Atherosclerosis
Polymorphisms of GSTM1 and GSTT1 genes in symptomatic atherosclerotic patients with hypertension and/or type 2 diabetes mellitus
Authors: R.S. Mascarenhas, F.R.B. Oliveira, J.F. Corr�?ªa, K.S.F. e Silva, I.R. Costa, A.M. Barbosa, M.H. Lagares, F.L. Campedelli, M.P. de Morais, J.V.M. Martins, D.A. Rodrigues, e K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory condition and originates due to the accumulation of lipids in the innermost layer of the arteries. It is often related due to other underlying diseases, such as systemic arterial hypertension and type 2 diabetes mellitus, which may be the cause or may contribute to a worse prognosis of.. Read More»
- Genet. Mol. Res. 16(4):
- gmr16039836
- DOI:
- 10.4238/gmr16039836
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis
Authors: M.H. Lagares, K.S.F. Silva, A.M. Barbosa, D.A. Rodrigues, I.R. Costa, J.V.M. Martins, M.P. Morais, F.L. Campedelli and K.K.V.O. Moura
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subseq.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039721
- DOI:
- 10.4238/gmr16039721
Molecular analysis of the GSTT1 gene polymorphism in patients with clinical manifestation of atherosclerosis
Authors: J.V.M. Martins, D.A. Rodrigues, K.S.F. Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. Morais and K.K.V.O. Moura
Atherosclerosis is a chronic inflammatory disease formed by the accumulation of lipids in the innermost layer and large-caliber artery (tunica intima). This accumulation, along with platelet factors, stimulates the proliferation of muscle cells in this region. Over than 400 genes may be related to the pathology since they regu.. Read More»
- Genet. Mol. Res. 16(3):
- gmr16039620
- DOI:
- 10.4238/gmr16039620
Homocysteine induces blood vessel global hypomethylation mediated by LOX-1
Authors: X.L. Yang, J. Tian, Y. Liang, C.J. Ma, A.N. Yang, J. Wang, S.C. Ma, Y. Cheng, X. Hua and Y.D. Jiang
Homocysteine (Hcy) is an independent risk factor of atherosclerosis through its involvement with the methionine cycle. In this study, we aimed to determine the blood vessel global methylation rate in Hcy-induced atherosclerosis in apolipoprotein-E-deficient (ApoE-/-) mice, and to explore the possible mechanism of this change i.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.16.2
- DOI:
- http://dx.doi.org/10.4238/2014.May.16.2
Effects of atorvastatin in combination with ezetimibe on carotid atherosclerosis in elderly patients with hypercholesterolemia
Authors: P. Luo, L. Li, L.X. Wang, H.H. Zhu, S. Du, S.L. Wu, Y.G. Han and G.G. Wang
The aim of this study was to observe the effects of atorvastatin combined with ezetimibe on carotid atherosclerosis in elderly patients with hypercholesterolemia. A total of 84 elderly hypercholesterolemic patients complicated with carotid atherosclerosis were divided into control group (atorvastatin alone) and combined group .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.3.10
- DOI:
- 10.4238/2014.April.3.10
GSTM1 polymorphism in patients with clinical manifestations of atherosclerosis
Authors: D.A. Rodrigues, J.V.M. Martins, K.S.F. e Silva, I.R. Costa, M.H. Lagares, F.L. Campedelli, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura
Atherosclerosis is characterized by lesions, called atheroma or atheromatous plaques, in the inner layer of blood vessels, which block the vascular lumen and weaken the underlying tunica media. Several modifiable and non-modifiable risk factors for the development of atherosclerosis exist. The modifiable risk factors include h.. Read More»
- Genet. Mol. Res. 16(1):
- gmr16019101
- DOI:
- 10.4238/gmr16019101
Role of mitochondrial DNA variants and copy number in diabetic atherogenesis
Authors: M.C. Chien W.T. Huang P.W. Wang C.W. Liou T.K. Lin C.J. Hsieh S.W. Weng
Hyperglycemia-induced reactive oxygen species production can cause diabetes and its complications, including atherosclerosis. The role of mitochondrial DNA variants and mitochondrial copy number in the pathogenesis of diabetic atherogenesis is not well understood. We examined 36 diabetic patients who had undergone amputation for diabetic foot and seven non-d.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.September.17.4
- DOI:
- 10.4238/2012.September.17.4
Interleukin-4 regulates macrophage polarization via the MAPK signaling pathway to protect against atherosclerosis
Authors: X.N. Zhao1, Y.N. Li2 and Y.T. Wang1
Our study aimed to investigate the effects of interleukin-4 (IL-4) on macrophage polarization, as well as its role in the development of atherosclerosis. Human peripheral blood mononuclear cells (PBMCs) were isolated and randomly divided into 3 groups: control group, ox-LDL group, and ox-LDL + IL-4 groups. The expression of M1/M2 macrophage surface marker.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017348
- DOI:
- 10.4238/gmr.15017348
Polymorphism of the gene eNOS G894T (Glu298Asp) in symptomatic patients with aterosclerosis
Authors: F.L. Campedelli, K.S.F. e Silva, D.A. Rodrigues, J.V.M. Martins, I.R. Costa, M.H. Lagares, A.M. Barbosa, M.P. de Morais and K.K.V.O. Moura
Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alteratio.. Read More»
- Genet. Mol. Res. 16(2):
- gmr16029550
- DOI:
- 10.4238/gmr16029550
Role of fibroblast growth factor-23 in the pathogenesis of atherosclerosis in peritoneal dialysis patients
Authors: Y. Zeng, S. Feng, O.Y. Han, H.Y. Shen, D.H. Jin and Y.B. Shi
Several previous studies have demonstrated that elevated levels of fibroblast growth factor-23 (FGF-23) may be involved in atherosclerosis and contribute to the high mortality rate of peritoneal dialysis (PD) patients. The aim of this study was to determine the precise role of FGF-23 in the pathogenesis of atherosclerosis in PD patients. Between April 200.. Read More»
- Genet. Mol. Res. 14(1):
- 2015.January.30.15
- DOI:
- 10.4238/2015.January.30.15