Characterization and functional analysis of a chitin synthase gene (HcCS1) identified from the freshwater pearlmussel Hyriopsis cumingii
Authors: H.F. Zheng, Z.Y. Bai, J.Y. Lin, G.L. Wang, J.L. Li
The triangle sail mussel, Hyriopsis cumingii, is the most important freshwater pearl mussel in China. However, the mechanisms underlying its chitin-mediated shell and nacre formation remain largely unknown. Here, we characterized a chitin synthase (CS) gene (HcCS1) in H. cumingii, and analyzed its possible physiological function. The complete ORF sequence.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.36
- DOI:
- 10.4238/2015.December.29.36
ApoE and S-100 expression and its significance in the brain tissue of rats with focal contusion
Authors: Z.L. Wang, R.F. Chai, W.S. Yang, Y. Liu, H. Qin, H. Wu, X.F. Zhu, Y.X. Wang and G. Dangmurenjiafu
This study explored the effect of focal cerebral contusion on the expression of ApoE and S-100, and its significance in determining the time of brain injury. Based on a rat model of cerebral contusion, immunohistochemistry was used to analyze the expressions of S-100 and ApoE at different time points after injury. Thirty minutes following cerebral contusi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.37
- DOI:
- 10.4238/2015.December.29.37
Salmonella enterica Typhimurium fljBA operon stability: implications regarding the origin of Salmonella enterica I 4,[5],12:i:-
Authors: M.P.O. Tomiyama, C.H. Werle, G.P. Milanez, D.B. N�³brega, J.P. Pereira, A.P. Calarga, F. Flores and M. Brocchi
Salmonella enterica subsp enterica serovar 4,5,12:i:- has been responsible for many recent Salmonella outbreaks worldwide. Several studies indicate that this serovar originated from S. enterica subsp enterica serovar Typhimurium, by the loss of the flagellar phase II gene (fljB) and adjacent sequences. However, at least two different clones of S. enterica.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.13
- DOI:
- 10.4238/2015.December.29.13
Association of SNPs in the PPAR�³ gene and hypertension in a Mongolian population
Authors: L. Yang, R.G. Tian, P.Y. Chang, M.R. Yan and X.L. Su
The association of single nucleotide polymorphisms (SNPs) in PPARγ with hypertension is controversial. The aim of the present study was to clarify the contributions of PPARγ genetic variants to hypertension through an association study. A total of 414 unrelated Mongolian herdsmen and 524 Han farmers were included in this study. Fourteen intron.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.39
- DOI:
- 10.4238/2015.December.29.39
MicroRNA screening and functional study of obliterative bronchiolitis in a rat model simulating lung transplantation
Authors: J. Wang, H. Cao, X. Hong, G.H. Chen, H.M. Fan, Q.C. Li, Z.M. Liu and K.F. Li
The aim of this study was to provide the experimental basis for effective prevention and treatment of obliterative bronchiolitis (OB) by studying the changes on the microRNA (miRNA) expression profile after an orthotopic tracheal transplantation (OTT) simulating lung transplantation (LT). The OTT was performed on inbred rats to establish an OB animal mode.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.40
- DOI:
- 10.4238/2015.December.29.40
Glucocorticoid receptor gene (NR3C1) promoter is hypermethylated in Thai females with major depressive disorder
Authors: M. Nantharat, T. Wanitchanon, M. Amesbutr, R. Tammachote and V. Praphanphoj
Major depressive disorder (MDD) has been associated with the stress response in the brain, which is controlled by the hypothalamic-pituitary-adrenal (HPA) axis. This HPA negative feedback mechanism acts via the activation of glucocorticoid receptor, which is encoded by the NR3C1 gene. The methylation status at the promoter of NR3C1 has been correlated wit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.15
- DOI:
- 10.4238/2015.December.29.15
Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia
Authors: Q.Y. Liu, F.Y. Gao, X.R. Liu, J. Li, M. Ji, J. Dong and X.T. Wang
In this case-control study, we assessed the influence of IL-10 -1082A/G and -819T/C on the development of preeclampsia. The IL-10 -1082A/G and -819T/C polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism. The genotype distributions of the IL-10 -1082A/G and -819T/C polymorphisms in the control subjects were in .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.42
- DOI:
- 10.4238/2015.December.29.42
Association between the 8q24 rs6983267 T/G polymorphism and prostate cancer risk: a meta-analysis
Authors: H.S. Zhu, J.F. Zhang, J.D. Zhou, M.J. Zhang and H.X. Hu
Recent studies have indicated that single nucleotide polymorphisms (SNPs) within the 8q24 region may be a risk factor for prostate cancer (PCa). Here, we performed a meta-analysis to evaluate the association between the 8q24 rs6983267 T/G polymorphism and PCa risk. A systematic literature search was carried out in multiple electronic databases independent.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.43
- DOI:
- 10.4238/2015.December.29.43
Two novel ATP2C1 mutations in patients with Hailey-Hailey disease and a literature review of sequence variants reported in the Chinese population
Authors: L. Meng, Y. Gu, X.F. Du, M.H. Shao, L.L. Zhang, G.L. Zhang and X.L. Wang
Hailey-Hailey disease (HHD) is an autosomal dominant disorder in which the ATP2C1 gene has been implicated. Many mutations of this gene have been detected in HHD patients. To analyze such mutations in HHD and summarize all those identified in Chinese patients with this disease, we examined four familial and two sporadic cases and searched for case reports.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.45
- DOI:
- 10.4238/2015.December.29.45
Linker length affects expression and bioactivity of the onconase fusion protein in Pichia pastoris
Authors: G.G. Yang, X.Y. Xu, Y. Ding, Q.Q. Cui, Z. Wang, Q.Y. Zhang, S.H. Shi, Z.Y. Lv, X.Y. Wang, J.H. Zhang, R.G. Zhang and C.S. Xu
The aim of this study was to analyze the effect of linker length on the expression and biological activity of recombinant protein onconase (ONC) in fusion with human serum albumin (HSA) in Pichia pastoris. Four flexible linkers with different lengths namely Linker L0, L1: (GGGGS)1, L2: (GGGGS)2, and L3:(GGGGS)3 were inserted into the fusion gene and refer.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.46
- DOI:
- 10.4238/2015.December.29.46