Gene
Gene expression study related with the intrinsic pathway of apoptosis in bladder cancer by real-time PCR technique
Authors: D.F. Barione, F.S.N. Lizarte, P.C. Novais, C.A.M. de Carvalho, F.C.B. Valeri, F.M. Peria, H.F. de Oliveira, D.L. Zanette, W.A. Silva Jr., A.J. Cologna, R.B. Reis, S. Tucci Jr., A.C.P. Martins, D.P.C. Tirapelli and L.F. Tirapelli
We examined the expression of anti-apoptotic genes (XIAP and Bcl-2) and apoptotic genes (cytochrome c, caspase-9, Apaf-1) in tissue samples of patients with superficial bladder cancer. Thirty-two bladder cancer tissue samples (8 papillary urothelial neoplasm of low malignant potential, 10 low-grade, and 14 high-grade) and 8 normal bladder tissue samples f.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.4
- DOI:
- 10.4238/2013.April.2.4
Association between a point mutation at the -743-bp region of the transthyretin (TTR) gene and familial vitreous amyloidosis
Authors: X.M. Nie, S.J. Cai, B. Xie, X.W. Chen and M. Jiang
The aim of this study was to identify changes in the base sequence of the upstream regulatory region of the transthyretin (TTR) gene. Whole-blood DNA was extracted from ten subjects belonging to a family with familial amyloidosis vitreoretinopathy; the upstream regulatory sequence was amplified by polymerase chain reaction, detected by gel electrophoresis.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016926
- DOI:
- 10.4238/gmr.15016926
Association of cytokine gene polymorphisms with susceptibility to invasive candidiasis
Authors: R.T. Sun, W.J. Tian, X.W. Xing, S.H. Gao and S.B. Wang
The aim of this study was to investigate the role of cytokine genes in the susceptibility to Candida infection. A total of 275 consecutive patients diagnosed with Candida infection were selected between May 2010 and May 2011, along with 305 uninfected controls. Genotyping of the IL-1β gene polymorphisms (IL1β) rs1143634, IL1β rs16944, IL8 r.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.29
- DOI:
- 10.4238/2015.June.18.29
Effect of two single nucleotide polymorphisms on milk yield and composition
Authors: J.C. Rinc�³n, A. L�³pez-Herrera and J.J. Echeverri
The bovine prolactin (PRL) and bovine growth hormone (bGH) genes exhibit several polymorphisms. Some of them can be detected by molecular techniques using restriction endonucleases, such as RsaI for the PRL gene and MspI for the bGH gene. We examined the relationship between the PRL-RsaI and bGH-MspI polymorphisms and some economically important character.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.15
- DOI:
- 10.4238/2013.April.2.15
Intracranial aneurysm risk factor genes:relationship with intracranial aneurysm risk in a Chinese Han population
Authors: L.T. Zhang, F.J. Wei, Y. Zhao, Z. Zhang, W.T. Dong, Z.N. Jin, F. Gao, N.N. Gao, X.W. Cai, N.X. Li, W. Wei, F.S. Xiao, S.Y. Yue, J.N. Zhang, S.Y. Yang, W.D. Li and X.Y. Yang
Few studies have examined the genes related to risk factors that may contribute to intracranial aneurysms (IAs). This study in Chinese patients aimed to explore the relationship between IA and 28 gene loci, proven to be associated with risk factors for IA. We recruited 119 patients with aneurysms and 257 controls. Single factor and logistic regression mod.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.18.30
- DOI:
- 10.4238/2015.June.18.30
Genetic analysis of differentiation of T-helper lymphocytes
Authors: Q. Wang, M. Li, L.C. Xia, G. Wen, H. Zu and M. Gao
In the human immune system, T-helper cells are able to differentiate into two lymphocyte subsets: Th1 and Th2. The intracellular signaling pathways of differentiation form a dynamic regulation network by secreting distinctive types of cytokines, while differentiation is regulated by two major gene loci: T-bet and GATA-3. We developed a system dynamics mod.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.13
- DOI:
- 10.4238/2013.April.2.13
Cytogenetic analysis of Triatoma pseudomaculata CorrÃ?ªa and EspÃ?Ânola, 1964 (Hemiptera, Triatominae) from different Brazilian states
Authors: C.H.L. Imperador, K.C.C. Alevi, J. Oliveira, J.A. Rosa and M.T.V. Azeredo-Oliveira
Triatoma maculata and T. pseudomaculata are allopatric; however, it is believed that T. maculata was introduced into the Brazilian northeast by passive transportation of the nymphs between the feathers of migratory birds, followed by the speciation of T. pseudomaculata. T. pseudomaculata is the second most epidemiologically important species in the northe.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15016937
- DOI:
- 10.4238/gmr.15016937
Polymorphisms of the myostatin gene (MSTN) and its relationship with growth traits in goat breeds
Authors: Z.J. Zhang, Y.H. Ling, L.J. Wang, Y.F. Hang, X.F. Guo, Y.H. Zhang, J.P. Dingand X.R. Zhang
Mutations in the myostatin (MSTN) gene can inactivate its expression and result in a non-functional protein, which leads to dramatic muscularity and a “double-muscling” phenomenon in many species. Using gene sequencing and polymerase chain reaction-single-strand conformation polymorphism methods, polymorphisms of the MSTN gene were investigate.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.12
- DOI:
- 10.4238/2013.April.2.12
In silico analysis of diverse endophytic fungi by using ITS1-5,8S-ITS2 sequences with isolates from various plant families in Brazil
Authors: S.A. Rhoden, A. Garcia, J.L. Azevedo and J.A. Pamphile
Brazil has a great diversity of plants, and considering that all plant species studied to date have endophytic microorganisms (bacteria or fungi), the country is a resource in the search for bioactive compounds. Endophytes live within plants without causing damage and may be in dynamic equilibrium with the health of the plant. Endophytic fungi can be iden.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.2.10
- DOI:
- 10.4238/2013.April.2.10
Genetic variability in Blanco Orejinegro breed cattle populations in Colombia
Authors: R. MartÃ?Ânez, A.P. LlinÃ?¡s and J.F. M.-Rocha
We analyzed population structure and genetic diversity in Blanco Orejinegro Creole cattle with 12 microsatellite markers, genotyping 138 individuals belonging to 7 commercial and 3 conservation herds. These markers showed a high level of polymorphism; 171 alleles were identified. The mean number of alleles per locus was 5.63 (3.82-6.58). The total number .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.10.4
- DOI:
- 10.4238/2013.April.10.4