Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance
Authors: X. Yu, Y. Li, S.W. Chen, Y. Shi and F. Xu
In this study, we examined the expression of glypican-3 (GPC3) in the 2 most common histological types of lung cancer, squamous cell carcinoma and adenocarcinoma, and explored the relationship between GPC3 expression and the prognosis of these 2 types of lung cancers. Lung cancer tissues and paracancerous tissues were collected from a total of 60 patients.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.2
- DOI:
- 10.4238/2015.August.28.2
Correlation between polymorphisms in the visfatin gene and its expression in the serum and coronary artery calcification
Authors: L.W. Jin, S.B. Zheng, Z.H. Zhou, S.F. Pan and Y. Zheng
We investigated the association between serum visfatin levels and single nucleotide polymorphisms (SNPs; rs61330082, rs2058539) in the visfatin gene and coronary artery calcification (CAC) in patients from Wenzhou, China. CAC patients (N = 206) were divided into two groups: mild CAC (MCAC) and moderate and severe CAC (MSCAC). .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028217
- DOI:
- 10.4238/gmr.15028217
Association of genetic variations in the ACLY gene with growth traits in Chinese beef cattle
Authors: M.N. Li, X. Guo, P.J. Bao, X.Y. Wu, X.Z. Ding, M. Chu, C.N. Liang and P. Yan
ATP citrate lyase (ACLY) is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA, which is a key precursor of both fatty acid and mevalonate synthesis pathways. Genetic variation of the ACLY gene may influence multiple traits associated with animal production. Here, we identified three non-synonymous mutati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028250
- DOI:
- 10.4238/gmr.15028250
Meta-analysis of IL-6 -174G/C polymorphism and psoriasis risk
Authors: G. Nie, C.L. Xie, Y.J. Cao, M.M. Xu, X. Shi, A.L. Zou and J.H. Qi
Previous studies examining the association between interleukin-6 (IL-6) -174G/C polymorphism and psoriasis risk have produced inconsistent results. The aim of this study was to offer a comprehensive review of the association between IL-6 -174G/C polymorphism and psoriasis risk through a meta-analysis. Literature search of PubM.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028255
- DOI:
- 10.4238/gmr.15028255
Notification of Huntington�s disease as primary cause of death in Brazil from 1984 to 2008
Authors: I.P. Vaz and C.L.A. Paiva
The aim of this article was to conduct a retrospective observational study on reported deaths due to Huntington’s disease (HD) in Brazil in the past 25 years (from 1984 to 2008). Data were obtained from the Brazilian Mortality Information System (SIM/DATASUS), the official system of Brazilian Mortality Database. The data.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028257
- DOI:
- 10.4238/gmr.15028257
Splicing mutation of a gene within the Duchenne muscular dystrophy family
Authors: Y.B. Zhu, J.H. Gan, J.W. Luo, X.Y. Zheng, S.C. Wei and D. Hu
The aim of this study was to identify the mutation site and phenotype of the Duchenne muscular dystrophy (DMD) gene in a DMD family. The DMD gene is by far the largest known gene in humans. Up to 34% of the point mutations reported to date affect splice sites of the DMD gene. However, no hotspot mutation has been reported. Cap.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028258
- DOI:
- 10.4238/gmr.15028258
Complete mitochondrial genome of the Liuyang black goat and its phylogenetic relationship with other Caprinae
Authors: S. Chen, H.M. Ma, G.S. Chen and L.Y. Wang
In this study, the complete mitochondrial genome sequence of the Liuyang black goat was investigated, and phylogenetic relationships between the Liuyang black goat and other species of Caprinae were analyzed. The total length of the mitochondrial genome was 16,715 bp, which consisted of 33.50% A, 27.27% T, 25.98% C, and 13.25%.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028267
- DOI:
- 10.4238/gmr.15028267
Genetic effect of an A/G polymorphism in the HSP70 gene on thermotolerance in chicken
Authors: Z.Y. Chen, W.W. Zhang, J.K. Gan, L.N. Kong, X.Q. Zhang,D.X. Zhang and Q.B. Luo
Studying thermotolerance is important for the prevention of thermostress in chickens. This study aimed to analyze the effect of mutations in the heat shock protein 70 (HSP70) gene on chicken thermotolerance. The C.-69A>G SNP in the 5'-flanking region of the HSP70 gene was genotyped in Lingshan and White Recessive Rock (WRR).. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028271
- DOI:
- 10.4238/gmr.15028271
Correlation between hepatitis B virus DNA levels and diagnostic tests for HBsAg, HBeAg, and PreS1-Ag in chronic hepatitis B
Authors: X. Liu, J.M. Chen, J.L. Lou, Y.X. Huang, Y. Yan, G.Z. Sun and N. Li
he aim of this study was to investigate the diagnostic value of the serum markers HBsAg and HBeAg and PreS1 protein (PreS1-Ag) in quantifying the levels of hepatitis B virus (HBV) DNA in patients with chronic hepatitis B (CHB). One thousand CHB patients were recruited from Beijing You’an Hospital between June and Decembe.. Read More»
- Genet. Mol. Res. 15(2):
Effect of the house dust mite allergen Der p 1 on tryptase release from human mast cells
Authors: D.Q. Wang, Y.Y. Shen, J.H. Xu and H. Tang
This study aimed to investigate the effects of the house dust mite allergen Der p 1 on the secretion of tryptase from the human mast cell line HMC-1. Flow cytometry was used to determine the expression levels of protease-activated receptor-2 (PAR2) on the surface of HMC-1 cells. HMC-1 cells were treated with Der p 1, SLIGRL-NH.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028284
- DOI:
- 10.4238/gmr.15028284