Association of MMP7-181A/G and MMP13-77A/G polymorphisms with colorectal cancer in a Mexican population
Authors: J.M. Moreno-Ortiz, M. GutiÃ?©rrez-Angulo, M. Partida-PÃ?©rez, J. Peregrina-Sandoval, R. RamÃ?Ârez-RamÃ?Ârez, R. MuÃ?±iz- endoza, S. SuÃ?¡rez-Villanueva, M. Centeno-Flores, V. Maciel-GutiÃ?©rrez, J.E. Cabrales-Vazquez and M.L. Ayala-Madrigal
Colorectal cancer (CRC) is characterized by enhanced expression and activity of several metalloproteinases (MMPs), including MMP13 and MMP7, which play an important role in tumor invasion and metastasis. The objective of this study was to analyze the association of functional MMP7-181A/G and MMP13-77A/G promoter polymorphisms .. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.1
- DOI:
- 10.4238/2014.February.14.1
Identification of hybrids between triticale and Aegilops juvenalis (Thell.) Eig and determination of genetic similarity with ISSRs
Authors: A. Gradzielewska, D. Gruszecka, J. LeÃ?Â?niowska-Nowak and E. Paczos-GrzÃ?Â?da
Wide hybridization expands the gene pool of cultivated species and can produce genotypes with practical value, often resistant to diseases. In plants, ISSRs are often used for hybrid identification as well as for diversity evaluation. We estimated genetic similarity among advanced genetic stocks of triticale hybrids and identified Aegilops juvenalis intro.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.July.10.1
- DOI:
- 10.4238/2012.July.10.1
Effect of different carbon sources on proteases secreted by the fungal pathogen Sclerotinia sclerotiorum during Phaseolus vulgaris infection
Authors: E.A. Bueno, M.B. Oliveira, R.V. Andrade, M. Lobo Junior and S. Petrofeza
Sclerotinia sclerotiorum (Sclerotiniaceae) is a plant pathogenic fungus that causes white mold disease in vegetable crops, including the common bean (Phaseolus vulgaris). Proteases produced by fungi are normally an important part of the pathogenic process in the host. We examined the effect of different carbon sources - pectin, glucose, and cell wall of P.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.25.3
- DOI:
- 10.4238/2012.June.25.3
Association of the g.27563G>A osteoprotegerin genetic polymorphism with bone mineral density in Chinese women
Authors: Y.P. Liu, D.W. Zhao, W.M. Wang, B.J. Wang, Y. Zhang and Z.G. Li
Osteoporosis is a common multifactorial disease in postmenopausal women. This study aimed to investigate the association of the g.27563G>A osteoprotegerin (OPG) genetic polymorphism with bone mineral density (BMD) and osteoporosis. A case-control study was carried out with 435 osteoporosis postmenopausal women cases and 442.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.February.14.9
- DOI:
- 10.4238/2014.February.14.9
Transcriptomic profiles of Japanese medaka (Oryzias latipes) in response to alkalinity stress
Authors: Z.L. Yao, H. Wang, L. Chen, K. Zhou, C.Q. Ying and Q.F. Lai
Oryzias latipes (Adrianichthyidae), known as Japanese medaka or Japanese killifish, is a small 2-4 cm long fish common in rice paddies in coastal Southeast Asia and is also a popular aquarium fish. It has been widely used as a research model because of its small size and because it is very easy to rear. Alkalinity stress is considered to be one of the maj.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.June.15.2
- DOI:
- 10.4238/2012.June.15.2
Selection of peptides for serological detection of equine infectious anemia
Authors: E.M. Santos, R. Cardoso, G.R.L. Souza, L.R. Goulart, M.B. Heinemann, R.C. Leite and J.K.P. Reis
Equine infectious anemia caused by equine infectious anemia virus is an important disease due to its high severity and incidence in animals. We used a phage display library to isolate peptides that can be considered potential markers for equine infectious anemia diagnosis. We selected peptides using IgG purified from a pool comprised of 20 sera from anima.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.24.2
- DOI:
- 10.4238/2012.May.24.2
Meta analysis of angiotensin-converting enzyme I/D polymorphism as a risk factor for preeclampsia in Chinese women
Authors: W.G. Zhong, Y. Wang, H. Zhu and X. Zhao
Preeclampsia affects 3-8% of pregnancies and is a major cause of maternal and perinatal morbidity and mortality worldwide. Inappropriate activation of the renin-angiotensin system may play a role in the development of preeclampsia. An insertion/deletion polymorphism in the angiotensin-converting enzyme gene (ACE-I/D) has been associated with differences i.. Read More»
- Genet. Mol. Res. 11(3):
- 2012.May.21.1
- DOI:
- 10.4238/2012.May.21.1
Separation and identification of Musa acuminate Colla (banana) leaf proteins by two-dimensional gel electrophoresis and mass spectrometry
Authors: Y. Lu, Y.X. Qi, H. Zhang, H.Q. Zhang, J.J. Pu and Y.X. Xie
To establish a proteomic reference map of Musa acuminate Colla (banana) leaf, we separated and identified leaf proteins using two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) and mass spectrometry (MS). Tryptic digests of 44 spots were subjected to peptide mass fingerprinting (PMF) by matrix-assisted laser desorption/ionization time-of-flight .. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.19.6
- DOI:
- 10.4238/2013.December.19.6
KDR gene silencing inhibits proliferation of A549cells and enhancestheir sensitivity to docetaxel
Authors: R. Wei and J.-P. Zang
We investigated the effects of kinase-domain insert containing receptor (KDR) gene silencing on the proliferation of A549 cells and their sensitivity to docetaxel. After designing and synthesizing the KDR siRNA sequence, the sequence was transfected into A549 cells using Lipofectamine 2000. The expression of KDR.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.November.18.43
- DOI:
- 10.4238/2015.November.18.43
Accuracy of low-field MRI on meniscal tears
Authors: H.N. Chen, Q.R. Dong and Y. Wang
This study aimed to verify the accuracy of low-field-intensity magnetic resonance imaging (MRI) in diagnosing meniscus tears. A total of 171 patients were examined through low-field-intensity MRI to detect meniscus injuries. These patients were then diagnosed through arthroscopy. Examination results were recorded and compared... Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.June.9.12
- DOI:
- http://dx.doi.org/10.4238/2014.June.9.12