Gene
Inhibition of andrographolide in RAW 264.7 murine macrophage osteoclastogenesis by downregulating the nuclear factor-kappaB signaling pathway
Authors: Y.Q. Ren,Y.B. Zhou
This study aims to investigate the effects of andrographolide (AGP) on osteoclast formation in RAW 264.7 murine macrophage cells. The effects of AGP on cell viability were determined in RAW 264.7 cells using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The effects of AGP on osteoclast formation.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.7
- DOI:
- 10.4238/2015.December.7.7
Genome-wide identification and evolutionary analysis of nucleotide-binding site-encoding resistance genes in Lotus japonicus (Fabaceae)
Authors: H. Song, P.F. Wang,T.T. Li, H. Xia,S.Z. Zhao, L. Hou,C.Z. Zhao
Nucleotide-binding site (NBS) disease resistance genes play a crucial role in plant defense responses against pathogens and insect pests. Many NBS-encoding genes have been detected in Lotus japonicus, an important forage crop in many parts of the world. However, most NBS genes identified so far in L. japonicus were only partia.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.7.16
- DOI:
- 10.4238/2015.December.7.16
New microsatellite loci for the mandarin fish Siniperca chuatsi and their application in population genetic analysis
Authors: C.X. Tian, X.-F. Liang, M. Yang, Y.Q. Dou, H.Z. Zheng, L. Cao,Y.C. Yuan and C. Zhao
The mandarin fish is a popular fresh water food fish in China. Fifty-three polymorphic microsatellite markers were isolated through construction of an enriched library of genomic DNA of Siniperca chuatsi (Percichthyidae). We found 2 to 7 alleles per locus. The observed and expected heterozygosity values varied from 0.059 to 1... Read More»
- Genet. Mol. Res. 13(1):
- 2014.January.22.1
- DOI:
- 10.4238/2014.January.22.1
Biological analysis of chronic lymphocytic leukemia: integration of mRNA and microRNA expression profiles
Authors: L. Dong1, K.H. Bi1, N. Huang1 and C.Y. Chen2
Chronic lymphocytic leukemia (CLL) is a disease that involves progressive accumulation of nonfunctioning lymphocytes and has a low cure rate. There is an urgent requirement to determine the molecular mechanism underlying this disease in order to improve the early diagnosis and treatment of CLL. In this study, genes differentially expressed between CLL sam.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017170
- DOI:
- 10.4238/gmr.15017170
Recombinant expression and characterization of an endoglucanase III (cel12a) from Trichoderma harzianum (Hypocreaceae) in the yeast Pichia pastoris
Authors: W.C. Generoso, W. Malag�³-Jr., N. Pereira Jr. and F. Henrique-Silva
Filamentous fungi from the genus Trichoderma have been widely investigated due to their considerable production of important biotechnological enzymes. Previous studies have demonstrated that the T. harzianum strain IOC-3844 has a high degree of cellulolytic activity. After excluding the native signal peptide, the open reading .. Read More»
- Genet. Mol. Res. 11(2):
- dx.doi.org/2012.May.21.11
- DOI:
- dx.doi.org/10.4238/2012.May.21.11
Construction of gene/protein interaction networks for primary myelofibrosis and KEGG pathway-enrichment analysis of molecular compounds
Authors: C.G. Sun, X.J. Cao,C. Zhou, L.J. Liu, F.B. Feng, R.J. Liu, J. Zhuang,Y.J. Li
The objective of this study was the development of a gene/protein interaction network for primary myelofibrosis based on gene expression, and the enrichment analysis of KEGG pathways underlying the molecular complexes in this network. To achieve this, genes involved in primary myelofibrosis were selected from the OMIM database.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.1
- DOI:
- 10.4238/2015.December.8.1
Development and characterization of nine polymorphic microsatellites for the small brown planthopper Laodelphax striatellus (Hemiptera: Delphacidae)
Authors: J.-T. Sun, J.-B. Li, X.-M. Yang and X.-Y. Hong
Nine microsatellite loci were isolated from the genome of Laodelphax striatellus (Homoptera: Delphacidae) by constructing (TC)6(AC)5 and (AG)6(AC)5 compound SSR-enriched libraries using suppression-PCR procedures. These loci were found to be highly polymorphic, with 13 to 30 alleles per locus in the three populations that we i.. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.21.9
- DOI:
- 10.4238/2012.May.21.9
Intravarietal polymorphisms reveal possible common ancestor of native Schinus terebinthifolius Raddi populations in Brazil
Authors: J.V.C. Pinto1, B.A. Crispim2, A.A. Vasconcelos3, D. Geelen4, A.B. Grisolia2 and M.C. Vieira1
Schinus terebinthifolius Raddi is a perennial native from Atlantic forest. It is of high ecological plasticity and is used in traditional medicine. Based on promising reports concerning its bioactivity, it was included as a species of great interest for distribution through the National Health System. A number of agronomic studies to guide its crop produc.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017477
- DOI:
- 10.4238/gmr.15017477
CYP4F2 gene single nucleotide polymorphism is associated with ischemic stroke
Authors: H.-Q. Yan, Y. Yuan, P. Zhang, Z. Huang, L. Chang and Y.-K. Gui
The objective of this study was to explore the relationship between CYP4F2 gene polymorphism and ischemic stroke (IS) in the Han Chinese population. We performed a case-control study to genotype four single nucleotide polymorphisms (SNPs) (rs2108622, rs3093100, rs3093105, rs3093135) in the CYF4F2 gene. The genotype and haplotype distributions were compare.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.8
- DOI:
- 10.4238/2015.January.30.8
Identification of hub genes and pathways associated with retinoblastoma based on co-expression network analysis
Authors: Q.L. Wang, X. Chen, M.H. Zhang, Q.H. Shen, Z.M. Qin
The objective of this paper was to identify hub genes and pathways associated with retinoblastoma using centrality analysis of the co-expression network and pathway-enrichment analysis. The co-expression network of retinoblastoma was constructed by weighted gene co-expression network analysis (WGCNA) based on differentially ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.8.4
- DOI:
- 10.4238/2015.December.8.4