Potential hippocampal genes and pathways involved in Alzheimer�s disease:a bioinformatic analysis
Authors: L. Zhang, X.Q. Guo, J.F. Chu, X. Zhang, Z.R. Yan and Y.Z. Li
Alzheimer’s disease (AD) is a neurodegenerative disorder and the most common cause of dementia in elderly people. Numerous studies have focused on the dysregulated genes in AD, but the pathogenesis is still unknown. In this study, we explored critical hippocampal genes and pathways that might potentially be involved in the pathogenesis of AD. Four t.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.15
- DOI:
- 10.4238/2015.June.29.15
Determination of self-incompatibility groups of sweet cherry genotypes from Turkey
Authors: A. Ipek, H. Gulen, M.E. Akcay, M. Ipek, S. Ergin and A. Eris
Determination of S-allele combinations of sweet cherry genotypes and cultivars has importance for both growers and breeders. We determined S-allele combinations of 40 local Turkish sweet cherry genotypes using a PCR-based method. Ten different S-alleles were detected. Although the most common S-allele was S3, as also found in .. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr1024
- DOI:
- 10.4238/vol10-1gmr1024
Expression and clinical value of the soluble major histocompatibility complex class I-related chain A molecule in the serum of patients with renal tumors
Authors: Y.-K. Zhao, C.-M. Jia, G.-J. Yuan, W. Liu, Y. Qiu and Q.-G. Zhu
We investigated the expression and clinical value of the soluble major histocompatibility complex class I-related chain A (sMICA) molecule in the serum of patients with renal tumors. Sixty patients diagnosed with renal tumors were enrolled in the experimental group, whereas 20 healthy volunteers served as the control group. The sMICA levels were measured .. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.16
- DOI:
- 10.4238/2015.June.29.16
RUNX3 promoter methylation correlation with pathogenesis of hepatocellular carcinoma in Asians
Authors: W. Lu, Y. Liu, L-L. Liu and P.-H. Zhuang
The aim of this study was to elucidate the role of RUNX3 promoter methylation in the pathogenesis of hepatocellular carcinoma (HCC) among Asians. For this purpose, we performed a comprehensive search of Chinese and English language scientific literature databases using stringent selection criteria; ultimately, we identified re.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027444
- DOI:
- 10.4238/gmr.15027444
Enzymatic differences between the endophyte Guignardia mangiferae (Botryosphaeriaceae) and the citrus pathogen G. citricarpa
Authors: A.S. Rom�£o, M.B. Sp�³sito, F.D. Andreote, J.L. Azevedo and W.L. Ara�ºjo
The endophyte Guignardia mangiferae is closely related to G. citricarpa, the causal agent of citrus black spot; for many years these species had been confused with each other. The development of molecular analytical methods has allowed differentiation of the pathogen G. citricarpa from the endophyte G. mangiferae, but the phys.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr952
- DOI:
- 10.4238/vol10-1gmr952
Involvement of the MAPK pathway in the pressure-induced synovial metaplasia procedure for the temporomandibular joint
Authors: M.J. Wu, H.P. Lu, Z.Y. Gu and Y.Q. Zhou
Abnormal pressure is an important factor that contributes to bone adaptation in the temporomandibular joint (TMJ). We determined the effect of the mitogen-activated protein kinases (MAPK) pathway on the pressure-induced synovial metaplasia procedure for the TMJ, both in vitro and in vivo. Synovial fibroblasts (SFs) were exacte.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027499
- DOI:
- 10.4238/gmr.15027499
Correlation of UGT1A1 and ERCC1 gene polymorphisms with the outcome of combined irinotecan plus cisplatin treatment in recurrent ovarian cancer
Authors: Q. Xu, Y.Y. Ding, L.X. Song andJ.F. Xu
The aim of this study was to define the genotypes of UGT1A1 and ERCC1 and to examine their relationship with the efficacy and toxicity of a combination therapy of irinotecan and cisplatin in patients with advanced ovarian cancer. The allelic frequencies of the UGT1A1 and ERCC1 variants in a group of 89 patients with advanced ovarian cancer were determined.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.17
- DOI:
- 10.4238/2015.June.29.17
Fas-FasL expression and myocardial cell apoptosis in patients with viral myocarditis
Authors: T.F. Huang, X.H. Wu, X. Wang and I.J. Lu
The aim of the current study was to investigate Fas and FasL expression and myocardial cell apoptosis in viral myocarditis patients. Human heart specimens were selected from patients who were autopsied between February 2012 and February 2015; of these, 25 patients were diagnosed with viral myocarditis. Another 15 cases with no.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027607
- DOI:
- 10.4238/gmr.15027607
Vegetative compatibility and genetic analysis of Colletotrichum lindemuthianum isolates from Brazil
Authors: Q.L. Barcelos, E.A. Souza and K.J. Damasceno e Silva
The causal agent of common bean anthracnose, Colletotrichum lindemuthianum, has considerable genetic and pathogenic variability, which makes the development of resistant cultivars difficult. We examined variability within and between Brazilian pathotypes of C. lindemuthianum through the identification of vegetative compatibili.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr907
- DOI:
- 10.4238/vol10-1gmr907
Expression of recombinant human anti-TNF-�± scFv-Fc in Arabidopsis thaliana seeds
Authors: N. Yao, L. Ai, Y.Y. Dong, X.M. Liu, D.Z. Wang, N. Wang, X.W. Li,F.W. Wang, XK. Li, H.Y. Li and C. Jiang
Recombinant human anti-tumor necrosis factor (TNF)-α scFv-Fc was expressed in TKO mutant Arabidopsis thaliana seeds using plant-specific codons. Immunoblotting using a human IgG1 antibody detected the expression of anti-TNF-α proteins in plants. Results from qRT-PCR analysis demonstrated that the time of harvest si.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027726
- DOI:
- 10.4238/gmr.15027726