Hepatitis B
Identification of a mutation in Hepatitis B virus surface antigen capable of evading ELISA screening
Authors: Y. Cui, T. Zhang, Y. Yan and K. Liu
Hepatitis B virus (HBV) infection can cause HBV-related cirrhosis, liver failure, and hepatocellular carcinoma. At present, a hepatitis B surface antigen (HBsAg) blood test is the primary clinical and diagnostic marker for the identification of a chronic HBV infection. In the current study, we isolated a novel HBV mutant from a chronic HBV patient, capabl.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037582
- DOI:
- 10.4238/gmr.15037582
Changes in peripheral blood natural killer T cells in hepatitis B e antigen-positive chronic hepatitis B patients and efficacy prediction after pegylated interferon therapy
Authors: F. Huang, M.H. Lu, H.Y. Gong and Z.P. Xiong
We examined the expression of peripheral blood natural killer T (NKT) cells in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B (CHB) patients and predicted its efficacy after pegylated interferon a-2a (Peg-INFa-2a) therapy. Sixty-three cases of HbeAgpositive CHB inpatients and outpatients, treated in the Third Xiangya Hospital of Central South .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.11.26
- DOI:
- 10.4238/2015.May.11.26
Polymorphism of UGT1A1*28 (TA)7 and liver damage in hepatitis B virus-positive patients in Albania
Authors: E. Marku, P.E. Maltese, M. Koni, N. Capodicasa, I.S. Qendro, E. Rigoni, S. Cecchin and M. Bertelli
Hepatitis B virus (HBV) is the infectious agent of both acute and chronic hepatitis. HBV exists in multiple genotypic variants that differ in their capacity to become persistent chronic infections and in their clinical manifestations, including hepatocellular carcinoma. The 8 genotypes (A-H) of HBV show a specific worldwide geographic distribution and are.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.13
- DOI:
- 10.4238/2015.May.18.13
Blocking the expression of the hepatitis B virus S gene in hepatocellular carcinoma cell lines with an anti-gene locked nucleic acid in vitro
Authors: Y.-B. Deng, H.-J. Qin, Y.-H. Luo, Z.-R. Liang and J.-J. Zou
The aim of this study was to investigate the effects of inhibition of the hepatitis B virus (HBV) S gene by polypurine region locked nucleic acid on viral replication in cells. We designed and synthesized a locked nucleic acid, phosphorothioate oligonucleotides, unmodified oligonucleotides, and unrelated control sequence for the hepatitis B virus S gene p.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.22.14
- DOI:
- 10.4238/2015.May.22.14
Establishment of reference sequences of hepatitis B virus genotype C subgenotypes
Authors: H.L. Zhu, C.T. Wang, J.B. Xia, X. Li and Z.H. Zhang
Hepatitis B virus genotype C (HBV/C) has the largest number of subgenotypes (C1-C16) that vary with geography and isolates. HBV/C prevails in Southeast Asia (C1, C5-C16), East Asia (C2), Oceania (C3), and Australia (C4). Suitable reference strains for different subgenotypes could greatly facilitate research into HBV/C, but unfortunately they are scarce. W.. Read More»
- Genet. Mol. Res. 14(4):
- 2015
- DOI:
- 10.4238/2015
Reduced cortisol in the absence of bacterial infection in patients with hepatitis B virus cirrhosis
Authors: J. Zhang, H.-W. Yu, J. Li, Y.-K. Zhu, K.-F. Wang, L. Jia and Q.-H. Meng
In liver cirrhosis with bacterial infection, hepatoadrenal syndrome has been described recently as a progressive impairment in the adrenocortical reserve, with deficient production or action of glucocorticoids resulting in adrenal insufficiency. The aim of this study was to explore the characteristics of cortisol in hepatitis B virus (HBV) cirrhosis patie.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.17.3
- DOI:
- 10.4238/2015.July.17.3
An improved reverse dot hybridization for simple and rapid detection of adefovir dipivoxil-resistant hepatitis B virus
Authors: Y. Hu, W.L. Zhang, S.L. Xie, Y. Zhao, J.L. Hu, X.F. Cai, G.Q. Lai and A.L. Huang
Early detection of adefovir dipivoxil-resistant mutants during long-term treatment of chronic hepatitis B virus (HBV) infection with this drug is of great clinical importance. We developed an improved reverse dot hybridization test for simple and rapid detection of the rtA181V/T and rtN236T mutations associated with adefovir d.. Read More»
- Genet. Mol. Res. 11(1):
- http://dx.doi.org/2012.January.9.6
- DOI:
- http://dx.doi.org/10.4238/2012.January.9.6
-173G/C polymorphism in the promoter of MIF is associated with hepatitis B virus infection in a Chinese Han population
Authors: Z.S. Wang, C.C. Yin, S. Han, F.L. Jiang, W.G. Guo, L.Q. Wu and S.H. Liu
In addition to the host immune response, genetic and environmental factors play crucial roles in the manifestation of hepatitis B virus (HBV) infection. The macrophage migration inhibitory factor (MIF) -173G/C polymorphism (rs755622), located in the promoter region of MIF, may play integral roles in diverse processes, including the immune response. Thus, .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.23
- DOI:
- 10.4238/2015.July.28.23
Immune memory responses to HBV vaccine 13-18 years after primary vaccination
Authors: L. Hou, W. Li, X. Wei, Y. Zhou, Y. Zhuo, H. Wu, B. Shen
The aim of this study was to evaluate the immune memory response 13-18 years after an hepatitis B virus (HBV) vaccine by performing a specific in vitro stimulation experiment. Thirty healthy volunteers who had been inoculated 13-18 years ago with the HBV vaccine were collected from the physical examination center. Peripheral blood mononu.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.14
- DOI:
- 10.4238/2015.July.28.14
Role of IL-10 polymorphisms in susceptibility to hepatitis B virus-related hepatocellular carcinoma
Authors: M.W. Peng, S.Q. Lu, J. Liu and C.Y. Dong
We conducted a case-control study to investigate the role of three common single nucleotide polymorphisms of IL-10 (-592G/A, -819T/C, and -1082A/C) in the development of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). The study included 173 HBV-related HCC patients and 182 healthy controls. A polymerase chain r.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017984
- DOI:
- 10.4238/gmr.15017984