Mutation characteristics in type I collagen genes in Chinese patients with osteogenesis imperfecta
Authors: Z. Yang, Z.F. Ke, C. Zeng, Z. Wang, H.J. Shi and L.T. Wang
Osteogenesis imperfecta is normally caused by an autosomal dominant mutation in the type I collagen genes COL1A1 and COL1A2. The severity of osteogenesis imperfecta varies, ranging from perinatal lethality to a very mild phenotype. Although there have been many reports of COL1A1 and COL1A2 mutations, few cases have been report.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr984
- DOI:
- 10.4238/vol10-1gmr984
Meiotic behavior in nonaploid accessions of Brachiaria humidicola (Poaceae) and implications for breeding
Authors: K.R. Boldrini, E.V. Adamowski, N. Silva, M.S. Pagliarini and C.B. Valle
Brachiaria humidicola is a grass adapted to seasonally swampy grasslands in Africa; two cultivars, ‘common’ and Llanero, are widely used in Brazilian pastures. New cultivars are in great demand in order to diversify current production systems to achieve improved quality and yield. Cytological analyses of 55 accessi.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr990
- DOI:
- 10.4238/vol10-1gmr990
SNP at miR-483-5p-binding site in the 3'-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population
Authors: H.Y. Li, Y.C. Liu, Y.H. Bai, M. Sun, L. Wang, X.B. Zhang and B. Cai
The aim of this study was to investigate the association between a functional variant of the basigin (BSG) gene, caused by a polymorphism (rs11473) at the miR-483-5p binding site, and the risk of esophageal squamous cell carcinoma (ESCC) in the Chinese population. The rs11473 polymorphism was genotyped in 624 esophageal cancer.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027735
- DOI:
- 10.4238/gmr.15027735
Leaf age affects the quality of DNA extracted from Dimorphandra mollis (Fabaceae), a tropical tree species from the Cerrado region of Brazil
Authors: P.A. Moreira and D.A. Oliveira
Isolation of high-quality DNA from plants, especially plants from the Cerrado, is notoriously difficult because of polysaccharides and secondary compounds produced by plants from this biome. DNA isolation and its quality may be compromised by chemical defenses such as tannins and phenols. Quantitative plant defenses tend to ha.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1030
- DOI:
- 10.4238/vol10-1gmr1030
Resistance of upland-rice lines to root-knot nematode, Meloidogyne incognita
Authors: D.C.T. Souza, F.B.S. Botelho, C.S. Rodrigues, I.V. Furtini, E.C. Smiderle, D.L. de Matos and A.T. Bruzi
Despite the benefits of crop rotation, occurrence of nematodes is a common problem for almost all crops within the Cerrado biome, especially for rice. The use of resistant cultivars is one of the main methods for control of nematodes. Thus, the present study aimed to evaluate the reaction of 36 upland-rice lines, with desirable agronomic characteristics, .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.7
- DOI:
- 10.4238/2015.December.21.7
Genomic ancestry evaluated by ancestry-informative markers in patients with sickle cell disease
Authors: A.F. Nascimento, J.S. Oliveira2, J.C. Silva Junior and A.A.L. Barbosa
The bs mutation is responsible for the most aggressive form of sickle cell disease, has a predominantly African origin, and arrived in Brazil through the slave trade. However, the Brazilian population is highly miscegenated, underscoring the importance of ancestry-informative markers (AIMs) for the identification of the geneti.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017604
- DOI:
- 10.4238/gmr.15017604
Critical genes in head and neck squamous cell carcinoma revealed by bioinformatic analysis of gene expression data
Authors: B. Wang, T. Wang, X.L. Cao and Y. Li
In this study, bioinformatic analysis of gene expression data of head and neck squamous cell carcinoma (HNSCC) was performed to identify critical genes. Gene expression data of HNSCC were downloaded from the Cancer Genome Atlas (TCGA) and differentially expressed genes were determined through significance analysis of microarrays. Protein-protein interacti.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.10
- DOI:
- 10.4238/2015.December.21.10
Cloning and characterization of a novel betaine aldehyde dehydrogenase gene from Suaeda corniculata
Authors: F.W. Wang, M.L. Wang, C. Guo, N. Wang, X.W. Li, H. Chen,Y.Y. Dong, X.F. Chen, Z.M. Wang and H.Y. Li
Glycine betaine is an important quaternary ammonium compound that is produced in response to several abiotic stresses in many organisms. The synthesis of glycine betaine requires the catalysis of betaine aldehyde dehydrogenase (BADH), which can convert betaine aldehyde into glycine betaine in plants, especially in halotolerant.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027848
- DOI:
- 10.4238/gmr.15027848
Three novel SNPs of the bovine Tf gene in Chinese native cattle and their associations with milk production traits
Authors: Z.H. Ju, Q.L. Li, J.M. Huang, M.H. Hou, R.L. Li, J.B. Li, J.F. Zhong and C.F. Wang
Transferrin (Tf) is a β-globulin protein that transports iron ions in mammalian cells. It contributes to innate immunity to microbial pathogens, primarily by limiting microbial access to iron. Thus, polymorphisms present in bovine Tf could potentially underlie inherited differences in mastitis resistance and milk producti.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1038
- DOI:
- 10.4238/vol10-1gmr1038
Genome-wide analysis of single nucleotide polymorphisms in patients with atrophic age-related macular degeneration in oldest old Han Chinese
Authors: T.Q. Zhou, H.J. Guan and J.Y. Hu
The aim of this study was to identify disease-associated loci in oldest old Han Chinese with atrophic age-related macular degeneration (AMD). This genome-wide association study (GWAS) only included oldest old (≥95 years old) subjects in Rugao County, China. Thirty atrophic AMD patients and 47 age-matched non-AMD controls were enrolled. The study subjec.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.13
- DOI:
- 10.4238/2015.December.21.13