Gene
A novel frameshift deletion in the COL1A1 gene identified in a Chinese family with osteogenesis imperfecta
Authors: N. Fan, J.B. Jonas, F. He, N.H. Yan, Y. Wang, L. Liu, D.L. Liu, L. Zhao, I.-H. Pang and X.Y. Liu
Osteogenesis imperfecta (OI) is a genetically heterogeneous group of disorders, characterized by abnormal bone fragility, blue sclera, deafness, joint laxity, and soft-tissue dysplasia. The purpose of this study was to elucidate the genetic or molecular basis for OI type IA in a Chinese family. We evaluated the members of a fa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.5
- DOI:
- 10.4238/2015.November.30.5
Clinical and cytogenetic results of a series of amniocentesis cases from Northeast China: a report of 2500 cases
Authors: N. An, L.L. Li, R.X. Wang, L.L. Li, J.M. Yue and R.Z. Liu
The aims of this study were to demonstrate the clinical and cytogenetic results of amniocentesis (AS) cases in Northeast China, to compare the incidence of different kinds of chromosomal abnormalities, and to study the association between the detection rate of chromosomal abnormalities and different indications for prenatal di.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.1.18
- DOI:
- 10.4238/2015.December.1.18
Molecular characterization and expression patterns of insulin-like growth factor-binding protein genes in postnatal Nanjiang brown goats
Authors: S.Y. Zhan, L. Chen, L. Li, L.J. Wang, T. Zhong and H.P. Zhang
Insulin-like growth factor-binding proteins (IGFBPs) play a key role in modulating insulin-like growth factors (IGFs), and are considered candidate genes for growth traits in livestock. In this study, we identified the complete coding sequences of IGFBP-1 to -6 in the Nanjiang brown goat, and assessed gene tissue expression pa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.22
- DOI:
- 10.4238/2015.October.16.22
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism
Authors: E. Stur, L.P. Agostini, F.M. Garcia, G.T. Peterle, L.L. Maia,S.O. Mendes, Q.S. Anders, R.S. Reis, J.A. Santos, D.P. Ventorim, M.B. Carvalho, E.H. Tajara, M. Santos, F. Paula,A.M.A. Silva-Conforti and I.D. Louro
The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). Peripheral blood DNA was extracted .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.11
- DOI:
- 10.4238/2015.October.16.11
Significance of detecting IgH and TCR�³ gene rearrangements in patients with hemopoietic maligancies by real-time quantitative PCR
Authors: J. Yao, R.H. Wang, B. Li, Y. Wang, P. Zhu, X.J. Li, X.Q. Ma,M.J. Ma and L.F. Yin
The aim of our study was to investigate the association of IgH and TCRγ gene rearrangements in hematological malignancies with the disease and clinical application. IgH and TCRγ gene rearrangements were determined in 69 paraffin and bone marrow specimens with SYBR Green I fluorescent dye and RQ-PCR method, includin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.5
- DOI:
- 10.4238/2015.October.9.5
Strategies in identifying individuals in a segregant population of common bean and implications of genotype x environment interaction in the success of selection
Authors: M.P. Mendes, M.A.P. Ramalho and A.F.B. Abreu
The objective of this study was to compare the BLUP selection method with different selection strategies in F2:4 and assess the efficiency of this method on the early choice of the best common bean (Phaseolus vulgaris) lines. Fifty-one F2:4 progenies were produced from a cross between the CVIII8511 x RP-26 lines. A randomized .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.April.10.3
- DOI:
- 10.4238/2012.April.10.3
Comparative characteristics of DNA polymorphisms of �º-casein gene (CSN3) in the horse and donkey
Authors: Comparative characteristics of DNA polymorphisms of �º-casein gene (CSN3) in the horse and donkey
The aims of this study were to assess the genetic variability in the exon 1 of the κ-casein gene in four Italian horse populations (Italian Saddle horse, Italian Trotter, Italian Heavy Draught horse, and Murgese horse) and in a sample of Martina Franca donkey by estimating genotype, allele and haplotype frequencies, as well as several population gen.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.20
- DOI:
- 10.4238/2015.November.18.20
Characterization of HSP70 and its expression in tissue: correlation with physiological and immune indices in goose (Anser cygnoides) serum
Authors: W.W. Zhang, X. Xiao, J.K. Gan, X.Q. Zhang, L.N. Kong and Q.B. Luo
We cloned the goose heat shock protein 70 gene (HSP70), to determine its sequence variation and elucidate its mRNA expression. We designed primers to amplify the entire goose HSP70 sequence. We used 10 commercial Wuzong goslings in a heat-stress experiment. We collected tissue samples for RNA extraction and quantitative real-t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.17
- DOI:
- 10.4238/2015.October.9.17
Analysis of ITS1 sequences and genetic relationships between populations of ridgetail white prawn, Exopalaemon carinicauda, in the East China Sea
Authors: X.Z. Zhang, X.Q. Cheng, Y.X. Yu, H. Shen and X.H. Wan
Internal transcribed spacer 1 (ITS1) sequences from wild-type Exopalaemon carinicauda (N = 124) from the East China Sea were amplified and sequenced. Sequences were polymorphic and ranged from 388 to 583 bp in length. The average content of GC in sequences was significantly higher than that of AT. Altogether, 604 mutant sites .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.9.20
- DOI:
- 10.4238/2015.October.9.20
Genetic variation and genetic structure of the endangered species Sinowilsonia henryi Hemsi. (Hamamelidaceae) revealed by amplified fragment length polymorphism (AFLP) markers
Authors: H. Zhang, W.L. Ji, M. Li and L.Y. Zhou
Comprehensive research of genetic variation is crucial in designing conservation strategies for endangered and threatened species. Sinowilsonia henryi Hemsi. is a tertiary relic with a limited geographical distribution in the central and western areas of China. It is endangered because of climate change and habitat fragmentati.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.14.1
- DOI:
- 10.4238/2015.October.14.1