PPAR�³ Pro12Ala and His447His polymorphisms and susceptibility to Alzheimerâ��s disease: a meta-analysis
Authors: Y.H. Lee and G.G. Song
We investigated whether Pro12Ala (C→G) and His447His (C→T) polymorphisms of the peroxisome proliferatoractivated receptor gamma (PPARg) gene are associated with susceptibility to Alzheimer’s disease (AD). We conducted a metaanalysis of the associations between the PPARg Pro12Ala and His447His polymorphisms and AD in subjects. The meta-anal.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.18
- DOI:
- 10.4238/2015.June.29.18
Association of phosphodiesterase 4D gene and interleukin-6 receptor gene polymorphisms with ischemic stroke in a Chinese hypertensive population
Authors: H.J. Song, X.H. Zhou, L. Guo, F.L. Tian, X.F. Guo and Y.X. Sun
Genetic factors have been shown to be associated with the risk of stroke. However, due to individual differences, the extent of the association between genetic factors and stroke varies widely. Hypertension is considered one of the most important risk factors for stroke, but it remains unknown whether the genetic association with stroke in a hypertensive .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.50
- DOI:
- 10.4238/2015.December.29.50
Malondialdehyde and SOD-induced changes of gastric tissues in acute gastric mucosal injury under positive acceleration
Authors: J. Li, H.L. Tang, Y. Chen, Q. Fan, Y.T. Shao, M. Jia, J.C. Wang and C.M. Yang
The aim of this study was to investigate the impacts of positive acceleration (+Gz) on the gastric mucosal tissues in cases of acute gastric mucosal injury and to explore the role of oxygen free radicals. Thirty Sprague Dawley rats were randomly divided into the absolute ethanol control group (A group), absolute et.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.9
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.9
Ion beam transformation with corn DNA alters proteinase expression in rice seedling roots
Authors: W.C. Li, S.D. Ji, X.C. Wang, Z.K. Li, H.C. Zhang, C.Z. Tian,Y.L. Liuand C.X. Duan
Corn DNA was introduced into dry seeds of rice (cv. ‘YuJing-6’) by ion beam irradiation. Proteinase activities in rice seedling roots were subsequently analyzed by renaturation electrophoresis at pH 4.5, 7.0, and 8.5. Proteinase activity was more pronounced on gels at higher pH. Irradiation of r.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.19
- DOI:
- 10.4238/2015.June.29.19
Public sphere and the sustainability of the bioinformatics promise
Authors: Marcelo Leite
The literature about genomics and bioinformatics achievements in high-impact journals such as Nature and Science has raised disproportionate expectations amongst the general public about fast and revolutionary drugs and breakthroughs in biomedicine. However, the yield obtained by database mining activities has been modest, as .. Read More»
- Genet. Mol. Res. 3(4):
Bioinformatics: perspectives for the future
Authors: Luciano da Fontoura Costa
I give here a very personal perspective of Bioinformatics and its future, starting by discussing the origin of the term (and area) of bioinformatics and proceeding by trying to foresee the development of related issues, including pattern recognition/data mining, the need to reintegrate biology, the potential of complex network.. Read More»
- Genet. Mol. Res. 3(4):
Using bradykinin-potentiating peptide structures to develop new anti hypertensive drugs
Authors: Jorge Hernandez Fernandez, Goran Neshich and Antonio Carlos M. Camargo
Angiotensin I-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase expressed in endothelial, epithelial and neuroepithelial cells. It is composed of two domains, known as N- and C-domains, and it is primarily involved in blood pressure regulation. Although the physiological functions of ACE are not limited to its cardiovas.. Read More»
- Genet. Mol. Res. 3(4):
The olfactory receptor universe - from whole genome analysis to structure and evolution
Authors: Tsviya Olender, Ester Feldmesser, Tal Atarot, Miriam Eisenstein and Doron Lancet
Olfactory receptors (ORs) constitute the largest gene-family in the vertebrate genome. We have attempted to provide a comprehensive view of the OR universe through diverse tools of bioinformatics and computational biology. Among others, we have constructed the Human Olfactory Receptor Data Exploratorium (HORDE, http://bioporta.. Read More»
- Genet. Mol. Res. 3(4):
A bioinformatics analysis of alternative exon usage in human genes coding for extracellular matrix proteins
Authors: Noboru Jo Sakabe, Maria Dulcetti Vibranovski and Sandro Jos�© de Souza
Alternative splicing increases protein diversity through the generation of different mRNA molecules from the same gene. Although alternative splicing seems to be a widespread phenomenon in the human transcriptome, it is possible that different subgroups of genes present different patterns, related to their biological roles. An.. Read More»
- Genet. Mol. Res. 3(4):
A novel human G protein-coupled receptor is over-expressed in prostate cancer
Authors: Raphael B. Parmigiani, Geraldo S. Magalh�£es, Pedro A.F. Galante,Carina V.B. Manzini, Anamaria A. Camargo and Bettina Malnic
G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the i.. Read More»
- Genet. Mol. Res. 3(4):