Gene
Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil
Authors: C.M.A.R. Barros, A.P. Araujo-Neto, T.R. Lopes, M.A.L. Barros, F.J.N. Motta, R. Canalle, L.C.C. Nunes, J.A. Rey, R.R. Burbano, M.A. Lima-Barros, F.K.N. Yoshioka and G.R. Pinto
Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have dem.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.1
- DOI:
- 10.4238/2014.September.29.1
Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis
Authors: L.N. Xu, N. Lin, B.N. Xu, J.B. Li and S.Q. Chen
The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.2
- DOI:
- 10.4238/2015.December.11.2
Distribution of constitutive heterochromatin in Triatoma melanocephala (Hemiptera, Triatominae)
Authors: K.C.C. Alevi, J.A. Rosa and M.T.V. Azeredo-Oliveira
In principle, Triatoma melanocephala was included in the Brasiliensis subcomplex on the basis of morphological parameters and geographical layout, since there were no other relevant data available in the literature. On the basis of karyotype, it has been proposed to exclude T. melanocephala, as well as of .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.2
- DOI:
- 10.4238/2014.September.29.2
Screening for key genes associated with invasive ductal carcinoma of the breast via microarray data analysis
Authors: J.L. Huan, X. Gao, L. Xing, X.J. Qin, H.X. Qian, Q. Zhou and L. Zhu
The aim of this study was to identify key genes related to invasive ductal carcinoma (IDC) of the breast by analyzing gene expression data with bioinformatic tools. Microarray data set GSE31138 was downloaded from Gene Expression Omnibus, including 3 breast cancer tissue samples and 3 normal controls. Differentially expressed .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.5
- DOI:
- 10.4238/2014.September.29.5
Multi-threading the generation of Burrows-Wheeler Alignment
Authors: H. Jo
Along with recent progress in next-generation sequencing technology, it has become easier to process larger amounts of genome sequencing data at a lower cost. The most time-consuming step of next-generation sequencing data analysis involves the mapping of read data into a reference genome. Although the Burrows-Wheeler Alignmen.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028650
- DOI:
- 10.4238/gmr.15028650
Molecular characterization and functional analysis of the Nep1-like protein-encoding gene from Phytophthora capsici
Authors: B.Z. Feng and P.Q. Li
Phytophthora capsici is an aggressive plant pathogen that affects solanaceous and cucurbitaceous hosts. Nep1-like proteins (NLPs) are a group of effectors found particularly in oomycetes and considered important virulence factors. We identified an NLP gene (phcnlp1) from the highly virulent P. capsici strain Phyc12 that had an encoded polypeptide of 476-a.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.8
- DOI:
- 10.4238/2013.April.26.8
Dietary glycerol for quail: association between productive performance and COX III mRNA expression
Authors: S.C.C. Silva, E. Gasparino, E. Batista, F. Tanamati, A.P.D. Vesco, B. Lala and D.P. de Oliveira
This study was carry out to evaluate mRNA expression of mitochondrial cytochrome c oxidase III in the Pectoralis superficialis muscle of 28-day-old quails fed diets containing 0, 8, and 12% glycerol. Total RNA was extracted (N = 10) and cDNA was amplified using specifics primers for qRT-PCR. Feed efficiency and feed intake wer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027435
- DOI:
- 10.4238/gmr.15027435
Cloning and sequence analysis of the LOC339524 gene in Sprague-Dawley rats
Authors: Z.H. Long, H. Li, F. Chen and L.Y. Zou
We cloned the LOC339524 gene in Sprague-Dawley (SD) rats and analyzed the structure and function of the protein encoded by it. Based on the known human LOC339524 gene sequences, the full-length coding sequence of the LOC339524 gene in SD rats was cloned and amplified by the polymerase chain reaction using the complementary DNA of SD rats as a template. Bi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.4
- DOI:
- 10.4238/2015.December.11.4
Estimation of genetic parameters for growth traits in a breeding program for rainbow trout (Oncorhynchus mykiss) in China
Authors: G. Hu, W. Gu, Q.L. Bai and B.Q. Wang
Genetic parameters and breeding values for growth traits were estimated in the first and, currently, the only family selective breeding program for rainbow trout (Oncorhynchus mykiss) in China. Genetic and phenotypic data were collected for growth traits from 75 full-sibling families with a 2-generation pedigree. Genetic parameters and breeding values for.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.7
- DOI:
- 10.4238/2013.April.26.7
Effect of CYP1A1 and GSTM1 genetic polymorphisms on bone tumor susceptibility
Authors: L. Li, J.G. Li, C.Y. Liu and Y.J. Ding
Tumor gene polymorphisms are often associated with individual susceptibility to genetic diseases. Cytochrome P4501A1 (CYP1A1) and glutathione S-transferase mu 1 (GSTM1) gene polymorphisms are closely related to the susceptibility of the body to chemical carcinogens in the environment. Therefore, we explored the relationship between CYP1A1 and GSTM1 gene p.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.7
- DOI:
- 10.4238/2015.December.11.7