Role of ACE and AGT gene polymorphisms in genetic susceptibility to diabetes mellitus type 2 in a Brazilian sample
Authors: L.M. Wollinger, S.M. Dal Bosco, C. Rempel, S.E.M. Almeida, D.B. Berlese, R.P. Castoldi, M.E. Arndt, V. Contini and J.P. Genro
The aim of the current study was to investigate the association between the InDel polymorphism in the angiotensin I-converting enzyme gene (ACE) and the rs699 polymorphism in the angiotensinogen gene (AGT) and diabetes mellitus type 2 (DM2) in a sample population from Southern Brazil. A case-control study was conducted with 228 patients with DM2 and 183 c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.20
- DOI:
- 10.4238/2015.December.29.20
Combination of edaravone and neural stem cell transplantation repairs injured spinal cord in rats
Authors: Y.Y. Song, C.G. Peng and X.B. Ye
This study sought to observe the effect of the combination of edaravone and neural stem cell (NSC) transplantation on the repair of complete spinal cord transection in rats. Eighty adult female Sprague-Dawley (SD) rats were used to establish the injury model of complete spinal cord transection at T9. Animals were divided randomly into four groups (N = 20 .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.23
- DOI:
- 10.4238/2015.December.29.23
A wavelet-based feature vector model for DNA clustering
Authors: J.P. Bao and R.Y. Yuan
DNA data are important in the bioinformatic domain. To extract useful information from the enormous collection of DNA sequences, DNA clustering is often adopted to efficiently deal with DNA data. The alignment-free method is a very popular way of creating feature vectors from DNA sequences, which are then used to compare DNA similarities. This paper propo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.26
- DOI:
- 10.4238/2015.December.29.26
Association between MTHFR gene polymorphisms (C677T, A1298C) and genetic susceptibility to prostate cancer: a meta-analysis
Authors: P.L. Chen, W.T. Li, J. Wang, Y.D. Jiang, P. Wu, T. Chen and S.B. Zheng
Genetic polymorphisms (C677T and A1298C) in methylenetetrahydrofolate reductase (MTHFR) were shown to be related to prostate cancer risk in previous studies; however, the results are controversial. We performed a meta-analysis of previous studies and quantitatively estimated these associations. Pubmed, Embase, and Cochrane Library Database were searched f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.29
- DOI:
- 10.4238/2015.December.29.29
Meta-analysis of association between IL-6 -634C/G polymorphism and osteoporosis
Authors: L. Yan, R. Hu, S. Tu, W.J. Cheng, Q. Zheng, J.W. Wang, W.S. Kan and Y.J. Ren
Osteoporosis is a common disease in the aging population and studies have shown that interleukin-6 (IL-6) is potentially implicated in its pathogenesis. This study was designed to assess the association between the IL-6 gene -634C/G polymorphism and osteoporosis. PubMed, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.32
- DOI:
- 10.4238/2015.December.29.32
Transcriptome analysis of the grass carp (Ctenopharyngodon idella) using 454 pyrosequencing methodology for gene and marker discovery
Authors: L.Y. Yu, J.J. Bai, J.J. Fan, D.M. Ma, Y.C. Quan and P. Jiang
Total RNA isolated from the brain, muscle, liver, gonad, and intestinal tissues of grass carp was pooled to construct cDNA libraries. Using 454 pyrosequencing, a total of 738,604 high-quality reads were generated from the normalized cDNAs of the pooled individuals. Clustering and assembly of these reads produced a set of 37,086 all-unigene sequences after.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.35
- DOI:
- 10.4238/2015.December.29.35
Repeatability of agronomic traits in Panicum maximum (Jacq.) hybrids
Authors: T.G.S. Braz, D.M. Fonseca, L. Jank, C.D. Cruz and J.A. Martuscello
When evaluating plants, in particular perennial species, it is common to obtain repeated measures of a given trait from the same individual to evaluate the traits’ repeatability in successive harvests. The degree of correlation among these measures defines the coefficient of repeatability, which has been widely utilized in the study of forage traits.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.38
- DOI:
- 10.4238/2015.December.29.38
Isolation and characterization of polymorphic EST-SSR and genomic SSR markers in spotted mandarin fish (Siniperca scherzeri Steindachne)
Authors: Y.Q. Dou, X.F. Liang, M. Yang, C.X. Tian, S. He and W.J. Guo
Spotted mandarin fish (Siniperca scherzeri Steindachne) feed solely on live fry of other fish species once the fry start feeding in the wild. In the present study, 26 polymorphic transcriptome-derived simple sequence repeat (SSR) markers and 14 genomic SSR markers were developed and characterized in S. scherzeri Steindachne by combining a biotin-enrichmen.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.41
- DOI:
- 10.4238/2015.December.29.41
Correlation between matrix metalloproteinase-9 and vascular endothelial growth factor expression in lung adenocarcinoma
Authors: Y.L. Wen and L. Li
The aim of this study was to investigate the correlation between the expression of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) and clinicopathological features of lung adenocarcinoma. The expression of MMP-9 and VEGF was evaluated by immunohistochemistry of 30 samples from lung adenocarcinoma patients and 12 paratumora.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.44
- DOI:
- 10.4238/2015.December.29.44
Association between the AGTR1 A1166C polymorphism and risk of IgA nephropathy: a meta-analysis
Authors: J.M. Xu, X. Song, F. Gao and R. Wang
Numerous studies have evaluated the association between the A1166C polymorphism in the angiotensin II type 1 receptor (AGTR1) gene and immunoglobulin A nephropathy (IgAN) risk. However, this relationship remains controversial. Our aim was to evaluate the relationship between this polymorphism and IgAN susceptibility by performing a meta-analysis. Articles.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.47
- DOI:
- 10.4238/2015.December.29.47