Effective sample selection for classification of pre-miRNAs
Authors: K. Han
To solve the class imbalance problem in the classification of pre-miRNAs with the ab initio method, we developed a novel sample selection method according to the characteristics of pre-miRNAs. Real/pseudo pre-miRNAs are clustered based on their stem similarity and their distribution in high dimensional sample space, respective.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1054
- DOI:
- 10.4238/vol10-1gmr1054
Structural modeling and analysis of dengue-mediated inhibition of interferon signaling pathway
Authors: B. Aslam,J. Ahmad,A. Ali,R.Z. Paracha,S.H.K. Tareen,S. Khusro,T. Ahmad,S.A. Muhammad,U. Niazi and V. Azevedo
Dengue virus (DENV) belongs to the family Flaviviridae and can cause major health problems worldwide, including dengue fever and dengue shock syndrome. DENV replicon in human cells inhibits interferon α and β with the help of its non-structural proteins. Non-structural protein 5 (NS5) of DENV is responsible for the proteasome-mediated degradati.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.28.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.28.4
DNA variation and polymorphism in Tunisian plum species (Prunus spp): contribution of flow cytometry and molecular markers
Authors: H. Ben Tamarzizt, D. Walker, S. Ben Mustapha, D. Abdallah, G. Baraket, A. Salhi Hannachi and S. Zehdi Azzouzi
Plums (Prunus spp) are among the most important stone fruit crops in the world. European (Prunus domestica) and Japanese (Prunus salicina) plums are characterized by different levels of ploidy. Because genetic variability is the prerequisite for any plant-breeding program, we aimed to establish the taxonomic status of Tunisian plums and study their geneti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.30
- DOI:
- 10.4238/2015.December.22.30
Assessment of CASP gene polymorphisms in periodontal disease
Authors: S.W. Kang, S.K. Kim, J.H. Chung and J.Y. Ban
Caspases (CASP) are intracellular proteases that play roles as mediators of apoptosis. Activation of caspase 3 is enhanced in chronic periodontitis. Thus, we hypothesized that single nucleotide polymorphisms (SNPs) of CASP genes might be associated with this condition in the Korean population. To investigate whether such polymorphisms might be involved in.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.33
- DOI:
- 10.4238/2015.December.22.33
Mutations in NPHS2 (podocin) in Mexican children with nephrotic syndrome who respond to standard steroid treatment
Authors: J.S. Carrasco-Miranda, R. Garcia-Alvarez, R.R. Sotelo-Mundo, O. Valenzuela, M.A. Islas-Osuna and N. Sotelo-Cruz
Human nephrotic syndrome has been related to mutations in glomerular proteins. Mutations in the NPHS2 gene that encodes podocin have been described as responsible for steroid-resistant nephrotic syndrome. It has been advised to test for NPHS2 mutations in parallel or before giving steroid treatment in nephrotic syndrome patients in order to avoid unnecess.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.24.1
- DOI:
- 10.4238/2013.June.24.1
Increased CD56+ NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion
Authors: Y. Gao and P.L. Wang
Recurrent spontaneous abortion (RSA) is reported to be associated with immune imbalance at the maternal-fetal interface. Immune cells in the decidual tissue are involved in maintaining immune tolerance during pregnancy; however, whether natural killer (NK) and T cells are altered in unexplained RSA (URSA) remains unknown. In this study, we compared the nu.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.36
- DOI:
- 10.4238/2015.December.22.36
A novel molecular marker for the study of Neotropical cichlid phylogeny
Authors: T.M.C. Fabrin, L.S. Gasques, S.M.A.P. Prioli and A.J. Prioli
The use of molecular markers has contributed to phylogeny and to the reconstruction of species’ evolutionary history. Each region of the genome has different evolution rates, which may or may not identify phylogenetic signal at different levels. Therefore, it is important to assess new molecular markers that can be used for phylogenetic reconstructi.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.22.39
- DOI:
- 10.4238/2015.December.22.39
Morphological and genetic variation of the pine shoot tunnel beetle Placusa pinearum (Staphylinidae) in China
Authors: J.-Y. Gao, B.-Z. Ji and S.-W. Liu
Placusa pinearum, a newly described beetle species found living in pine shoot tunnels bored by the pine tip moth, Dioryctria rubella (Pyralidae), has potential as a vector to transport biological agents for controlling this moth pest of pine trees because of the high degree of niche overlap (co-occurrence) between them. In order to help determine the suit.. Read More»
- Genet. Mol. Res. 12(2):
Decreased expression of tumor suppressive miR-874 and its clinical significance in human osteosarcoma
Authors: L.Q. Zhang, S.L. Sun, W.Y. Li , Z. Feng, X.Y. Xu, Q.S. Zhuang and J. Fang
Dysregulation of microRNAs (miRs) is associated with cancer development and progression and aberrant expression of miR-874 have been found in some types of cancer. However, the expression and function of miR-874 in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-874 in osteosarcoma tumorigenesis and development. The ex.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.23.19
- DOI:
- 10.4238/2015.December.23.19
Inactivation of putative PKS genes can double geldanamycin yield in Streptomyces hygroscopicus 17997
Authors: Y.H. Li, M. Li, W.Q. He, Y.G. Wang and R.G. Shao
The putative polyketide biosynthesis (PKS) genes cos10 and pg10 were inactivated by insertion of a kanamycin-resistance gene into the genome of the geldanamycin-producing strain, Streptomyces hygroscopicus 17997. The resultant inactivation were confirmed by PCR analysis. The abilities of the PKS gene inactivation strains to produce geldanamycin were compa.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.21.3
- DOI:
- 10.4238/2013.June.21.3