Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people
Authors: Y.H. Liu, Y.W. Zhou, J.A.Yang, Z.G. Tu, S.Y. Ji, Z.Y. Huang and Z.J. Zhou
This study investigated 5 single nucleotide polymorphism (SNP) haplotypes in susceptibility genes for coronary artery disease (CAD) and the putative involvement of these SNPs in CAD in the Chinese Han population. From March 2008 to June 2009, we selected 119 CAD patients and 115 subjects not related to the CAD of Chinese Han o.. Read More»
- Genet. Mol. Res. 13(2):
- 2014.April.8.4
- DOI:
- 10.4238/2014.April.8.4
Regulation network analysis of testicular seminoma at various stages of progression
Authors: J.-J. Sha, Y.-H. Dong, D.-M. Liu, J.-J. Bo, Y.-R. Huang, Z. Li and P. Ping
Testicular seminoma has become the most common solid malignancy in young men, especially in the 20s group. We obtained the gene expression profile of human testicular seminoma cells from NCBI, identified the differentially expressed genes of testicular seminoma cells of different stages, and constructed the regulation networks of different stages of testi.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.March.11.11
- DOI:
- 10.4238/2013.March.11.11
Effect of erythropoietin on mesenchymal stem cell differentiation and secretion in vitro in an acute kidney injury microenvironment
Authors: N.M. Liu, J. Tian, W.W. Wang, G.F. Han, J. Cheng, J. Huang and J.Y. Zhang
We investigated the effect of erythropoietin (EPO) on differentiation and secretion of bone marrow-derived mesenchymal stem cells in an acute kidney injury microenvironment. Acute kidney injury mouse models were prepared. Both renal cortices were then immediately collected to produce the ischemia/reperfusion kidney homogenate supernatant. The morphologica.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.14
- DOI:
- 10.4238/2013.February.28.14
Maternal MTHFR C677T polymorphism and congenital heart defect risk in the Chinese Han population: a meta-analysis
Authors: K.H. Chen, L.L. Chen, W.G. Li, Y. Fang and G.Y. Huang
Numerous studies have evaluated the association between the maternal C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and congenital heart defect (CHD) risk in the Chinese Han population. However, the specific association is still controversial. Six separate studies with 1089 subjects in the Chinese Han population on the relation.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.December.4.8
- DOI:
- 10.4238/2013.December.4.8
Use of morpho-agronomic traits and DNA profiling for classification of genetic diversity in papaya
Authors: O.N. de Jesus, J.P.X. de Freitas, J.L.L. Dantas and E.J. de Oliveira
We examined the genetic diversity of papaya (Carica papaya) based on morpho-agronomic and molecular data. Twenty-seven genotypes grown in Brazil were analyzed with 11 AFLP primer combinations, 23 ISSR markers, 22 qualitative, and 30 quantitative descriptors. For the joint analyses, we used the Gower algorithm (Joint Gower) and the average value of the ind.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.July.11.8
- DOI:
- 10.4238/2013.July.11.8
Polymorphisms of vascular endothelial growth factor on prognosis in hepatocellular carcinoma patients receiving transcatheter arterial chemoembolization treatment
Authors: J. Song, L.Z. Wang, X. Li, T.P. Jiang, T.Z. An, M. Xu, X.P. Wu and S. Zhou
We conducted a cohort study to investigate the prognostic significance of vascular endothelial growth factor (VEGF) polymorphisms in hepatocellular carcinoma (HCC) patients after transcatheter arterial chemoembolization (TACE). In total, 156 patients with histologically confirmed HCC within 2 months were collected from January 2007 to January 2008. The ge.. Read More»
- Genet. Mol. Res. 13(4):
Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat
Authors: X.P. An, P. Han, J.X. Hou, H.B. Zhao, Y. Yan, T. Ma, F. Fang, F.X. Meng, Y.X. Song, J.G. Wang and B.Y. Cao
Kisspeptins, the product of the KISS1 gene, play an essential role in the regulation of reproductive functions, acting primarily at the hypothalamic level of the gonadotropic axis. We detected polymorphisms of the goat KISS1 gene in 723 individuals from three goat breeds (Xinong Saanen, Guanzhong, and Boer) by DNA pooling, PCR-RFLP, and DNA sequencing met.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.February.28.13
- DOI:
- 10.4238/2013.February.28.13
Quantitative genetic study of age at subsequent rebreeding in Nellore cattle by using survival analysis
Authors: M.H. Van Melis, L.G.G. Figueiredo, H.N. Oliveira, J.P. Eler,G.J.M. Rosa, M.L. Santana Jr., F.M. Rezende and J.B.S. Ferraz
The continuous trait age at subsequent rebreeding (ASR) was evaluated using survival analysis in Nellore breed cows that conceived for the first time at approximately 14 months of age. This methodology was chosen because the restricted breeding season produces censored data. The dataset contained 2885 records of ASR (in days)... Read More»
- Genet. Mol. Res. 13(2):
- http://dx.doi.org/2014.May.30.2
- DOI:
- http://dx.doi.org/10.4238/2014.May.30.2
Changes of Th1/Th2 cytokines in immunocompetent patients with pulmonary cryptococcosis
Authors: J.L. Wang, S.Y. Li, Y.F. Luo, Y.P. Zhai and X.Q. Wei
The aim of this study was to investigate the changes of Th1/Th2 cytokines in immunocompetent patients with pulmonary cryptococcosis (PC). Twenty immunocompetent patients with PC were identified by histopathological examination and were enrolled in the study along with the age- and gender-matched healthy controls. The serum concentrations of interferon-g (.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.November.18.22
- DOI:
- 10.4238/2013.November.18.22
Culture-independent analysis of endophytic bacterial communities associated with Brazilian sugarcane
Authors: G.S. Magnani1, L.M. Cruz1, H. Weber2, J.C. Bespalhok2, E. Daros2, V. Baura1, M.G. Yates1, R.A. Monteiro1, H. Faoro1, F.O. Pedrosa1 and E.M. Souza1
Sugarcane is an economically important culture in Brazil. Endophytic bacteria live inside plants, and can provide many benefits to the plant host. We analyzed the bacterial diversity of sugarcane cultivar RB-72454 by cultivation-independent techniques. Total DNA from sugarcane stems from a commercial plantation located in Paraná State was extracted.. Read More»
- Genet. Mol. Res. 12(4):
- 2013.October.15.3
- DOI:
- 10.4238/2013.October.15.3