Effect of IL-17 monoclonal antibody Secukinumab combined with IL-35 blockade of Notch signaling pathway on the invasive capability of hepatoma cells
Authors: H.CH. Li, Y.X. Zhang, Y. Liu and Q.SH. Wang
We investigated the effect of the IL-17 monoclonal antibody Secukinumab combined with IL-35 in the blockade of the Notch signaling pathway on the invasive capability of hepatoma cells. We examined the effects of IL-17 antibody or IL-35 treatment alone or in combination on cell invasion and migration capabilities with Transwell.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028174
- DOI:
- 10.4238/gmr.15028174
HLA-A gene polymorphisms contribute to osteoporosis susceptibility in postmenopausal Han Chinese women
Authors: S.M. Li, H. Guo, H.J. Yang, M.Q. Lv and D.X. Zhou
Osteoporosis is a common disease characterized by low bone mineral density, deterioration in bone microarchitecture, and increased fracture risk and is more prevalent in postmenopausal women. HLA is a complex gene family; previous studies have shown that it plays an important role in the pathogenesis of osteoporosis among Japanese and Greek populations. P.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.18
- DOI:
- 10.4238/2015.August.28.18
Molecular-level effects of eribulin and paclitaxel on breast cancer based on differential co-expression network analysis
Authors: J. Qin and Y.H. Chen
We investigated the effects of eribulin and paclitaxel on breast cancer (BC) by exploring molecular biomarkers and pathways. Co-expression networks were constructed by differentially co-expressed genes and links, and centralities were analyzed to explore the hub genes. Pathway-enrichment analysis was performed. The hub genes w.. Read More»
- Genet. Mol. Res. 15(2):
Association of GSTP1 and XRCC1 gene polymorphisms with clinical outcomes of patients with advanced non-small cell lung cancer
Authors: J.Y. Liu, Q.M. Liu and L.R. Li
We investigated the association between the polymorphisms GSTP1 rs1695 and XRCC1 rs1799782 and rs25487 and the clinical outcome of patients with non-small cell lung cancer (NSCLC) receiving cisplatin-based chemotherapy. Genotyping of GSTP1 rs1695 and XRCC1 rs1799782, and rs25487 was conducted by polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.19
- DOI:
- 10.4238/2015.August.28.19
Effects of miR-26a on the expression of Beclin 1 in retinoblastoma cells
Authors: M. Li, X.M. Chen, D.M. Wang, L. Gan and Y. Qiao
The aim of this study was to evaluate the effects of miR-26a on Beclin 1 expression in retinoblastoma (RB) cell lines (Y79 and WERi-RB-1). RB cells were transfected with miR-26a mimic, antagomir-26a, or control mimic. The Beclin 1 mRNA and protein levels were detected by quantitative polymerase chain reaction and western blot,.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028193
- DOI:
- 10.4238/gmr.15028193
Association between TNF-�± -308G>A and -238G>A gene polymorphisms and TNF-�± serum levels in Mexican colorectal cancer patients
Authors: I.A. Guti�©rrez-Hurtado, A.M. Puebla-P�©rez, J.I. Delgado-Saucedo, L.E. Figuera, G.M. Z�º�±iga-Gonz�¡lez, K. Gomez-Mariscal,C.A. Ronquillo-Carre�³n and M.P. Gallegos-Arreola
The objective of this study was to examine the association between TNF-α serum levels and -308G>A and -238G>A polymorphisms in the corresponding gene by comparing healthy subjects to colorectal cancer (CRC) patients from a Mexican population. Serum levels of TNF-α were found to significantly differ between CR.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028199
- DOI:
- 10.4238/gmr.15028199
EDA mutation as a cause of hypohidrotic ectodermal dysplasia: a case report and review of the literature
Authors: S.X. Huang, J.L. Liang, W.G. Sui, H. Lin, W. Xue, J.J. Chen, Y. Zhang, W.W. Gong, Y. Dai and M.L. Ou
Ectodermal dysplasia (ED) represents a collection of rare disorders that result from a failure of development of the tissues derived from the embryonic ectoderm. ED is often associated with hair, teeth, and skin abnormalities, which are serious conditions affecting the quality of life of the patient. To date, a large number of genes have been found to be .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.21
- DOI:
- 10.4238/2015.August.28.21
Complete mitochondrial genome sequence and gene organization of Chinese indigenous chickens with phylogenetic considerations
Authors: F.P. Zhao, H.Y. Fan, G.H. Li and B.K. Zhang
In this study, we sequenced the complete mitochondrial DNA of Chinese indigenous Jinhu Black-bone and Rugao chickens. The two chicken mitochondrial genomes were deposited in GenBank under accession Nos. KP742951 and KR347464, respectively. The complete mitochondrial genomes of Jinhu Black-bone and Rugao chickens were sequenced.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028200
- DOI:
- 10.4238/gmr.15028200
Differential expression of glypican-3 (GPC3) in lung squamous cell carcinoma and lung adenocarcinoma and its clinical significance
Authors: X. Yu, Y. Li, S.W. Chen, Y. Shi and F. Xu
In this study, we examined the expression of glypican-3 (GPC3) in the 2 most common histological types of lung cancer, squamous cell carcinoma and adenocarcinoma, and explored the relationship between GPC3 expression and the prognosis of these 2 types of lung cancers. Lung cancer tissues and paracancerous tissues were collected from a total of 60 patients.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.2
- DOI:
- 10.4238/2015.August.28.2
Correlation between polymorphisms in the visfatin gene and its expression in the serum and coronary artery calcification
Authors: L.W. Jin, S.B. Zheng, Z.H. Zhou, S.F. Pan and Y. Zheng
We investigated the association between serum visfatin levels and single nucleotide polymorphisms (SNPs; rs61330082, rs2058539) in the visfatin gene and coronary artery calcification (CAC) in patients from Wenzhou, China. CAC patients (N = 206) were divided into two groups: mild CAC (MCAC) and moderate and severe CAC (MSCAC). .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028217
- DOI:
- 10.4238/gmr.15028217