Atherosclerosis
Expression of high-mobility group box protein 1 in diabetic foot atherogenesis
Authors: C.F. Tsao, W.T. Huang, T.T. Liu, P.W. Wang, C.W. Liou, T.K. Lin,C.J. Hsieh and S.W. Weng
The role of high mobility group box 1 (HMGB1) has been demonstrated in stroke and coronary artery disease but not in peripheral arterial occlusive disease (PAOD). The pathogenesis of HMGB1 in acute and chronic vascular injury is also not well understood. We hypothesized that HMGB1 induces inflammatory markers in diabetic PAOD patients. We studied 36 diabe.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.10
- DOI:
- 10.4238/2015.May.4.10
Correlation between polymorphism of platelet alloantigen genes HPA-1-5 and type 2 diabetes complication by carotid atherosclerosis in a Chinese population
Authors: Y.H. Zhang, S.F. Xu, J. Zheng, H.S. Hong and L.M. Fan
We investigated the association between the polymorphism of human platelet alloantigen genes HPA-1-HPA-5 and the complication of type 2 diabetes mellitus (T2DM) by carotid atherosclerosis (CA) among Han people in Guiyang District, China. Ninety-nine T2DM patients were selected from the Affiliated Hospital of Guiyang Medical College and divided into a CA(+.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.May.4.19
- DOI:
- 10.4238/2015.May.4.19
Effect of GBOT on blood lipid and blood glucose metabolism in rats with atherosclerosis
Authors: A. Rong, G. Borjihan and Y.J. Qiao
We observed the variation in in vivo blood lipid and blood glucose metabolism in rats with atherosclerosis after 5-(3,4-dihydroxy-phenyl)-1-piperidin-1-yl-penta-2,4-dien-1-one (GBOT) administration. Wistar rats aged 10 weeks received a high-fat diet to establish the atherosclerosis model. Metabolic indices related to blood lipid and blood glucose were mea.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.July.14.6
- DOI:
- 10.4238/2015.July.14.6
Association among oxidized LDL levels, MnSOD, apolipoprotein E polymorphisms, and cardiovascular risk factors in a south Brazilian region population
Authors: Maria G.V. Gottlieb, Carla H.A. Schwanke, Adriana F.R. Santos, Paulo F. Jobim, Denise P. M�¼ssel and Ivana B.M. da Cruz
Oxidized LDL (ox-LDL) is involved in the initiation and progression of atherosclerosis. Many factors can affect the LDL oxidation such as oxidative stress. The present study tested whether ox-LDL levels would be associated with apolipoprotein E (APOE), manganese superoxide dismutase (MnSOD) Ala16Val polymorphisms, and classic .. Read More»
- Genet. Mol. Res. 4(4):
Effect of Xin Mai Jia on atherosclerosis in rats
Authors: P. Li, G.P. Pan, M. Jia, Q.Q. Wang, Z.G. Guo, F.R. Zhao, G.L. Lei, G.R. Wan and G.M. Wan
We investigated the therapeutic effect of Xin Mai Jia (XMJ) on atherosclerosis (AS) in rats. Rat models of AS were established by peritoneally injecting vitamin D, feeding a high-fat diet, and inducing balloon injuries in rats. The stomachs of the rats were irrigated continuously for 10 weeks with XMJ. Blood lipid- and hemorheologyrelated indices of blood.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.1.19
- DOI:
- 10.4238/2015.June.1.19
Prediction of genetic risk factors of atherosclerosis using various bioinformatic tools
Authors: H.X. Wang and Y.X. Zhao
The aim of this study was to identify potential markers of atherosclerosis development in familial hypercholesterolemia (FH) patients. GSE13985 microarray data, generated using blood samples from 5 FH patients and 5 matched controls, was downloaded from the Gene Expression Omnibus. Differentially expressed genes (DEGs) between.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027347
- DOI:
- 10.4238/gmr.15027347
Protective effect of the polarity of macrophages regulated by IL-37 on atherosclerosis
Authors: J. Huang, F.L. Hou, A.Y. Zhang and Z.L. Li
As an anti-inflammatory cytokine, interleukin-37 (IL-37) provides certain protective effects against inflammatory and autoimmune diseases. Recent reports indicate that IL-37 is expressed in foam cells of atherosclerotic plaques in both the coronary and carotid arteries of humans, suggesting the possible involvement of IL-37 in.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027616
- DOI:
- 10.4238/gmr.15027616
Decreased levels of soluble receptor for advanced glycation end-products in aortic valve calcification patients
Authors: H. Zheng,Y. Li,N. Xie,J.L. Huang,H.F. Xu and M. Luo
The soluble receptor for advanced glycation end-products (sRAGE) shows a close relationship with atherosclerosis. The goal of this study was to compare the levels of sRAGE in patients with and without aortic valve calcification and to investigate the relationship between them. After transthoracic echocardiographic examination, 120 male patients with aorti.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.6
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.6