Chronic Obstructive Pulmonary Disease
Association of the TNF-�± +489 G/A polymorphism with chronic obstructive pulmonary disease risk in Asians: meta-analysis
Authors: K. Cui, X.Y. Ge and H.L. Ma
The association between the TNF-α +489 G/A polymorphism and chronic obstructive pulmonary disease (COPD) remains controversial because of small group size and varied design among different studies. In the present study, a meta-analysis was conducted to assess the association between the +489 G/A polymorphism and COPD risk. A comprehensive search was.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.18.12
- DOI:
- 10.4238/2015.May.18.12
Correlation of spicule sign on computed tomography scans with peripheral lung cancers associated with interstitial lung disease and chronic obstructive pulmonary disease
Authors: L. Chen, L. Gao and W.L. Wu
The objective of this study was to investigate the correlation between spicular signs on computed tomography (CT) scans and peripheral lung cancer (PLC) that is associated with interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD). We analyzed clinical data from 96 PLC cases and grouped patients based on whether they had interst.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.March.27.9
- DOI:
- 10.4238/2015.March.27.9
Relationship between glutathione S-transferase P1 polymorphisms and chronic obstructive pulmonary disease in a Tunisian population
Authors: R. Lakhdar, S. Denden, J. Knani, N. Leban, H. Daimi, M. Hassine, G. Lefranc, J. Ben Chibani and A. Haj Khelil
Chronic obstructive pulmonary disease (COPD) is a multifactorial disease with possible genetic predisposition and involvement of various environmental factors. Several candidate genes have been reported as potentially associated with this lung disease. The glutathione S-transferase P1 gene (GSTP1) was proposed to be involved i.. Read More»
- Genet. Mol. Res. 9(2):
- vol9-2gmr770
- DOI:
- 10.4238/vol9-2gmr770
Upregulation of ICAM-1 and IL-1�² protein expression promotes lung injury in chronic obstructive pulmonary disease
Authors: Y.X. Wang, M.L. Ji, C.Y. Jiang and Z.B. Qian
Chronic obstructive pulmonary disease (COPD) is a devastating lung disorder characterized by sustained airway flow restriction that is not fully reversible. The precise pathogenic mechanisms are unknown, but it is clear that cigarette smoking and chronic inflammatory stimulation are the major causes of COPD. Lung inflammation associated with COPD involves.. Read More»
- Genet. Mol. Res. 15(3):
- gmr.15037971
- DOI:
- 10.4238/gmr.15037971
Dual role of vitamin D-binding protein 1F allele in chronic obstructive pulmonary disease susceptibility: a meta-analysis
Authors: M. Xiao, T. Wang, T. Zhu and F. Wen
Vitamin D-binding protein (DBP), a highly polymorphic serum protein, encoded by GC gene, is important in the development of chronic obstructive pulmonary disease (COPD). This meta-analysis was performed to assess the association between GC polymorphisms (1F, 1S, and 2 alleles) and COPD susceptibility. Published case-control studies were retrieved from the.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.17.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.17.1
Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis
Authors: X.M. Xie, R. Ke, Y.H. Zhang, G.Z. Wang, Y.T. Zhu, T. Hussian, L. Yang and M.X. Li
Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Kn.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.28.21
- DOI:
- 10.4238/2015.July.28.21
Exploration of association between EPHX1 and chronic obstructive pulmonary disease on the basis of combined data mining
Authors: L. An, H. Xia, P. Zhou and L. Hua
Chronic obstructive pulmonary disease (COPD) is an important respiratory disease with high mortality. Although smoking is the major environmental risk factor for the development of COPD, only 10% of heavy smokers develop symptomatic disease, suggesting association between genetic susceptibilities and environmental influences. .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028639
- DOI:
- 10.4238/gmr.15028639
Impact of adherence to GOLD guidelines on 6-minute walk distance, MRC dyspnea scale score, lung function decline, quality of life, and quality-adjusted life years in a Shanghai suburb
Authors: Y.Q. Jiang, Y.X. Zhu, X.L. Chen, X. Xu, F. Li, H.J. Fu, C.Y. Shen, Y.Y. Lu, Q.J. Zhuang, G. Xu, Y.Y. Cai, Y. Zhang, S.S. Liu, M.Y. Zhu and S.H. Li
We performed a 1-year cluster-randomized field trial to assess the effect of standardized management of chronic obstructivepulmonary disease (COPD) on lung function and quality of life (QOL) measures in patients in China. We used the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines and assessed indexes including pulmonary.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.9
- DOI:
- 10.4238/2015.August.3.9
The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease
Authors: S. Simsek, S. Tekes, D. Oral, A. Turkyilmaz, B. Isik, M.R. Isik and H. Akkoc
An insertion/deletion (I/D) polymorphism was identified in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoki.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.10
- DOI:
- 10.4238/2013.April.25.10
Associations between HIF-1�± polymorphisms C1772T and G1790A and susceptibility to chronic obstructive pulmonary disease
Authors: W.T. Wei, B. Li, M. Chen, H.R. Jia and H.X. Zhang
In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.2
- DOI:
- 10.4238/2015.December.21.2