Chronic Obstructive Pulmonary Disease
The exploration of potential relationship between COPD and LUAD based on single-cell sequencing and bulk transcriptome sequencing
Authors: Yanjiao Zhang*, Yicheng Liang
Background: Lung Adenocarcinoma (LUAD) and Chronic Obstructive Pulmonary Disease (COPD) are lung diseases that may share some common etiological factors and mechanisms. Epithelial-Mesenchymal Transition (EMT) plays an essential role in regulating numerous physiological and pathological processes. This study aimed to evaluate potential rel.. Read More»
- Genet. Mol. Res. 24(1):
Association of the CYP1A1 MspI and TNF�±-308 polymorphisms with chronic obstructive pulmonary disease in Inner Mongolia
Authors: L. Yang, F. Li2*, M. Yan and X. Su
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by persistent airflow limitation. Smoking, occupational exposures, air pollution, and genetics are all risk factors. In the present study, we detected the cytochrome P4501A1 gene (CYP1A1) MspI polymorphism and the tumor necrosis factor alp.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.25.6
- DOI:
- 10.4238/2014.April.25.6
Association of -238G/A and -863C/A polymorphisms in the TNF-�± gene with chronic obstructive pulmonary disease based on a meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease; increasing evidence indicates that the TNF-α polymorphism is associated with progression of this disease. Few studies have focused upon association between TNF-α -238G/A or -863C/A polymorphism and COPD risk. Reported associations have been controversial b.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.24.10
- DOI:
- 10.4238/2013.October.24.10
Analysis of protein-protein interaction network in chronic obstructive pulmonary disease
Authors: Y.P. Yuan, Y.H. Shi and W.C. Gu
Chronic obstructive pulmonary disease (COPD) is a growing cause of morbidity and mortality throughout the world. The purpose of our study was to uncover biomarkers and explore its pathogenic mechanisms at the molecular level. The gene expression profiles of COPD samples and normal controls were downloaded from Gene Expression Omnibus. Matlab was used for .. Read More»
- Genet. Mol. Res. 13(4):
15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation
Authors: X.Y. Li1,2, B.L. Luo1, L.J. Wang1, W.D. Zhang2 and Z.G. Liu2
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates antioxidant and anti-inflammatory genes, and it plays a crucial role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Moreover, 15-deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) plays a protective role against oxidative stress and inflammation bot.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.29.22
- DOI:
- 10.4238/2015.October.29.22
Role of proteinase-activated receptor-1 gene polymorphisms in susceptibility to chronic obstructive pulmonary disease
Authors: C.M. Yun and X.Y. Sang
We conducted a case-control study to investigate the association between PAR1 gene polymorphisms and the development of chronic obstructive pulmonary disease (COPD). A total of 270 patients with COPD and 270 control subjects were consecutively recruited between March 2012 and March 2014. A polymerase chain reaction restriction fragment length polymorphism.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.October.26.18
- DOI:
- 10.4238/2015.October.26.18
Integrated statistical learning of metabolic ion mobility spectrometry profiles for pulmonary disease identification
Authors: A.-C. Hauschild J.I. Baumbach J. Baumbach
Exhaled air carries information on human health status. Ion mobility spectrometers combined with a multi-capillary column (MCC/IMS) is a well-known technology for detecting volatile organic compounds (VOCs) within human breath. This technique is relatively inexpensive, robust and easy to use in every day practice. However, the potential of this methodolog.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.17
- DOI:
- 10.4238/2012.July.10.17
Association of XRCC5 polymorphisms with COPD and COPD-related phenotypes in the Han Chinese population: a case-control cohort study
Authors: B. Wang, J. Yang, J. Xiao, B. Liang, H.X. Zhou, Z. Su, S. Xu, H. Chen, C. Ma, J. Deng, D. Li, H. Zhou, X. Ou and Y. Feng
Genome-wide association studies (GWAS) and integrative genomic approaches have demonstrated significant associations between chronic obstructive pulmonary disease (COPD) and polymorphisms of the X-ray repair cross-complementing protein 5 gene (XRCC5) in non-Asian populations. We investigated whether XRCC5 polymorphisms might b.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.January.24.11
- DOI:
- 10.4238/2014.January.24.11
Association of vitamin D-binding protein variants with chronic obstructive pulmonary disease: a meta-analysis
Authors: Y.L. Wang, H. Kong, W.P. Xie and H. Wang
Gene polymorphism of vitamin D-binding protein (VDBP) correlates with chronic obstructive pulmonary disease (COPD), but the results remain inconclusive. We aimed to explore the association between VDBP gene polymorphism and COPD. We searched MEDLINE, Embase, Web of Science, and China National Knowledge Infrastructure for publications addressing the associ.. Read More»
- Genet. Mol. Res. 14(3):
- http://dx.doi.org/2015.September.9.16
- DOI:
- http://dx.doi.org/10.4238/2015.September.9.16
Association of interleukin-1�² -511C/T promoter polymorphism with COPD risk: a meta-analysis
Authors: Y.S. Wang, L. Liu, X.Y. Xu, J.L. Wang, H. Zhou, T.L. Li and Z.A. Liang
Studies examining the role of interleukin (IL)-1β -511C/ T promoter polymorphism in the pathogenesis of chronic obstructive pulmonary disease (COPD) have shown inconsistent results. This metaanalysis was performed to assess the association between the IL-1β -511C/T promoter polymorphism and COPD susceptibility. Published case-control, cross-sect.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.5
- DOI:
- 10.4238/2015.May.4.5