A comprehensive review of microRNA-related polymorphisms in gastric cancer
Authors: B.W. Han Z.H. Li, S.F. Liu, H.B. Han, S.J. Dong, H.J. Zou,R.F. Sun and J. Jia
MicroRNAs (miRNAs) are a class of small non-coding RNA molecules of about 22 nucleotides in length. miRNAs are highly conserved in both plants and animals, and function as gene regulators by binding to the 3'-untranslated region of target mRNAs for cleavage and/or translational repression. miRNA biogenesis, stability, and regu.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028289
- DOI:
- 10.4238/gmr.15028289
Hemoglobin (Hb) Val de Marne (Hb Footscray) in Brazil: the first case report
Authors: J.V. Okumura, E.L.T. Shimauti, D.G.H. Silva, L.S. Torres,E. Belini-Junior, R.G. Oliveira, E.V. Patussi, J.C.M. Herrero and C.R. Bonini-Domingos
Hemoglobin (Hb) variants involving alpha-chains are less common in the global population than Hb variants resulting from beta-chain alterations. Generally, alpha-chain Hb variants are caused by point mutations affecting alpha-1 and/or alpha-2 genes of the alpha-globin cluster (HBA1 and HBA2). In Brazil, the most prevalent alph.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028294
- DOI:
- 10.4238/gmr.15028294
Quercetin ameliorates LPS-induced inflammation in human peripheral blood mononuclear cells by inhibition of the TLR2-NF-�ºB pathway
Authors: M. Zhang, J.M. Lin, X.S. Li, J. Li
Quercetin, a dietary flavonoid abundant in fruits, vegetables, and herbs, presents various pharmacological effects. This study aimed to investigate the anti-inflammatory effect and the underlying mechanism of quercetin in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs). Cell viability was m.. Read More»
- Genet. Mol. Res. 15(2):
Enhanced salt tolerance in tomato plants constitutively expressing heat-shock protein in the endoplasmic reticulum
Authors: C. Fu, X.X. Liu, W.W. Yang, C.M. Zhao and J. Liu
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR) signaling pathway. The UPR signaling pathway is associated with plant responses to adverse environmental conditions. Thus, changes in the UPR signaling pathway might affect pla.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028301
- DOI:
- 10.4238/gmr.15028301
Novel polymorphism in exon 1 of the melatonin receptor gene unassociated with reproductive characteristics of buffaloes in the Amazon Region
Authors: E.M. Barbosa, B.B. Souza, R.C. Guimar�£es, J.S.N. Azevedo,E.C. Gon�§alves, H.F.L. Ribeiro, S.T. Rolim Filho and E. Silva Filho
The objective of this study was to sequence part of the exon 1 in the melatonin receptor 1A gene (MTRN1A) in buffaloes to detect a novel polymorphism with which to associate reproductive characteristics, such as age at first birth and the interval between births, in buffaloes from the northeastern region of the State of Par&aa.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028309
- DOI:
- 10.4238/gmr.15028309
Exome sequencing in Thai patients with familial obesity
Authors: S. Kaewsutthi, J. Santiprabhob, B. Phonrat, A. Tungtrongchitr,P. Lertrit and R. Tungtrongchitr
Obesity is a major worldwide health issue, with increasing prevalence in adults and children from developed and developing countries. Obesity causes several chronic diseases, including cardiovascular and respiratory diseases, osteoarthritis, hypertension, stroke, type II diabetes, obstructive sleep apnea, and several types of .. Read More»
- Genet. Mol. Res. 15(2):
Prevalence of human papillomavirus (HPV), distribution of HPV types, and risk factors for infection in HPV-positive women
Authors: M.V.C. Santos Filho, A.P.A.D. Gurgel, C.D.P. Lobo, A.C.F. Freitas, J.C. Silva-Neto and L.A.F. Silva
The aim of this study was to describe the prevalence of human papillomavirus (HPV), the distribution of different HPV types, and the putative risk factors for infection among HPV-positive women from the State of Alagoas, Northeast Brazil. We analyzed data from 515 patients attending public and private health centers. HPV DNA f.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028315
- DOI:
- 10.4238/gmr.15028315
Comparative sequence and expression analysis of tapetum specific male sterility related genes in Medicago truncatula
Authors: L.H. Shao, X.W. Zheng, D.X. Yi and C. Li
Heterosis, or enhancement through outbreeding, is one of the most promising approaches for increasing crop yield. Male sterility (MS), which promotes heterosis, has been widely applied in hybrid crop production. Medicago truncatula is a model legume species and is closely related to M. sativa, an important legume forage plant... Read More»
- Genet. Mol. Res. 15(2):
Association between monoamine oxidase B A644G polymorphism and Parkinson�s disease risk: a meta-analysis in the Chinese population
Authors: J.J. Liu, W. Wang, M. Meng, C.S. Liang and J.W. Zhang
Although various individual studies have evaluated the correlation between monoamine oxidase B (MAOB), polymorphism, and Parkinson’s disease (PD), the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between the MAOB polymorphi.. Read More»
- Genet. Mol. Res. 15(2):
Association between atopic dermatitis-related single nucleotide polymorphisms rs4722404 and psoriasis vulgaris in a southern Chinese cohort
Authors: G. Shi, C.M. Cheng, T.T. Wang, S.J. Li, Y.M. Fan and K.J. Zhu
Genome-wide association studies have identified a single nucleotide polymorphism (SNP), rs4722404, in the caspase recruitment domain family member 11 (CARD11) gene, which is associated with atopic dermatitis. Previous genetic studies have also reported genomic similarities between psoriasis and atopic dermatitis. However, little is known regarding the ass.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028356
- DOI:
- 10.4238/gmr.15028356