Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population
Authors: L. Mao, G.Y. Geng, W.J. Han, M.H. Zhao, L. Wu and H.L. Liu
To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction f.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027803
- DOI:
- 10.4238/gmr.15027803
Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population
Authors: X.Z. Li, J. Liu, Y.F. Shi, D. Ju, Y. Zhang and T.F. Yue
We investigated the genetic polymorphisms of three short tandem repeat (STR) loci, D18S53, D18S59, and D18S488, on chromosome 18 in fetuses from a Chinese Tianjin Han population. Sixty-four villus samples and 374 amniotic fluid samples were collected from fetuses. Quantitative fluorescence polymerase chain reaction was perform.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027820
- DOI:
- 10.4238/gmr.15027820
Association between ERCC5 gene polymorphisms and gastric cancer risk
Authors: B.W. Guo, L. Yang, R. Zhao and S.Z. Hao
We investigate the role of ERCC5 gene polymorphisms (rs17655 and rs751402) in the development of gastric cancer in a Chinese population. A total of 142 gastric cancer patients whose diagnoses were confirmed by pathology, and 274 control subjects were recruited from Tangshan Gongren Hospital between March 2013 and March 2015. G.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027828
- DOI:
- 10.4238/gmr.15027828
Improving production of extracellular proteases by random mutagenesis and biochemical characterization of a serine protease in Bacillus subtilis S1-4
Authors: X.C. Wang, H.Y. Zhao, G. Liu, X.J. Cheng and H. Feng
The feather is a valuable by-product with a huge annual yield produced by the poultry industry. Degradation of feathers by microorganisms is a prerequisite to utilize this insoluble protein resource. To improve the degrading efficiency of feathers, mutagenesis of the bacterium Bacillus subtilis S1-4 was performed. By combining.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027831
- DOI:
- 10.4238/gmr.15027831
Metastasis-associated gene 1 expression in human medulloblastoma and its association with invasion and metastasis in medulloblastoma Daoy cell lines
Authors: Y.S. Chen, S.P. Li, H. Xiao, Z.Y. Xie, M.X. Tan, B. Liu and W.M. Zhang
This study aims to investigate the expression of metastasis-associated gene 1 (MTA1) in human medulloblastoma, and its significance in the invasion and metastasis in a medulloblastoma cell line. Positive expression rate of MTA1 protein in medulloblastoma and adjacent normal tissues collected from 29 medulloblastoma patients was detected by immunohistochem.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027894
- DOI:
- 10.4238/gmr.15027894
Isolation and characterization of eight novel microsatellite markers in Acanthopagrus schlegelii
Authors: X.Q. Mao, Z.B. Li, Y. Yuan, Y.F. Ning, J.B. Shangguan,Y.S. Huang, M Yang and B.B. Li
Acanthopagrus schlegelii is a warm temperate demersal fish, which inhabits the sediment substrate or rocky reefs in shallow seas. As this fish is a nutritionally endowed species with good palatability, it is a highly valuable commercial species for aquaculture and has a long historical standing in Western Pacific countries. Be.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027902
- DOI:
- 10.4238/gmr.15027902
Overexpression of P-glycoprotein on fibroblast-like synoviocytes in refractory rheumatoid arthritis patients: a potential mechanism for multidrug resistance in rheumatoid arthritis treatment
Authors: Y.M. Liu, J.W. Chen, L.X. Chen, X. Xie and N. Mao
This study aims to investigate the role of P-glycoprotein (P-gp) expression level in drug resistance to disease-modifying anti-rheumatic drugs in refractory rheumatoid arthritis (RRA). We evaluated and compared the expression levels of P-gp in fibroblast-like synoviocyte (FLS) cells in patients with rheumatoid arthritis (RA) a.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027927
- DOI:
- 10.4238/gmr.15027927
Applicability of genetic polymorphism analysis for the diagnosis of Angelman syndrome and the correlation between language difficulties and disease phenotype
Authors: K. Wang, Y.T. Li and M. Hou
Angelman syndrome (AS) is a neurogenetic disorder caused by a defect in the expression of the maternally inherited ubiquitin protein ligase E3A (UBE3A) gene in chromosome 15. The most common genetic defects include maternal deletions in chromosome 15q11-13; however, paternal uniparental disomy and imprinting defects allow for .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027945
- DOI:
- 10.4238/gmr.15027945
Cloning and expression of the 4D8 gene from Hyalomma asiaticum tick
Authors: Z.Q. Liu, J. Xia, G.L. Wang and N. Kuermanali
Hyalomma asiaticum tick, an important ectozoic parasite causes tickle, pain, anemia, weight loss, and paralysis in its hosts, which include humans, cattle, sheep, horses, camels, and hares. The 4D8 gene can be a potential vaccine candidate antigen for H. asiaticum. In the present study, we cloned and expressed the 4D8 gene of .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027951
- DOI:
- 10.4238/gmr.15027951
Clinical analysis of cases of neonatal Streptococcus agalactiae sepsis
Authors: S.J. Zeng, X.S. Tang, W.L. Zhao, H.X. Qiu, H. Wang and Z.C. Feng
With the advent of antibiotic resistance, pathogenic bacteria have become a major threat in cases of neonatal sepsis; however, guidelines for treatment have not yet been standardized. In this study, 15 cases of neonatal Streptococcus agalactiae sepsis from our hospital were retrospectively analyzed. Of these, nine cases showed.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027962
- DOI:
- 10.4238/gmr.15027962