Gene
Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells
Authors: J.X. Chen, G.Y. Cai, X.M. Chen, H. Liu, X. Chen, Y.M. Peng, F.Y. Liu, Z. Li and S.Z. Shi
To explore the role of metalloproteinase-1 (TIMP-1) tissue inhibitor in the mechanisms of kidney aging, we observed the effects of sense and antisense transfection of TIMP-1 and of metalloproteinase (MMP) inhibitors on phosphatase and tensin homolog (PTEN), vascular endothelial growth factor (VEGF), and Flk-1 expression in TIMP-1 transgenic human proximal.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.6
- DOI:
- 10.4238/2015.December.21.6
A novel TSC1 mutation (c.1964delA) in a Chinese patient with tuberous sclerosis complex
Authors: G.-X. Wang, D.-W. Wang, J.-S. Zhao, S.-F. Wang and R.-P. Sun
Tuberous sclerosis complex is an autosomal-dominant heritable disease caused by mutations in the TSC1 and TSC2 genes. We studied a Chinese patient with sporadic tuberous sclerosis complex. The clinical features of this patient included epilepsy, hypomelanotic macules and angiofibromas on his back; a cranial CT scan showed sube.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr977
- DOI:
- 10.4238/vol10-1gmr977
Molecular and chemical characterization of vetiver, Chrysopogon zizanioides (L.) Roberty, germplasm
Authors: R.S. Celestino, M.I. Zucchi, J.B. Pinheiro, J.B. Campos, A.A. Pereira, F.G. Bianchini, R.N. Lima, M.F. Arrigoni-Blank, P.B. Alves and A.F. Blank
Due to the economic interests in vetiver, Chrysopogon zizanioides (L.) Roberty, molecular and chemical studies are essential to generate information for its sustainable exploitation. The aim of this study was to undertake a molecular and chemical characterization of vetiver accessions of the active germplasm bank of the Universidade Federal de Sergipe. Th.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.9
- DOI:
- 10.4238/2015.August.14.9
Estimation of genetic distance based on RAPDs between 11 cotton accessions varying in heat tolerance
Authors: A.I. Khan, I.A. Khan, F.S. Awan, H.A. Sadaqat and S. Bahadur
The genetic distance of 11 cotton genotypes varying in heat tolerance was studied using RAPD markers. Fifty-three random decamer primers were used for the estimation of genetic distance. Among the 53 RAPD primers, which were custom synthesized by GeneLink Inc., UK, 32 were polymorphic and 21 were monomorphic. The 32 polymorphi.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr835
- DOI:
- 10.4238/vol10-1gmr835
C/EBP�± gene as a genetic marker for beef quality improvement
Authors: C. Adoligbe, Y.F. Huangfu, L.S. Zan and H. Wang
Intramuscular fat (IMF) or intramuscular triglycerides are interspersed throughout the skeletal muscles. The IMF, also called marbling, imparts meat with flavor and juiciness and is one of the core criteria for judging carcass value. The quantity of IMF is influenced entirely by genetics. Recently, understanding the underlying genetic bases of IMF has bee.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.1
- DOI:
- 10.4238/2015.August.14.1
Association of the VRK2 gene rs3732136 polymorphism with schizophrenia in a Northwest Chinese Han population
Authors: B. Zhang, C.Y. Gao, H.B. Zhang, B. Yang, J.F. Yin, S.G. Wei, Y.S. Zhu, X.N. Jia and S.B. Li
Previous studies have found that the vaccinia related kinase 2 gene (VRK2) polymorphism was associated with schizophrenia (SCZ) in the worldwide population. This association was further supported by VRK2 mRNA expression patterns and brain structure variations. Here, we analyzed four single nucleotide polymorphisms (SNPs) of the VRK2 gene in a total popula.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.4
- DOI:
- 10.4238/2015.August.14.4
Cancer classification based on gene expression using neural networks
Authors: H.P. Hu, Z.J. Niu, Y.P. Bai and X.H. Tan
Based on gene expression, we have classified 53 colon cancer patients with UICC II into two groups: relapse and no relapse. Samples were taken from each patient, and gene information was extracted. Of the 53 samples examined, 500 genes were considered proper through analyses by S-Kohonen, BP, and SVM neural networks. Classification accuracy obtained by S-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.33
- DOI:
- 10.4238/2015.December.21.33
Effect of transcription factor ZBTB20 on mouse pituitary development
Authors: Q. Dong, X.Y. Chen and G.M. Li
Pituitary, a critical component in the neuroendocrine system, plays an indispensable role in the regulation of body growth. The transcriptional factor ZBTB20 is widely expressed in brain tissues and participates in hippocampal development; however, the detailed molecular mechanism remains unknown. Therefore, the aim of this study was to investigate the ef.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.35
- DOI:
- 10.4238/2015.December.21.35
Genetic polymorphisms of the FATP1 gene and their associations with meat quality traits in Chinese Qinchuan cattle
Authors: Z.D. Zhao, A.N. Li, S.J. Wei, M.M. Wang, S.J. Li and L.S. Zan
Fatty acid transport protein 1 (FATP1), an integral membrane protein that facilitates long-chain fatty acid influx, is involved in the genetic network for oleic acid synthesis. The aim of this study was to examine the association of FATP1 polymorphisms with live animal meat quality traits in Chinese Qinchuan cattle. Quantitative real-time PCR analysis dem.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.14
- DOI:
- 10.4238/2015.December.21.14
Genetic diversity and structure of native and non-native populations of the endangered plant Pinus dabeshanensis
Authors: Z.Y. Zhang, H. Wang, W. Chen, X.M. Pang and Y.Y. Li
Owing to a severe decline in its abundance, Pinus dabeshanensis has been listed as an endangered species by the International Union for the Conservation of Nature. Although several restoration events have been undertaken since the 1960s, the natural population genetic structure of this species remains to be investigated. Herei.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027937
- DOI:
- 10.4238/gmr.15027937