Serum soluble RAGE level inversely correlates with left ventricular hypertrophy in essential hypertension patients
Authors: Q. Liu, H.B. Chen, M. Luo, H. Zheng
Soluble receptor for advanced glycation end-products (sRAGE) acts as a decoy to prevent interaction between RAGE and its pro-inflammatory ligands. sRAGE levels have been found to decrease in chronic inflammatory diseases, including hypertension. However, few data have been reported concerning the association between serum sRAG.. Read More»
- Genet. Mol. Res. 15(2):
Constructing gene network based on biclusters of expression data
Authors: F. Liu, L. Yang, Z.Z. Tian, P. Wu and S.L. Sun
Two genes can be co-regulated and possibly have the similar function if they are similarly expressed, which provides a theoretical basis for construction of gene regulatory networks using gene expression data. Herein, a new method of gene regulatory network was constructed based on biclusters in this paper. Given a bicluster, .. Read More»
- Genet. Mol. Res. 15(2):
Correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer among the Kazakh ethnic group in Xinjiang
Authors: M. Zeng, Y. Lv, H.F. Wang, H.A. Yiguli, J.R. Zhang and A. Yisikandaer
This study aimed to investigate the correlation of CYP1A1 and GSTM1 gene polymorphisms and environmental factors to familial aggregation of esophageal cancer (EC) among the Kazakh ethnic group in Xinjiang. CYP1A1 and GSTM1 gene polymorphisms were detected using peripheral blood from 86 subjects belonging to families with EC and 82 control subjects. Additi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.19
- DOI:
- 10.4238/2015.December.29.19
Genetic parameters for test day somatic cell score in Brazilian Holstein cattle
Authors: C.N. Costa, G.G. Santos, J.A. Cobuci, G. Thompson and J.G.V. Carvalheira
Selection for lower somatic cell count has been included in the breeding objectives of several countries in order to increase resistance to mastitis. Genetic parameters of somatic cell scores (SCS) were estimated from the first lactation test day records of Brazilian Holstein cows using random-regression models with Legendre polynomials (LP) of the order .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.21
- DOI:
- 10.4238/2015.December.29.21
Interleukin-10 polymorphisms and nasopharyngeal carcinoma risk: a meta-analysis
Authors: Y.-F. Yu, Z.-G. Han, W.-B. Guo, G.-J. Zhang, J.-K. Yang, F.-L. Wu, Q.-Y. Ou, Y.-H. Li, X.-Y. Cai, Z.-N. Zhan, J.-H. Chen, W.-L. Xie, L. Tang and C.-D. Liu
It has been reported that interleukin-10 (IL-10) promoter genes (1082 A/G, 819 T/C, 592 A/C) are associated with nasopharyngeal carcinoma (NPC). However, the results remain controversial and ambiguous. To resolve inconsistencies in published data, we performed a meta-analysis to ascertain the association between IL-10 polymorphisms and NPC risk. Two case-.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.1
- DOI:
- 10.4238/2015.December.29.1
Microsatellite DNA markers and their correlation with growth traits in mandarin fish (Siniperca chuatsi)
Authors: L.F. Sun, J. Li, X.F. Liang, T.L. Yi, L. Fang, J. Sun, Y.H. He, X.N. Luo, Y.Q. Dou and M. Yang
The mandarin fish (Siniperca chuatsi) is a traditionally cultured freshwater fish with high commercial value in China. To facilitate marker-assisted selection in genetic improvement of this species, 120 microsatellite markers from the literature were characterized in the 25 largest and 25 smallest individuals. Eighteen polymorphic loci were then used to g.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.22
- DOI:
- 10.4238/2015.December.29.22
Correlation between p53 and epidermal growth factor receptor expression in breast cancer classification
Authors: X.Z. Wang, Q. Liu, J.J. Sun, W.S. Zuo, D.W. Hu, S.G. Ma, D.B. Mu and Z.Y. Yu
This study aimed to explore new opportunities for developing targeted therapy for triple-negative breast cancer (TNBC) by analyzing the significance and association between p53 and epidermal growth factor receptor (EGFR) expression in different molecular subtypes of breast cancer. The clinical and pathological data of 264 patients with breast cancer recei.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.28.10
- DOI:
- http://dx.doi.org/10.4238/2015.April.28.10
Potential role of heat-shock proteins in giant cell tumors
Authors: J.T. Chen, A. Younusi, L. Cao, Z. Tian, Y.J. Zhou and X.H. Song
We investigated the differential expression protein profile of giant cell tumors (GCTs), which can be used to monitor the tumor’s recurrence and metastasis, to provide preliminary results for further study. We also explored heat-shock protein (HSP) inhibitor that prevents tumors from recurring and migrating. A stable isotope-labeling strategy using .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.24
- DOI:
- 10.4238/2015.December.29.24
ORMDL3 variants associated with bronchiolitis susceptibility in a Chinese population
Authors: X.T. Liu, L. Ren, L.L. Zhou, Q.Y. Xiao, Y. Deng and E.M. Liu
Recent studies revealed common genetic risks for both viral bronchiolitis and asthma. Genome-wide association studies revealed that rs7216389 in the ORMDL3 gene is associated with childhood asthma. We conducted a case-control study examining the associations between ORMDL3 polymorphisms (rs7216389, rs12603332, and rs11650680) and bronchiolitis susceptibil.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.25
- DOI:
- 10.4238/2015.December.29.25
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer
Authors: J.P. Kleine, C.M. Camargo-Kosugi, C.V. Carvalho, F.C. Silva and I.D.C.G. Silva
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer. Genotypes of 222 women were an.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.3
- DOI:
- 10.4238/2015.December.29.3