.R. Lunge
Hepatitis B virus (HBV) infection is a serious public health problem worldwide. The progression of the disease depends on several host and viral factors and may result in fulminant hepatitis (very rare), acute hepatitis with spontaneous clearance, and chronic hepatitis B infection. Previous studies demonstrated that variations.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029565
- DOI:
- 10.4238/gmr16029565
Construction and functional identification of a hepatitis B virus S protein small hairpin RNA recombinant adenovirus
Authors: S. Wang, Y.Z. Liu, D.D. Qin, C.C. Zou, Y.R. Sheng A.L. Huang and H. Tang
Hepatitis B virus S protein (HBs) plays an important role in hepatocellular carcinoma progression. However, to date, no direct and effective methods exist to research the function of HBs. Here, we combined the technology of RNA interference with recombinant adenovirus, constructed a recombinant adenovirus-expressing small hair.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.25.4
- DOI:
- 10.4238/2014.February.25.4
RANTES gene polymorphisms (-403G>A and -28C>G) associated with hepatitis B virus infection in a Saudi population
Authors: A. Al-Qahtani, S. Alarifi, M. Al-Okail, Z. Hussain4, A. Abdo, F. Sanai, M. Al-Anazi, N. Khalaf, H. Al-Humaidan, M. Al-Ahdal and F.N. Almajhdi
Besides the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. “Regulated on activation normal T-cell expressed and secreted” factor (RANTES) plays a vital role in CD4+, CD8+ T-lymphocyte and dendritic cell activation and proliferati.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.10.1
- DOI:
- 10.4238/2012.April.10.1
A large-scale analysis study on the clinical and viral characteristics of hepatitis B infection with concurrence of hepatitis B surface or E antigens and their corresponding antibodies
Authors: Y. Xiang, P. Chen, J.R Xia and L.P. Zhang
Concurrent detection of hepatitis B surface antigen (HBsAg) and anti-HBs antibody or hepatitis B surface E antigen (HBeAg) and anti-HBe antibody in patients with chronic hepatitis B (CHB) infection is well established. However, the clinical implications of these proteins remain largely unknown. In this study, demographic, clin.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019102
- DOI:
- 10.4238/gmr16019102
IL10 rs1800896 polymorphism is associated with liver cirrhosis and chronic hepatitis B
Authors: L.N. Cao1, S.L. Cheng2 and W. Liu3
We conducted a case-control study to assess the role of two IL10 gene polymorphisms (rs1800896 and rs1800872) in susceptibility to liver cirrhosis, and their association with chronic hepatitis B in a Chinese population. A case-control study was designed to investigate the association between functional polymorphisms of IL10 (rs1800896 and rs1800872) and t.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017256
- DOI:
- 10.4238/gmr.15017256
Efficacy and safety of nucleoside analogues in preventing vertical transmission of the hepatitis B virus from father to infant
Authors: L.-H. Cao,P.-L. Zhao,Z.-M. Liu,S.-C. Sun,D.-B. Xu,J.-D. Zhang,Z.-H. Shao
We examined the efficacy and safety of nucleoside analogues in preventing the vertical transmission of hepatitis B virus (HBV) from father to infant. We included 201 patients who visited the liver clinic of our hospital. The patients were positive for HBV surface antigen (HBsAg), HBeAg, anti-HBc, and HBV DNA; 189 patients (94%.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.4
- DOI:
- 10.4238/2015.December.1.4
Stable expression and integrated hepatitis B virus genome in a human hepatoma cell line
Authors: L.Y. Wang, Y.G. Li, K. Chen, K. Li, J.L. Qu, D.D. Qin and H. Tang
HepG2.2.15 cell is a widely used cell model for studying HBV (hepatitis B virus) in vitro. In these cells, the HBV genome is integrated in several sites of HepG2 cellular DNA. These multiple copies may have some influence on the cellular processes. We constructed a new plasmid, pSEH-Flag-HBV, and transfected it into HepG2 cell.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.18.3
- DOI:
- 10.4238/2012.May.18.3
Detection of serum anti-melanocyte antibodies and identification of related antigens in patients with vitiligo
Authors: M.C. Zhu,C.G. Liu, D.X. Wang,Z. Zhan
We detected autoantibodies against melanocytes in serum samples obtained from 50 patients, including 4 with HBV, with vitiligo and identified the associated membrane antigens. Heat shock protein 70 (HSP70) and anti-tyrosinase-related protein 1 (TRP-1) antibody levels were analyzed. The associated antigens in normal human melan.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.19
- DOI:
- 10.4238/2015.December.7.19
Functional polymorphisms in microRNA gene and hepatitis B risk among Asian population:a meta-analysis
Authors: G.Q. Zhou, H. Meng, J.R. Wang, F.X. Sun, X.J. Wang, R.B. Wang and X.B. Wang
Genetic mutations in microRNA gene can alter expression, which may interact to increase the risk of developing various diseases, including hepatitis B. However, published results are inconclusive or ambiguous. The aim of this review and meta-analysis is to more precisely estimate the association between polymorphisms in microRNA genes and hepatitis B risk.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.9
- DOI:
- 10.4238/2015.May.11.9