Microarray-based gene expression profiles in rabbit retina due to negative pressure suction
Authors: H.X. Zhao, C.M. Niu and W.Y. Guan
We investigated a possible molecular pathogenesis involving retinal ganglion cell apoptosis following transient high intraocular pressure. Changes in the gene expression profiles of the retina were detected via gene chip methodology. Twelve New Zealand white rabbits were randomly assigned to control and 3-min negative pressure suction groups. The control .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.9
- DOI:
- 10.4238/2012.May.18.9
Novel nonsense and frameshift NTRK1 gene mutations in Chinese patients with congenital insensitivity to pain with anhidrosis
Authors: M. Li, J.Y. Liang, Z.H. Sun, H. Zhang and Z.R. Yao
Congenital insensitivity to pain with anhidrosis (CIPA; MIM 256800) is a rare autosomal recessive disorder characterized by absence of reaction to noxious stimuli, recurrent episodes of fever, anhidrosis, and mental retardation. It is caused by mutations in the gene coding for neurotrophic tyrosine kinase receptor type 1 (NTRK1; MIM# 191315). We screened .. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.18.8
- DOI:
- 10.4238/2012.May.18.8
Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico
Authors: E. Flores-Alfaro, G. FernÃ?¡ndez-Tilapa, E. Salazar-MartÃ?Ânez, M. Cruz, B. Illades-Aguiar and I. Parra-Rojas
Variants in the C-reactive protein (CRP) gene have been found to be associated with various phenotypic traits. We evaluated the effect of four SNPs in the CRP gene on serum levels of protein and body mass index (BMI) in 150 unrelated Mexican subjects from 18 to 25 years old, without hypertension, non-overweight, and without inflammatory diseases, non-smok.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.14.5
- DOI:
- 10.4238/2012.May.14.5
Screening and prevention of neonatal glucose 6-phosphate dehydrogenase deficiency in Guangzhou, China
Authors: J. Jiang, B. Li, W. Cao, X. Jiang, X. Jia, Q. Chen and J. Wu
We aimed to summarize the results of screening protocol and prevention of neonatal glucose 6-phosphate dehydrogenase (G6PD) deficiency during a 22-year-long period to provide a basis of reference for the screening of this disease. About 1,705,569 newborn subjects in Guangzhou City were screened for this deficiency. Specimens w.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.13
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.13
Differences in numbers of termicins expressed in two termite species affected by fungal contamination of their environments
Authors: P. Xu, M. Shi, R. Lai and X.-X. Chen
Termicin is a defensin-like antimicrobial peptide of termites that has strong antifungal activity. Fifty-six different termicin mRNAs encoding 46 different peptides were amplified and identified from Odontotermes formosanus (Termitidae), a species that inhabits environments with a large variety of microbial fauna. In contrast, only 38 different termicin m.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.10.2
- DOI:
- 10.4238/2012.May.10.2
Single nucleotide polymorphism screening, molecular characterization, and evolutionary aspects of chicken Piwi genes
Authors: H.Z. Wang, T. Ma, G.B. Chang, F. Wan, X.P. Liu, L. Lu, L. Xu, J. Chen and G.H. Chen
The P-element-induced wimpy testis (Piwi) gene is involved in germline stem cell self-renewal, meiosis, RNA silencing, and transcriptional regulation. Piwi genes are relatively well conserved in many species, but their function in poultry species is unclear. In this study, Piwi genes were sequenced u.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.45
- DOI:
- 10.4238/2015.November.18.45
Intra-aortic balloon pump treatment for patients with acute anterior wall myocardial infarction after reperfusion therapy
Authors: C.G. Feng, X.J. Yang, Q. Fu, Y.J. Wang, H.Y. Ruan, Y. Lu, X.L. Li and X.P. Zhang
We evaluated the effects of an intra-aortic balloon pump on hemodynamics, brain natriuretic peptide concentration and cardiac function of patients with acute myocardial infarction, after reperfusion therapy. Sixty-three patients with acute anterior wall ST-elevation myocardial infarction who underwent primary percutaneous coro.. Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.14
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.14
High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis
Authors: G.Q. Zeng, A.B. Chen, W. Li, J.H. Song and C.Y. Gao
Our study examined the relationship between the expression of matrix metalloproteinases (MMP)-1, MMP-2, and MMP-9 proteins and the pathogenesis of osteoarthritis (OA). We employed rigorous inclusion and exclusion criteria in computer-based bibliographic databases to extract published studies relevant to this investigation. The.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.46
- DOI:
- 10.4238/2015.November.18.46
Protein families, natural history and biotechnological aspects of spider silk
Authors: D. Bittencourt, P.F. Oliveira, F. Prosdocimi and E.L. Rech
Spiders are exceptionally diverse and abundant organisms in terrestrial ecosystems and their evolutionary success is certainly related to their capacity to produce different types of silks during their life cycle, making a specialized use on each of them. Presenting particularly tandemly arranged amino acid repeats, silk proteins (spidroins) have mechanic.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.August.13.10
- DOI:
- 10.4238/2012.August.13.10
Meta-analysis of the relationship between XRCC3 T241M polymorphism and colorectal cancer susceptibility
Authors: L.Z. Zhang, Y.S. Li and H.Z. Liu
Numerous studies have evaluated the relationship between the T241M polymorphism of the X-ray repair cross-complementing group 3 (XRCC3) gene and colorectal cancer (CRC) risk. However, the specific relationship remains controversial. We conducted meta-analysis to investigate the relationship between the XRCC3 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.48
- DOI:
- 10.4238/2015.November.18.48