Genetic analysis of five sedentary fish species in middle Laranjinha River (upper Paran�¡ River basin): A case study
Authors: W. Frantine-Silva, D.G. Ferreira, R.H.C. Nascimento, J.F. Fracasso, J.E. Conte, F.P. Ramos, S. Carvalho and B.A. Galindo
Most studies of diversity and genetic structure in neotropical fish have focused on commercial species from large rivers or their reservoirs. However, smaller tributaries have been identified as an important alternative migratory route, with independent pools of genetic diversity. In this context, the present study aimed to evaluate genetic diversity and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.13
- DOI:
- 10.4238/2015.December.28.13
Evolutionary analysis of the ubiquitin gene of baculovirus and insect hosts
Authors: S.S. Ma, Z. Zhang, H.C. Xia, L. Chen, Y.H. Yang, Q. Yao and K.P. Chen
Baculovirus is the only virus that has been found to encode the ubiquitin protein. In this study, ubiquitin sequences from 16 insects and 49 viruses were collected and compared. The resulting sequences were aligned with virus genomes. Then MAGE 5.0, k-estimated software, as well as other software programs were used for systemic evolutionary, selection pre.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.2
- DOI:
- 10.4238/2015.August.21.2
Genetic diversity among different physiological traits of Sorghum bicolor cultivars of subtropical origin
Authors: S.O. Bafeel
The genetic diversity of Saudi locally growing sorghum (Sorghum bicolor) cultivars has not been thoroughly characterized. To understand the genomic patterns of diversification in Saudi sorghum cultivars (N = 7), random amplified polymorphic DNA (RAPD) was used as a rapid, inexpensive method for providing information regarding genomic variability below the.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.3
- DOI:
- 10.4238/2015.August.21.3
Association of the PPAR�³2 Pro12Ala polymorphism with increased risk of cardiovascular diseases
Authors: Y. Li, J. Zhu and J.Q. Ding
This meta-analysis investigated the correlation between the PPARγ2 Pro12Ala polymorphism and cardiovascular disease (CVD). Electronic database and manual searches were conducted to retrieve studies published relevant to the PPARγ2 Pro12Ala polymorphism and CVD. Rigorous inclusion and exclusion criteria were employed for selection of high-quali.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.15
- DOI:
- 10.4238/2015.December.28.15
PI3K-AKT pathway polymerase chain reaction (PCR) array analysis of epilepsy induced by type II focal cortical dysplasia
Authors: Y.X. Lin, K. Lin, X.X. Liu, D.Z. Kang, Z.X. Ye, X.F. Wang, S.F. Zheng, L.H. Yu and Z.Y. Lin
The aims of this study were to observe the differential expression of PI3K-AKT pathway-related genes in seizure-inducing brain lesions in type II focal cortical dysplasia, and to explore the relationship between gene expression and histological changes in dysplastic foci and their epileptogenic mechanism. Typical lesions in brain tissue from three patient.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.5
- DOI:
- 10.4238/2015.August.21.5
Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and gastric cancer susceptibility in a population of Northern Brazil
Authors: M.D. Ara�ºjo, B.N. Borges, S. Rodrigues-Antunes, R.M.R. Burbano and M.L. Harada
The folate metabolic pathway, which is involved in DNA synthesis and methylation, is associated with individual susceptibility to several diseases, including gastric tumors. In this study, we investigated four polymorphisms [thymidylate synthase enhancer region, single nucleotide polymorphism thymidylate synthase 5' (TS5'), TS3' untranslated region, and m.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.6
- DOI:
- 10.4238/2015.August.21.6
Effects of microwave ablation or its combination with whole-body chemotherapy on serum vascular endothelial growth factor levels in patients with stage IIIB/IV NSCLC
Authors: Y.H. Sun, P.Y. Song, Y. Guo, M. Pang, W.-N. He, W.H. Zhang and L.J. Sheng
We aimed to analyze the changes of serum vascular endothelial growth factor (VEGF) before and after microwave ablation (MWA) in patients with stage IIIB-IV non-small cell lung cancer (NSCLC), and to observe the effects of MWA combined with chemotherapy on short-term therapeutic efficacy and long-term survival. Concentrations of serum VEGF in 20 healthy su.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.8
- DOI:
- 10.4238/2015.August.21.8
Association of variants in renal salt reabsorption-related gene SLC12A3 with essential hypertension in a Mongolian population
Authors: J.Q. Liang, Y.G. Xi, C.Y. An and X.L. Su
Mounting evidence has implicated the SLC12A3 gene in essential hypertension. Here, we examined the potential associations of common variants of the SLC12A3 gene with blood pressure traits in Mongolians in China. Genomic DNA was extracted from 508 unrelated Mongolian patients with essential hypertension and 246 normotensive Mongolian subjects for genotypin.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.9
- DOI:
- 10.4238/2015.August.21.9
Effect of Bifidobacterium on the mRNA expression levels of TRAF6, GSK-3�², and microRNA-146a in LPS-stimulated rat intestinal epithelial cells
Authors: W. Zhou, Y. Yuan, J. Li, W.M. Yuan, L.G. Huang and S.W. Zheng
We investigated the effect of inactivated Bifidobacterium on the mRNA expression of TRAF6, GSK-3β, and microRNA-146a in lipopolysaccharide (LPS)-stimulated rat small intestinal epithelial cells (IEC-6s). IEC-6s were randomly divided into an LPS group, a culture supernatant group, and an inactivated bacteria group. After stimulation with LPS for 5 h, .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.11
- DOI:
- 10.4238/2015.August.21.11
Analysis of the relationship between peripheral blood T lymphocyte subsets and HCV RNA levels in patients with chronic hepatitis C.
Authors: Y. Huang, M.J. Zheng and Y.H. Xu
We investigated the relationship between peripheral blood T lymphocyte subsets and hepatitis C virus (HCV) RNA levels in patients with hepatitis C. Samples from 69 chronic hepatitis C (CHC) patients and 20 healthy controls were analyzed using quantitative polymerase chain reaction (PCR) to detect HCV RNA and flow cytometry to determine the expression leve.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.21.12
- DOI:
- 10.4238/2015.August.21.12