CpG ODN 1826 enhances radiosensitivity of the human lung cancer cell line A549 in a rat model
Authors: W. Yan, T.-Y. Sun, C.-M. Yang, M. Jia, J. Li, H.-L. Tang and Y.-F. Zhou
This study investigated the effects of CpG ODN1826 plus radiotherapy (RT) on tumor growth and angiogenesis of subcutaneous tumor in a rat model. Four treatment groups were tested in which rats were injected with 100 μL CpG ODN1826 (1 μg/μL) or 100 μL vehicle, with and without exposure to 8 Gy after 2 h. At 7 days after inoculation of lung canc.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.13
- DOI:
- 10.4238/2015.August.19.13
Genetic diversity of popcorn genotypes using molecular analysis
Authors: F.S. Resh, C.A. Scapim, C.A. Mangolin, M.F.P.S. Machado, A.T. do Amaral Jr., H.C.C. Ramos and M. Vivas
In this study, we analyzed dominant molecular markers to estimate the genetic divergence of 26 popcorn genotypes and evaluate whether using various dissimilarity coefficients with these dominant markers influences the results of cluster analysis. Fifteen random amplification of polymorphic DNA primers produced 157 amplified fragments, of which 65 were mon.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.16
- DOI:
- 10.4238/2015.August.19.16
Genetic analysis of maize kernel thickness by quantitative trait locus identification
Authors: S.S. Wen, G.Q. Wen, C.M. Liao and X.H. Liu
Kernel thickness is one of the most important traits in kernel structure, and is related to yield. To ascertain its genetic information more clearly, an immortal recombinant inbred line segregation population was used to map the quantitative trait loci (QTLs) for kernel thickness. As a result, two QTLs were identified on chromosome 9; both of them had neg.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.19
- DOI:
- 10.4238/2015.August.19.19
Expression of N-cadherin in myocardial tissues during the development of a rat heart
Authors: L.M. Mu, W.F. Wang, H. Zheng, Z.K. Guo and G.M. Zhang
We investigated the expression and distribution of N-cadherin during the development of a rat heart. Immunohistochemistry (IHC) was performed to detect the expression and distribution of N-cadherin in the myocardial tissues of rats at embryonic day 18 (E18d), postnatal day 5 (P5d), postnatal day 19 (P19d), postnatal day 40 (P40d), and postnatal year 1 (P1.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.22
- DOI:
- 10.4238/2015.August.19.22
APOA5 -1131T>C and APOC3 -455T>C polymorphisms are associated with an increased risk of coronary heart disease
Authors: Y. Sun, R.B. Zhou and D.M. Chen
The aim of this study was to investigate correlations between apolipoprotein A-V (APOA5) -1131T>C and apolipoprotein C-III (APOC3) -455T>C polymorphisms and coronary heart disease (CHD). PubMed, Ovid, Cochrane Library, Embase, China National Knowledge Infrastructure, and Wanfang databases were searched using combinations of keywords relating to thes.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.9
- DOI:
- 10.4238/2015.December.23.9
Expression pattern of JMJD1C in oocytes and its impact on early embryonic development
Authors: C.H. Li, Y. Gao, S. Wang, F.F. Xu, L.S. Dai, H. Jiang, X.F. Yu, C.Z. Chen, B. Yuan and J.B. Zhang
Cell reprogramming mediated by histone methylation and demethylation is crucial for the activation of the embryonic genome in early embryonic development. In this study, we employed quantitative real-time polymerase chain reaction (qRT-PCR) to detect mRNA levels and expression patterns of all known histone demethylases in early germinal vesicle stage and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.12
- DOI:
- 10.4238/2015.December.23.12
Effect of Ginkgo biloba extract on matrix metalloproteinase-3 expression in a rat model of chondrocyte injury
Authors: J.Z. Zeng, L.F. Ma, H. Meng, H.M. Yu, Y.K. Zhang and A. Guo
A rat model with cartilage chondrocyte injury was established using interleukin-1β (IL-1β) to investigate the effect of Ginkgo biloba extract (EGb) on matrix metalloproteinase-3 (MMP-3) expression. Rat chondrocytes were extracted and randomly divided into six groups: control group, IL-1β (model) group, IL-1β + dexamethasone group, and .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.15
- DOI:
- 10.4238/2015.December.23.15
Cloning and characterization of ADP-glucose pyrophosphorylase small subunit gene in Cyperus esculentus (yellow nutsedge)
Authors: C. Cheng, J. Hu, Y. Zhi, J.J. Su, X.K. Zhang and B.Q. Huang
ADP-glucose pyrophosphorylase (ADPGlcPPase) controls the first committed step of starch synthesis by catalyzing the biosynthesis of ADP-glucose from glucose-phosphate and ATP. It is a tetrameric protein consisting of two small and two large subunits. The small subunits have a catalytic function, while the large subunits regulate the enzyme activity. Cyper.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.18
- DOI:
- 10.4238/2015.December.23.18
Topological centrality-based identification of hub genes and pathways associated with acute viral respiratory infection in infants
Authors: X.Y. Liu, G.Q. Li, Y. Ma and L.J. Zhao
The objective of this study was to identify hub genes and pathways associated with acute respiratory infection (ARI) in infants based on gene expression profiles. Differentially expressed genes (DEGs) between ARI and normal (controls) infants were identified based on linear modeling of the microarray data using Limma package. A protein-protein interaction.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.21
- DOI:
- 10.4238/2015.December.23.21
DNA barcoding and phylogenetic relationships of genera Picoides and Dendrocopos (Aves: Picidae)
Authors: Z.H. Huang, F.Y. Tu and X.J. Liao
Picoides and Dendrocopos are two closely related genera of woodpeckers (family Picidae), and members of these genera have long been the subjects of phylogenetic debate. Mitochondrial cytochrome c oxidase subunit I (COI) is a powerful marker for the identification and phylogenetic study of animal species. In the present study, we analyzed the COI barcodes .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.24
- DOI:
- 10.4238/2015.December.23.24