ORMDL3 variants associated with bronchiolitis susceptibility in a Chinese population
Authors: X.T. Liu, L. Ren, L.L. Zhou, Q.Y. Xiao, Y. Deng and E.M. Liu
Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibil.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.25
- DOI:
- 10.4238/2015.December.29.25
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer
Authors: J.P. Kleine, C.M. Camargo-Kosugi, C.V. Carvalho, F.C. Silva and I.D.C.G. Silva
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.3
- DOI:
- 10.4238/2015.December.29.3
Ultrasonic imaging of gunshot wounds in pig limb
Authors: Q. Li, D. Deng, J. Tao, X. Wu, F. Yi, G. Wang and F. Yang
We investigated wound tract extension of traumatic gunshot wounds in limb soft tissues as well as wound tract sonographic features and change-patterns when the limb position was changed. The experimental animals included 8 healthy crossbred pigs in the Chengdu plain region. Chinese Type 53 Carbine was used to establish the gunshot wound model of porcine s.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.1
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.1
Functional characterization and analysis of the Arabidopsis UGT71C5 promoter region
Authors: Z. Liu, Q.H. Luo, J.M. Wang, X.F. Li and Y. Yang
In the present study, we isolated an Arabidopsis promoter, UGT71C5, and analyzed its role in the regulation of the light response mechanism. We constructed a fusion vector pBI121-pU-GUS by integrating the UGT71C5 promoter upstream of the GUS reporter gene in pBI121, and then transferred this vector into Arabidopsis plants. The GUS activity of the transgen.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.27
- DOI:
- 10.4238/2015.December.29.27
Distribution of forensic marker allelic frequencies in Pernambuco, Northestern Brazil
Authors: S.M. Santos, C.A. Souza2, K.C.N. Rabelo, P.R.E. Souza,R.R. Moura, T.C. Oliveira, and S. Crovella
Pernambuco is one of the 27 federal units of Brazil, ranking seventh in the number of inhabitants. We examined the allele frequencies of 13 short tandem repeat loci (CFS1PO, D3S1358, D5S818, D7S820, D8S1179, D13S317, D16S539, D18S51, D21S11, FGA, TH01, vWA, and TPOX), the minimum recommended by the Federal Bureau of Investigation and commonly used in fore.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.2
Association of TNF-�± G308A gene polymorphism in essential hypertensive patients without type 2 diabetes mellitus
Authors: N. Ghodsian, M. Akhlaghi, V. Ramachandran, F. Heidari, P. Haghvirdizadeh, S.A. Eshkoor, A. Etemad, J.A. Jamaluddin and P. Ismail
This study aims to investigate the effects of tumor necrosis factor alpha (TNF-α) G308A gene polymorphism on essential hypertension (EHT) with or without type 2 diabetes mellitus (T2DM). The project was conducted on buccal epithelial and blood cells for case and control patients, respectively. Epithelial cells were obtained from the inner part of th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.4
- DOI:
- 10.4238/2015.December.29.4
Streptococcus massiliensis in the human mouth: a phylogenetic approach for the inference of bacterial habitats
Authors: F. P�³ntigo, C. Silva, M. Moraga and S.V. Flores
Streptococcus is a diverse bacterial lineage. Species of this genus occupy a myriad of environments inside humans and other animals. Despite the elucidation of several of these habitats, many remain to be identified. Here, we explore a methodological approach to reveal unknown bacterial environments. Specifically, we inferred the phylogeny of the Mitis gr.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.28
- DOI:
- 10.4238/2015.December.29.28
Association of CD14 C159T polymorphism with atopic asthma susceptibility in children from Southeastern China: a case-control study
Authors: Y.N. Zhang, Y.J. Li, H. Li, H. Zhou and X.J. Shao
CD14 is involved in primary immune and inflammatory responses. The -159 C/T variation in the CD14 gene plays an important role in regulating CD14 expression and has been associated with the susceptibility to various diseases, including allergies. In this study, we examined the association between the C-159T polymorphism and atopic asthma susceptibility in.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.3
Molecular cloning and expression analysis of female sterile homeotic gene (fsh) in the oriental river prawn Macrobrachium nipponense
Authors: W.Y. Zhang, S.F. Jiang, Y.W. Xiong, H.T. Fu1,, H. Qiao, S.M. Sun, Y.S. Gong and S.B. Jin
The gene female sterile homeotic (fsh) plays crucial roles in molecular function, including protein kinase activity and DNA binding, which are involved in biological processes such as terminal region determination and negative regulation of DNA-dependent transcription. Although fsh has been found in Drosophila melanogaster, little is known regarding its e.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.4
Deciphering the spectrum of somatic mutations in the entire mitochondrial DNA genome
Authors: X.Z. Chen, Y. Fang, Y.H. Shi, J.H. Cui, L.Y. Li, Y.C. Xu and B. Ling
The mitochondrion is a crucial intracellular organelle responsible for regulating cellular energy metabolism, producing free radicals, initiating and executing the apoptotic pathways. Previous studies have shown that somatic mutations in mitochondrial DNA are associated with various tumors, which may be involved during carcinogenesis and tumor progression.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.30.5
- DOI:
- http://dx.doi.org/10.4238/2015.April.30.5