Applying the Fisher score to identify Alzheimer�s disease-related genes
Authors: J. Yang, Y.L. Liu, C.S. Feng and G.Q. Zhu
Biologists and scientists can use the data from Alzheimer's disease (AD) gene expression microarrays to mine AD disease-related genes. Because of disadvantages such as small sample sizes, high dimensionality, and a high level of noise, it is difficult to obtain accurate and meaningful biological information from gene expressio.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028798
- DOI:
- 10.4238/gmr.15028798
Molecular cloning and expression analysis of heat shock protein 20 (HSP20) from the pearl oyster Pinctada martensii
Authors: Q.N. Lei, Y.Y. Wu, H.Y. Liang, Z.X. Wang, Z. Zheng and Y.W. Deng
Small heat shock proteins (HSPs) are molecular chaperones with ATP-independent properties. They are involved in a variety of physiological and stress processes. In this study, the full-length HSP 20 (HSP20) from Pinctada martensii, designated as PmHSP20, was obtained from hemocytes using rapid amplification of cDNA ends techno.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028799
- DOI:
- 10.4238/gmr.15028799
A simple real-time polymerase chain reaction (PCR)-based assay for authentication of the Chinese Panax ginseng cultivar Damaya from a local ginseng population
Authors: H. Wang, J. Wang2 and G. Li
Panax ginseng is one of the most important medicinal plants in the Orient. Owing to its increasing demand in the world market, cultivated ginseng has become the main source of medicinal material. Among the Chinese ginseng cultivars, Damaya commands higher prices and is grown in significant proportions among the local ginseng p.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028801
- DOI:
- 10.4238/gmr.15028801
Expression profiles of MMP-1 and TIMP-1 in lumbar intervertebral disc degeneration
Authors: B. Deng, J.Z. Ren, X.Q. Meng, C.G. Pang, G.Q. Duan, J.X. Zhang, H. Zou, H.Z. Yang and J.J. Ji
Lumbar intervertebral disc degeneration (IDD) is a common clinical pathology and has become a focus for research in recent years. Matrix metalloproteinases (MMPs) are enzymes responsible for the degradation of almost all extracellular matrix proteins (ECM). The over-expression of MMPs or tissue inhibitors of metalloproteinases (TIMPs) may disrupt the dyna.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.16
- DOI:
- 10.4238/2015.December.29.16
Association between ERCC1 and ERCC2 gene polymorphisms and chemotherapy response and overall survival in osteosarcoma
Authors: Z.H. Cao, H.P. Yin, N. Jiang and B. Yu
We aimed to evaluate the influence of four SNPs in ERCC1 and ERCC2 on the response to cisplatin-based treatment and on clinical outcome in patients with osteosarcoma. We identified 186 patients with osteosarcoma diagnosed between April 2009 and April 2011 who were eligible for inclusion in our study. Genotyping of ERCC1 rs11615, rs3212986, and rs2298881; .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.21
- DOI:
- 10.4238/2015.August.21.21
Relevance of sampling and DNA extraction techniques for the analysis of salivary evidence from bite marks: a case report
Authors: M.L. ChÃ?¡vez-Briones, R. HernÃ?¡ndez-CortÃ?©s, G. Jaramillo-Rangel and M. Ortega-MartÃ?Ânez
Bite mark evidence has been repeatedly found in criminal cases. Physical comparison of a bite mark to the teeth of available suspects may not always be possible. Experimental studies have shown that the analysis of DNA present in the saliva recovered from bite marks might help in the identification of individuals. However, the application of this approach.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.23
- DOI:
- 10.4238/2015.August.21.23
Levels of mannose-binding lectin in individuals with visceral leishmaniasis in the northeast region of Brazil
Authors: E.L. da Silva, M. Campos J�ºnior, S.G. Monteiro, G.C. Costa, A.L.P. Magalh�£es, M.D.C. Santos, A.J.M. Caldas and M.M.G. Pimentel
Visceral leishmaniasis (VL) is one of the seven priority endemic diseases in the world. The clinical outcome of many infections is not only dependent on the pathogenic organism, but also on the genetic variability of the host susceptibility to infection. Mannose-binding lectin (MBL) is a protein that plays an important role in the innate immune system. Th.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.29.18
- DOI:
- 10.4238/2015.December.29.18
In vivo determination of muscle-derived stem cells in rat corpus cavernosum
Authors: L.J. Xu, B.X. Xue, Y.X. Shan, D. Chen, J. Gao, D.R. Yang, C.Y. Sun and Y. Cui
The aim of this in vivo study was to determine the existence of muscle-derived stem cells (MDSCs) in rat corpus cavernosum. Immunohistochemical and RT-PCR analyses were performed to determine the expression of the stem cell markers (Sca-1, Oct4, and desmin) in Sprague-Dawley (SD) rats in different age groups (10 rats in each group). Sca-1 was mainly expre.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.1
- DOI:
- 10.4238/2015.August.21.1
Differential expression of luteinizing hormone receptor, androgen receptor and heat-shock protein 70 in the testis of long-distance transported mice
Authors: L.P. Sun, Y.P. Song, J.J. Liu, X.R. Liu, A.Z. Guo and L.G. Yang
Spermatogenesis, is a complex process of precisely regulated intracellular events, where it is affected by many factors. Long-distance transport of animals is one of the stressors that may influence spermatogenesis and sperm quality. The present study chose luteinizing hormone receptor (LHR), androgen receptor (AR), and heat-shock protein 70 (HSP70) as ou.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.4
- DOI:
- 10.4238/2015.August.21.4
Effect of continuous infusion of midazolam on immune function in pediatric patients after surgery
Authors: H.B. Lu, Y.P. Jia, Z.H. Liang, R. Zhou and J.Q. Zheng
The current study was performed to investigate the effects of midazolam on immune function in pediatric patients after surgery and possible mechanism involved. Patients who needed sedation for more than 2 consecutive days after undergoing surgery in the Pediatric Surgery Department of our hospital were enrolled for the study. Fifty-six patients (5-14 year.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.7
- DOI:
- 10.4238/2015.August.21.7