Endometriosis
Infertility caused by an association between Arg72Pro polymorphism of the p53 gene and Glu298Asp of the eNOS gene in patients with endometriosis
Authors: T.R. Santos, K.S.F. e Silva, R.C.P.C. Silva, K.K.V.O. Moura, L.A. Guillo, C.L. Ribeiro J�ºnior and I.R. Costa
Endometriosis is characterized by ectopic endometrial tissue and affects millions of women worldwide. The disease leads to various symptoms such as chronic pelvic pain and infertility and does not yet have a well-defined etiology. The pathology is similar to cancer, since endometrial cells are highly proliferative, invade tiss.. Read More»
- Genet. Mol. Res. 17(3):
- http://dx.doi.org/gmr18046
- DOI:
- http://dx.doi.org/10.4238/gmr18046
Genetic Polymorphism in Endometriosis: Trends in Scientific Production
Authors: Maria Gabriela Machado Junqueira, Amanda Fernandes Costa, Felipe de Ara�ºjo Nascimento, K�¡tia Karina Verolli de Oliveira Moura, Fl�¡via Melo Rodrigues
Endometriosis is characterized by the presence of endometrial tissue located outside the uterine cavity. The prevalence is around 6 to 10%. Regarding etiopathogenesis, several theories are accepted, but alterations in the molecular biology of the endometrium seem to be fundamental for the development of endometriosis. Women wi.. Read More»
- Genet. Mol. Res. 17(1):
- gmr16039891
- DOI:
- 10.4238/gmr16039891
Association of TP53 gene codon 72 polymorphism with endometriosis in Mexican women
Authors: M.P. Gallegos-Arreola, L.E. Figuera-Villanueva, A.M. Puebla-P�©rez, H. Montoya-Fuentes, A.E. Suarez-Rincon and G.M. Z�º�±iga-Gonz�¡lez
The TP53 tumor suppressor gene plays an important role in cell cycle regulation; polymorphisms of this gene have been associated with endometriosis. We examined the role of TP53 codon 72 polymorphism by comparing genotypes of 235 healthy Mexican women (controls with surgically excluded endometriosis) with the genotypes of 151 .. Read More»
- Genet. Mol. Res. 11(2):
- 2012.May.15.10
- DOI:
- 10.4238/2012.May.15.10
Analysis of p53 codon 72 gene polymorphism in Brazilian patients with endometriosis
Authors: C.L. Ribeiro J�ºnior, J.T. Arruda, C.T.X. Silva andK.K.V.O. Moura
We examined the frequency of p53 codon 72 polymorphism in 38 patients with endometriosis whose diagnosis was confirmed using videolaparoscopy. Half of the women were infertile. There were no significant differences in the genotype (P = 0.0927) or allele frequencies (P = 0.1430) for p53 Arg72Pro polymorphism between the two gro.. Read More»
- Genet. Mol. Res. 8(2):
- vol8-2gmr593
- DOI:
- 10.4238/vol8-2gmr593
Effects of conservative laparoscopic endometrial cystectomy and use of kidney-reinforcing and blood activating traditional Chinese medicine on ovarian functions
Authors: Y.H. Huang, L. Shen, A.H. Cai and X.F. Liang
This study investigated functional changes in the ovaries of women who have had conservative laparoscopic endometrial cystectomy and the effects of traditional kidney-reinforcing and blood-activating Traditional Chinese Medicine (TCM) on ovarian function. Seventy female patients who underwent laparoscopic endometrial cystectomy were randomized into two group.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.6
- DOI:
- 10.4238/2015.January.30.6
DNA repair genes in endometriosis
Authors: R. Attar, C. Cacina, S. Sozen, E. Attar and B. Agachan
Several polymorphisms in the DNA repair gene are thought to have significant effects on cancer risk. We investigated the association of polymorphisms in the DNA repair genes XRCC1 Arg399Gln, XRCC3 Thr241Met, XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys with endometriosis risk. Genotypes were determined by.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr779
- DOI:
- 10.4238/vol9-2gmr779
Polymorphism of the progesterone receptor gene associated with endometriosis in patients from Goi�¡s, Brazil
Authors: I.R. Costa, R.C.P.C. Silva, A.B. Frare, C.T.X. Silva, B.M. Bordin, S.R. Souza, C.L. Ribeiro J�ºnior and K.K.V.O. Moura
We investigated a possible link between endometriosis and polymorphism of the progesterone receptor gene (PROGINS). The endometriosis group consisted of 54 patients with a diagnosis of endometriosis by laparoscopy, and the control group comprised 44 women without endometriosis. Genotypes for PROGINS polymorphisms (A1/A1, A1/A2.. Read More»
- Genet. Mol. Res. 10(3):
- vol10-3gmr913
- DOI:
- 10.4238/vol10-3gmr913
Association of CYP1A1 (cytochrome P450) MspI polymorphism in women with endometriosis
Authors: A.M. Barbosa, S.R. de Souza,, A.B. Frare, R.C. Costa e Silva, I.R. da Costa, K.S. Freitas e Silva, C.L. Ribeiro J�ºnior, B.M. Bordin and K.K.V.O. Moura
Endometriosis is a disease that affects 10 to 15% of the women of reproductive age. It is characterized by the presence of endometrial-like tissues outside of the uterus. Some definitions claim that the functional ectopic tissue is sensitive to the action of hormones. Severity of endometriosis is defined according to a system proposed by the American Soci.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15038389
- DOI:
- 10.4238/gmr.15038389
TP53 gene polymorphisms at codons 11, 72, and 248 and association with endometriosis in a Brazilian population
Authors: C.M. Camargo-Kosugi, P. D�Amora, J.P.F.O. Kleine, C.V. Carvalho, H. Sato, E. Schor and I.D.C.G. Silva
We evaluated the association between TP53 gene polymorphisms and endometriosis in Brazilian women. Genomic DNA was extracted from swabs of buccal cells collected from hospital patients. TP53 gene polymorphisms were investigated at three codons: TP53*11 Glu/Gln or Lys (GAG->CAG or AAG), TP53*.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.August.26.1
- DOI:
- 10.4238/2014.August.26.1
Association between CYP19A1, GSTM1, GSTT1, and GSTP1 genetic polymorphisms and the development of endometriosis in a Chinese population
Authors: Y. Tuo, J.Y. He, W.J. Yan and J. Yang
Endometriosis is a common, complicated, and highly heterogeneous endocrine disease. Many genetic factors could affect the development of endometriosis. We performed a case-control study to evaluate the association between polymorphisms in CYP19A1 rs2899470, GSTM1, GSTT1, and GSTP1 rs1695 and the development of endometriosis in.. Read More»
- Genet. Mol. Res. 15(4):
- gmr15048837
- DOI:
- 10.4238/gmr15048837