Gene
Determination of the potential of induced pluripotent stem cells to differentiate into mouse nucleus pulposus cells in vitro
Authors: K. Liu, Z. Chen, X.W. Luo, G.Q. Song, P. Wang, X.D. Li, M. Zhao,X.W. Han, Y.G. Bai, Z.L. Yang and G. Feng
We determined the potential for induced pluripotent stem (iPS) cells to differentiate into nucleus pulposus (NP)-like cells in mice. iPS cells were generated from tail-tip fibroblasts. We used a pellet culture model with the aim of determining the applicability of iPS cell-based therapy to intervertebral disc degeneration (IVD.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.6
- DOI:
- 10.4238/2015.October.16.6
Effect of Bcl-2-siRNA on proliferation and apoptosis of pediatric acute B lymphoblastic leukemia (A-BLL) cells
Authors: W.B. Meng, J.P. Liu, X.W. Wang and L.H. E
This study analyzed the effect of small interfering RNA specific for the Bcl-2 gene (siRNA Bcl-2) on the proliferation and chemotherapeutic sensitivity of pediatric A-BLL cells. Marrow samples were obtained from sixty newly-diagnosed A-BLL pediatric patients. The Bcl-2 mRNA expression in these samples was quantified by real ti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.9
- DOI:
- 10.4238/2015.October.16.9
Genetic divergence of physiological-quality traits of seeds in a population of peppers
Authors: A.M.S. Pessoa, P.A. Barroso, E.R. do R�ªgo, G.D.A. Medeiros, R.L.A. Bruno and M.M. do R�ªgo
Brazil has a great diversity of Capsicum peppers that can be used in breeding programs. The objective of this study was to evaluate genetic variation in traits related to the physiological quality of seeds of Capsicum annuum L. in a segregating F2 population and its parents. A total of 250 seeds produced by selfing in the F1 g.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.15
- DOI:
- 10.4238/2015.October.16.15
Elevated serum homocysteine level in the development of diabetic peripheral neuropathy
Authors: L.Q. Zheng, H.L. Zhang, Z.H. Guan, M.Y. Hu, T. Zhang and S.J. Ge
The development of diabetic peripheral neuropathy (DPN) is always followed by changes in vascular endothelial cells that are related to the reactivity of the homocysteine (Hcy) sulfhydryl group. In this meta-analysis, we investigated the association of Hcy with the pathogenesis and progression of DPN. We screened the Embase, O.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.14
- DOI:
- 10.4238/2015.November.30.14
Molecular characterization of tumor necrosis factor receptor-associated factor 6 (TRAF6) in pearl oyster Pinctada martensii
Authors: Y. Jiao, Q.L. Tian, X.D. Du, Q.H. Wang, R.L. Huang, Y.W. Deng and S.L. Shi
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a key signaling adaptor molecule for tumor necrosis factor receptor superfamily and Toll-like receptor/interleukin-1 receptor family members. It signals the upstream receptors and is involved in a wide range of biological functions, such as immunity and bone metabolism. In this report, the TRAF.. Read More»
- Genet. Mol. Res. 13(4):
- 2014.December.12.17
- DOI:
- 10.4238/2014.December.12.17
Analysis of gene expression patterns and levels in maize hybrids and their parents
Authors: H.S. Nie, S.P. Li, X.H. Shan, Y. Wu, S.Z. Su, H.K. Liu, J.Y. Han and Y.P. Yuan
Heterosis has greatly contributed to conventional plant breeding and is widely used to increase crop plant productivity. However, although some studies have explored the mechanisms of heterosis at the genomic and transcriptome level, these mechanisms still remain unclear. The growth and development of maize seedlings and immat.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.17
- DOI:
- 10.4238/2015.November.30.17
Evaluation of genetic divergence among clones of conilon coffee after scheduled cycle pruning
Authors: J.M. Dalcomo, H.D. Vieira, A. Ferreira, W.L. Lima, R.G. Ferr�£o, A.F.A. Fonseca, M.A.G. Ferr�£o and F.L. Partelli
Coffea canephora genotypes from the breeding program of Instituto Capixaba de Pesquisa e Extensão Rural were evaluated, and genetic diversity was estimated with the aim of future improvement strategies. From an initial group of 55 genotypes, 18 from the region of Castelo, ES, were selected, and three clones of .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.19
- DOI:
- 10.4238/2015.November.30.19
Association of the LMNA gene single nucleotide polymorphism rs4641 with dilated cardiomyopathy
Authors: J. Yin, J. Yang, F.X. Ren, C.M. Sun, L.D. Li, L.Y. Han, S.L. Cai, C.H. Zhang, Z.Q. Zhang, Z.T. Zhang and H. Wang
Recently, studies on the pathogenesis of dilated cardiomyopathy (DCM) have focused on the underlying molecular biology and the association between single nucleotide polymorphisms (SNPs) and disease. This study was designed to explore the association between the rs4641 SNP of the LMNA gene and DCM in order to identify a new gen.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.30.20
- DOI:
- 10.4238/2015.November.30.20
Genetic variations in the UTR of genes related to molting in Eriocheir sinensis
Authors: X.G. Gao, H.S. Pu, C.B. He, X.B. Bao and W.D. Liu
Crab grows by periodic molting, which is controlled by molt-inhibiting hormone (MIH) and ecdysteroids. Untranslated regions (UTRs) play crucial roles in the posttranscriptional regulation of gene expression. In this study, using crab collected from Changjiang (Yangtze), Huanghe (Yellow), Liaohe, and Yalujiang rivers, 33 haplot.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.14
- DOI:
- 10.4238/2015.October.16.14
Association of interleukin gene polymorphisms with the risk of coronary artery disease
Authors: H.T. Yang, S.L. Wang, L.J. Yan, P. Qian and H.Y. Duanb
We conducted a case-control study to investigate the genetic variants Interleukin-1β(IL-1β) +3953 C/T (rs1143634), IL-6 -174G/C (rs1800795), IL-8 -251T/A (rs4073), and IL-10 -1082A/G (rs1800896) and -819C/T (rs1800871) in the development of coronary artery disease (CAD). A total of 410 individuals with CAD were enrol.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.16.16
- DOI:
- 10.4238/2015.October.16.16