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Animal Genetics   Research Article

Uncoupling Proteins and Cardiac Apoptosis in High Fat Diet-Fed Male Rats

Authors: K. Alsolami, Z. Alrefaie

This study aimed to assess impact of high fat diet (HFD) on cardiac apoptosis, and cardiac uncoupling proteins (UCPs) 2&3 expression. Twenty rats were fed either (45%) or (10%) fat diet for 6 months, then cardiac tissue expression of BAX, Bcl2, Fas, Fas-L (markers for apoptotic pathways) and UCP 2&3 were assessed. Results revealed enhancement of i.. Read More»

Genet. Mol. Res. 19(1):
Animal Genetics   Research Article

Protective effect of Vitamin D on Cardiac Mitochondrial Apoptotic pathway in Rats fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zienab Alrefaie, Hossam Awad

Background: Both diet quality and vitamin D status are important factors associated with many cardiovascular risk factors. Cardiac mitochondrial pathway of apoptosis has been associated with those factors. The current work aimed to assess the effect of chronic consumption of high fat diet (HFD) on the cardiac markers of mitochondrial path.. Read More»

Genet. Mol. Res. 19(5):
Animal Genetics   Research Article

Potential Protective Effect of Vitamin D on Cardiac Extrinsic pathways of apoptosis in Male Rats Fed with high fat diet

Authors: Khadeejah Mesaid Al-Solami, Zainab Al-refaie, Hossam Awad, Mahmood Rasool

Background: Obesity and vitamin D deficiency are increasing in Kingdom of Saudi Arabia (KSA) in last decades. Researchers have shown a relation between both disorders and cardiovascular disease (CVD). The present work aimed to investigate the possible protective effect of vitamin D on cardiac apoptosis in rats fed with a high fat diet. Methods: This study.. Read More»

Genet. Mol. Res. 18(1):
Human Genetics   Research Article

The Disruption of Klf6-Related Super-Enhancer Induces Growth Inhibition and Apoptosis in Human HepG2 Cells

Authors: KumChol Ri, KumChol Kim, SunHyok Kong, JuHua Ri

Klf6 is a member of the Krüppel-like factor family, which is a group of zinc finger transcription factors involved in differentiation and development. In general, Klf6 gene plays an important role in growth-related signal transduction pathways, cell proliferation, apoptosis, and angiogenesis. Recently, the Klf6 gene is co.. Read More»

Genet. Mol. Res. 17(1):
gmr16039888
DOI:
10.4238/gmr16039888
Human Genetics   Research Article

Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism.

Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz

This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»

Genet. Mol. Res. 16(4):
gmr16039818
DOI:
10.4238/gmr16039818
Human Genetics   Research Article

Promotion of apoptosis in high glucose-activated hepatic stellate cells by GLP-1 receptor agonist and its potential mechanism

Authors: Lingkang Wu, Yingchao Liu, Liangliang Shi, Bingbing Zhang, Ana Carolina Picolo Pasian and Andrei Moroz

This study aimed to investigate the stimulatory effect of glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1RA) on the apoptosis of hepatic stellate cells (HSCs) activated by high glucose, and to explore the underlying molecular mechanism with a focus on the c-Jun N-terminal kinase (JNK) and extracellular signal-related k.. Read More»

Genet. Mol. Res. 16(4):
gmr16039818
DOI:
10.4238/gmr16039818
Human Genetics   Research Article

miR-1 association with cell proliferation inhibition and apoptosis in vestibular schwannoma by targeting VEGFA

Authors: S.L. Li, X.H. Ma, J.F. Ji, H. Li, W. Liu, F.Z. Lu, S.T. Wu and Y. Zhang

A growing body of research has demonstrated the tumor suppressive function of microRNA (miR)-1 in many cancers. Our study aimed to investigate its role in vestibular schwannoma (VS). We examined miR-1 expression in 95 VS specimens and 79 normal vestibular nerves using quantitative real-time polymerase chain reaction. Moreover,.. Read More»

Genet. Mol. Res. 15(4):
gmr15048923
DOI:
10.4238/gmr15048923
Human Genetics   Research Article

Clinical significance and expression of PUMA, MCL-1, and p53 in human renal cell carcinoma and para-carcinoma tissues

Authors: H.B. Xia, H.W. Cui, L. Su, Z.H. Zhang, X.Y. Yang, S.Q. Ning and X.L. Su

We investigated the expression level of p53 upregulated modulator of apoptosis (PUMA), myeloid cell leukemia-I (MCL-1), and p53 in renal cell carcinoma (RCC) and para-carcinoma tissues, as well as their clinical significance. The expression levels of PUMA, MCL-1, and p53 in RCC and para-carcinoma tissues were measured using im.. Read More»

Genet. Mol. Res. 16(3):
gmr16039278
DOI:
10.4238/gmr16039278
Animal Genetics   Research Article

Low-frequency ultrasound induces apoptosis of rat aortic smooth muscle cells (A7r5) via the intrinsic apoptotic pathway

Authors: B. Zhang, H.S. Zhou, Q. Cheng, L. Lei and B. Hu

Ultrasound, a non-invasive therapy method, is a potential tool for medical applications, but its biological effects on vascular smooth muscle cells (VSMCs) have not been characterized. The aim of this study was to explore the effect and possible apoptotic mechanism of VSMCs that were induced by low-frequency ultrasound (LFU). .. Read More»

Genet. Mol. Res. 13(2):
2014.April.17.10
DOI:
10.4238/2014.April.17.10
Human Genetics   Research Article

Apoptotic effects of proteasome and histone deacetylase inhibitors in prostate cancer cell lines

Authors: I. Kiliccioglu, E. Konac, N. Varol, S. Gurocak and C. Yucel Bilen

Prostate cancer is one of the most common types of urological cancers. Despite the implementation of effective radiotherapy and chemotherapy methods, prostate cancer cells can still show resistance to treatment. In recent years, a combination of proteasome and histone deacetylase inhibitors has been used to treat various malig.. Read More»

Genet. Mol. Res. 13(2):
http://dx.doi.org/2014.May.9.17
DOI:
http://dx.doi.org/10.4238/2014.May.9.17

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