Hepatitis B
Synonymous codon selection in the hepatitis B virus translation initiation region
Authors: M.-R. Ma, L. Hui, M.-L. Wang, Y. Tang, Y.-W. Chang, Q.-H. Jia, X.-P. Yang, X.-H. Wang and X.-Q. Ha
Hepatitis B virus (HBV) infection is a major health problem worldwide. This virus and its hosts are often fated to continual co-evolutionary interactions. Codon usage analysis has significance for studies of co-evolution between viruses, their hosts, and mRNA translation. Adaptation of the overall codon usage pattern of HBV to that of humans is estimated .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.7.4
- DOI:
- 10.4238/2015.August.7.4
Immunomodulatory effect of bone marrow mesenchymal stem cells on T lymphocytes in patients with decompensated liver cirrhosis
Authors: C.H. Guo, L.X. Han, M.R. Wan, G.J. Deng and J.H. Gan
We explored the immunomodulatory effects of bone marrow mesenchymal stem cells (BMSCs) on peripheral blood T lymphocytes in patients with decompensation stage, hepatitis B-associated cirrhosis. MSCs from nine patients were analyzed by flow cytometry. Peripheral blood lymphocytes were isolated for fluorescent staining. Following stimulation by phytohemaggl.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.26.13
- DOI:
- 10.4238/2015.June.26.13
Evaluation of a histocompatibility antigen related to hepatitis B virus in patients with hepatocellular carcinoma in the western Brazilian Amazon
Authors: S.R.S. Chalub, R.M. da Silva, A.P.S. da Silva, P.F. de Aquino,A. Sadahiro and A.N. Kalil
Hepatocellular carcinoma is an infection of variable incidence that can be caused by hepatitis B virus (HBV), which is endemic in the Amazon region. The diagnosis of HBV can be performed through the use of serum markers such as the hepatitis B surface antigen. The chronic HBV can cause mutagenesis and carcinogenesis, being the susceptibility of infection .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.5
- DOI:
- 10.4238/2013.April.25.5
Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease
Authors: T.J. Xing, D.F. Jiang, J.X. Huang and Z.L. Xu
MicroRNA molecules have been increasingly regarded as a diagnostic and prognostic marker of certain diseases. The aim of this study was to investigate the expression and clinical significance of miR-122 and miR-29 in liver disease related to hepatitis B virus infection. The serum levels of miR-122 and miR-29 in 20 patients wit.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.4
- DOI:
- 10.4238/2014.September.29.4
Identifying significant pathways of hepatitis B virus-related hepatocellular carcinoma based on crosstalk and network pathways
Authors: L.M. Wen, W.Z. Wu and X.C. Peng
This study aims to identify significant pathways in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) based on the pathway network strategy. We proposed a pathway network where a protein-protein interaction (PPI) network was integrated with the crosstalk of pathways. Pathway data were first obtained from backgroun.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028343
- DOI:
- 10.4238/gmr.15028343
Antiviral effect of hepatitis B virus S/C gene loci antisense locked nucleic acid on transgenic mice in vivo
Authors: Y.B. Deng, H.J. Qin, Y.H. Luo, Z.R. Liang and J.J. Zou
We investigated the effects of hepatitis B virus (HBV) S/C double gene loci antisense locked nucleic acid on replication and expression of HBV in hepatitis transgenic mice. HBV mice (N = 30) were randomly divided into five groups of six mice: 5% glucose solution control, empty liposome control, single-target S, single-target C, and dual-target SC groups. .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.16
- DOI:
- 10.4238/2015.August.21.16
Correlation between hepatitis B virus DNA levels and diagnostic tests for HBsAg, HBeAg, and PreS1-Ag in chronic hepatitis B
Authors: X. Liu, J.M. Chen, J.L. Lou, Y.X. Huang, Y. Yan, G.Z. Sun and N. Li
he aim of this study was to investigate the diagnostic value of the serum markers HBsAg and HBeAg and PreS1 protein (PreS1-Ag) in quantifying the levels of hepatitis B virus (HBV) DNA in patients with chronic hepatitis B (CHB). One thousand CHB patients were recruited from Beijing You’an Hospital between June and Decembe.. Read More»
- Genet. Mol. Res. 15(2):