Inhibitory effect of microRNA-27b on interleukin 17 (IL-17)-induced monocyte chemoattractant protein-1 (MCP1) expression
Authors: K.D. Huang, Y. Shen, X. Wei, F.Q. Zhang, Y.Y. Liu and L. Ma
We investigated the effect of microRNA-27b (miR-27b), a gene expression regulatory factor, on the expression of monocyte chemoattractant protein-1 (MCP1) stimulated by interleukin 17 (IL-17). After IL-17 had been added to H9C2 cardiomyocytes, an miR-27b mimic was transfected into the H9C2 cells. The mRNA expression levels of m.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027784
- DOI:
- 10.4238/gmr.15027784
Correlation between methylation of the E-Cadherin gene and malignancy of prostate cancer
Authors: S.Q. Zhang, G.Q. Zhang and L. Zhang
Prostate cancer is a common malignant tumor in males with an unclear pathogenic mechanism. As one epigenetic regulation mechanism, DNA methylation of the whole genome and specific gene(s) plays critical roles in pathogenesis, progression, diagnosis, and treatment of prostate cancer. The E-Cadherin gene is involved in cell meta.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028046
- DOI:
- 10.4238/gmr.15028046
Genomic characterization and sequence diversity of the ?²2-microglobulin gene in the miiuy croaker, Miichthys miiuy
Authors: Y.N. Sun, X.R. Su, T.J. Xu and T.W. Li
β2-Microglobulin (β2m) is related to major histocompatibility complex class I alpha chains, and forms cell-surface glycoproteins that mediate a variety of functions in immune defense. In general, β2m has no isoforms and is not polymorphic in higher vertebrates, but polymorphisms between different alleles have been found in some fish species.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.9
- DOI:
- 10.4238/2015.August.28.9
Androgen receptor (CAG)n polymorphisms and breast cancer risk in a Han Chinese population
Authors: J. Dang, L. Peng, H.J. Zhong and Z.H. Huo
The androgen receptor (AR) is involved in the differentiation and growth of breast cancer. Genetic markers in the AR gene have a plausible role in modulating the risk of breast cancer. In this study, we studied the association of breast cancer and the trinucleotide repeat polymorphism (CAG)n in exon 1 of the AR gene in 202 patients with breast cancer and .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.10
- DOI:
- 10.4238/2015.August.28.10
Influence of the DCC gene on proliferation and carcinoembryonic antigen expression in the human colorectal cancer cell line SW1116
Authors: H.W. Jiang, J. Wang, H.J. Li, J.K. Peng, X.P. Gao and F. Chen
This study investigated the effects of stable transfection of the exogenous wild-type DCC gene on growth of the human colorectal carcinoma cell line SW1116 in vitro. The DCC gene was amplified from normal human colon tissue by reverse transcription-polymerase chain reaction and used to construct a recombinant expression plasmid, pcDNA3.1(+)-DCC. DCC-negat.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.12
- DOI:
- 10.4238/2015.August.28.12
Investigation of single nucleotide polymorphisms in phosphodiesterase 4D gene in Mongol and Han patients with ischemic stroke in Inner Mongolia
Authors: J.P. Shi, W.D. Chen, J.Q. Zhou, M.M. Xue, F. Xue, H.Z. Li and Z.P. Xu
We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Ha.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.13
- DOI:
- 10.4238/2015.August.28.13
Whole-transcriptome sequencing of Pinellia ternata using the Illumina platform
Authors: X. Huang, Y. Jing, D.J. Liu, B.Y. Yang, H. Chen and M. Li
Pinelliae rhizoma is the dried tuber of Pinellia ternata (Thunb.) Breit., and has been used for thousands of years as a traditional Chinese medicine. However, its genomic background is little known. With the development of high-throughput genomic sequencing, it is now easy and cheap to obtain genomic information. In this study.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028062
- DOI:
- 10.4238/gmr.15028062
Synonymous single nucleotide polymorphisms in the MC4R gene that are significantly associated with milk production traits in water buffaloes
Authors: T.X. Deng, C.Y. Pang, M.Q. Liu, C. Zhang and X.W. Liang
Melanocortin-4 receptor (MC4R) is associated with feed intake, growth, fatness, and carcass composition in many domestic animals. The aim of this study was to evaluate the association of single nucleotide polymorphisms (SNPs) in MC4R with milk production traits in water buffalo. Eight SNPs were identified by direct polymerase .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028153
- DOI:
- 10.4238/gmr.15028153
Populations of Erythrina velutina Willd. at risk of extinction
Authors: M.F.V. Melo, L.O. Gon?§alves, A.R.C. Rabbani, S.V. ?lvares-Carvalho, J.B. Pinheiro, M.I. Zucchi and R. Silva-Mann
The goal of this study was to characterize the structure of two natural populations of the coral tree using RAPD and ISSR markers. The study evaluated all individuals in two different areas in the northeastern region of Brazil: the first was in the riparian area, 10 km x 100 m along the edge of the lower São Francisco River, and the second was in t.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.28.15
- DOI:
- 10.4238/2015.August.28.15
Phylogenetic relationships of Pseudohynobius (Urodela, Hynobiidae) inferred from DNA barcoding analysis
Authors: Y.-Y. Zhao, L.-N. Su, Z.-M. Zhang and X.-Y. Wang
As a proven tool, DNA barcoding can identify species rapidly and unambiguously. In this study, we used mtDNA cyt b, COI, and 16s rRNA sequences of six species of Pseudohynobius, Protohynobius puxiongensis, Liua shihi, Ranodon sibiricus, and Pachyhynobius shangchengensis, to reconstruct the phylogenetic relationships using Baye.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028155
- DOI:
- 10.4238/gmr.15028155