Association of TNF-�±, CTLA4, and PTPN22 polymorphisms with type 1 diabetes and other autoimmune diseases in Brazil
Authors: N.A.C. Tavares, M.M.S. Santos, R. Moura, J. Ara�ºjo, R.L. Guimar�£es, S. Crovella and L.A.C. Brand�£o
Type 1 diabetes mellitus (T1D) is a complex disorder characterized by an autoimmune response against human pancreatic beta-cells. Patients with T1D can also develop a response toward one or more other factors, such as in autoimmune thyroiditis (AITD) and celiac disease (CD). In the presence of T1D + AITD, the patient is diagnosed with autoimmune polygland.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.42
- DOI:
- 10.4238/2015.December.28.42
Proline accumulation is a general response to abiotic stress in the date palm tree (Phoenix dactylifera L.)
Authors: M.W. Yaish
Plants exposed to certain abiotic stress conditions tend to produce the amino acid proline, which acts as an active osmolyte, a metal chelator, an antioxidant, and a signaling molecule. There is increasing evidence that proline accumulates in plants due to a wide range of abiotic stress, in particular high soil salinity and drought. Therefore, proline con.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.30
- DOI:
- 10.4238/2015.August.19.30
Expression of TRAIL and its receptor DR5 and their significance in acute leukemia cells
Authors: S.M. Chen, H. Sun, Y.F. Liu, J. Ma, Q.T. Zhang, J. Zhu and T. Li
We investigated the roles of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its receptor death receptor 5 (DR5) in the onset of acute leukemia and changes in their expression during chemotherapy. Bone marrow samples from 16 patients newly diagnosed with acute leukemia were collected before chemotherapy. Bone marrow samples from patien.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.3
- DOI:
- 10.4238/2015.December.28.3
Potential of berberine to enhance antimicrobial activity of commonly used antibiotics for dairy cow mastitis caused by multiple drug-resistant Staphylococcus epidermidis infection
Authors: X. Zhou, C. Yang, Y. Li, X. Liu and Y. Wang
Berberine is a plant alkaloid with antimicrobial activity against a variety of microorganisms. In this study, the antimicrobial properties of berberine against multi-drug resistant field isolates of Staphylococcus epidermidis were investigated using berberine alone or in combination with a commonly used antibiotics in veterinary clinics, including penicil.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.1
- DOI:
- 10.4238/2015.August.19.1
Molecular identification of the genus Thryssa based on DNA barcoding
Authors: C.-Y. Ma, H.-Y. Ma, Y. Ni, W. Wang and L.-B. Ma
DNA barcoding is an effective method for identifying species by analyzing one or a few short standardized DNA sequences. In this study, we examined the utility of mitochondrial cytochrome oxidase subunit I (COI) sequences as a DNA barcode for the identification of six species belonging to the genus Thryssa: T. dussumieri, T. hamiltonii, T. kammalensis, T... Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.28.5
- DOI:
- 10.4238/2015.December.28.5
Morphological study of rat skin flaps treated with subcutaneous dimethyl sulfoxide combined with hyperbaric oxygen therapy
Authors: K.G. Almeida, R.J. Oliveira, D.M. Dourado, E.A. Filho, W.S. Fernandes, A.S. Souza and F.H.S Ara�ºjo
This study investigated the effects of hyperbaric oxygen therapy (HBOT) and dimethyl sulfoxide (DMSO) in tissue necrosis, genotoxicity, and cell apoptosis. Random skin flaps were made in 50 male Wistar rats, randomly divided into the following groups. Control group (CT), wherein a rectangular skin section (2 x 8 cm) was dissected from the dorsal muscle la.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.3
- DOI:
- 10.4238/2015.December.23.3
Genetic diversity analysis of sweet kernel apricot in China based on SSR and ISSR markers
Authors: M.P. Liu, H.Y. Du, G.P. Zhu, D.L. Fu and W.Y. Tana
Simple sequence repeat (SSR) and inter-simple sequence repeat (ISSR) markers were used to evaluate genetic diversity among 22 sweet kernel apricot accessions and 12 cultivars in China to provide information on how to improve the utilization of kernel apricot germplasms. The results showed that 10 pairs of SSR primers screened from 40 primer pairs amplifie.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.4
- DOI:
- 10.4238/2015.August.19.4
Polymorphisms in the GHRL gene and their associations with traits of economic interest in beef cattle
Authors: C.U. Braz, G.M.F. Camargo, D.F. Cardoso, F.M.M. Gil, P.D.S. Fonseca, J.N.S.G. Cyrillo, M.E.Z. Mercadante, H.N. Oliveira and H. Tonhati
The hormone ghrelin is produced in the stomach wall, has an orexigenic function, stimulates growth hormone secretion, and affects the energy balance of the animal. Therefore, the ghrelin gene (GHRL) is considered to be a good candidate marker for the identification of traits of great economic importance in cattle, such as those associated with feed intake.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.6
- DOI:
- 10.4238/2015.December.23.6
Antimutagenic action of the triterpene betulinic acid isolated from Scoparia dulcis (Scrophulariaceae)
Authors: P.L. de Freitas, A.C.S. Dias, V.R. Moreira, S.G. Monteiro and S.R.F. Pereira
The mutagenic and antimutagenic activities of triterpene betulinic acid {3b-3-hydroxy-lup-20(29)-en-28-oic} isolated from the roots of Scoparia dulcis (Scrophulariaceae) were analyzed using the somatic mutation and recombination test (SMART) in the wings of Drosophila melanogaster. The mutagenic potential of betulinic acid was evaluated at 3 different con.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.7
- DOI:
- 10.4238/2015.August.19.7
Identification of conservation units of the hynobiid salamander Pachyhynobius shangchengensis
Authors: L.-N. Su, Y.-Y. Zhao, X.-M. Wu, H.-F. Zhang and X.-C. Li
The evolutionary significant units (ESUs) of the salamander Pachyhynobius shangchengensis (Hynobiidae) in the Dabieshan mountains, southeastern China, were identified based on mitochondrial DNA data. We used methods for detecting cryptic species, such as the minimum spanning tree, the automatic barcode gap discovery, and the generalized mixed Yule-coalesc.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.10
- DOI:
- 10.4238/2015.August.19.10