Genetic and epigenetic alterations induced by different levels of rye genome integration in wheat recipient
Authors: X.L. Zheng, J.P. Zhou, L.L. Zang, A.T. Tang, D.Q. Liu, K.J. Deng and Y. Zhang
The narrow genetic variation present in common wheat (Triticum aestivum) varieties has greatly restricted the improvement of crop yield in modern breeding systems. Alien addition lines have proven to be an effective means to broaden the genetic diversity of common wheat. Wheat-rye addition lines, which are the direct bridge ma.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028001
- DOI:
- 10.4238/gmr.15028001
Association between RNF41 gene c.-206 T > A genetic polymorphism and risk of congenital heart diseases in the Chinese Mongolian population
Authors: Y. Zhang, S.Q. Jin, W.X. Li, G.Q. Gao, K. Zhang and J.L. Huang
This study aimed to explore the association between ring finger protein 41 (RNF41) c.-206 T > A variant and susceptibility to congenital heart disease (CHD) in the Chinese Mongolian population. The association between RNF41 gene c.-206 T > A polymorphism and CHD was examined in two independent case-control studies consis.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028089
- DOI:
- 10.4238/gmr.15028089
Structure and genetic diversity of natural Brazilian pepper populations (Schinus terebinthifolius Raddi)
Authors: S.V. ?lvares-Carvalho, J.F. Duarte, T.C. Santos, R.M. Santos, R. Silva-Mann and D. Carvalho
In the face of a possible loss of genetic diversity in plants due the environmental changes, actions to ensure the genetic variability are an urgent necessity. The extraction of Brazilian pepper fruits is a cause of concern because it results in the lack of seeds in soil, hindering its distribution in space and time. It is imp.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028123
- DOI:
- 10.4238/gmr.15028123
Comments on the article â??Relative h-index to compare the scientific performance of researchersâ? by L.A.S. Dias
Authors: L. Egghe
The relative h-index, proposed by L.A.S. Dias, is not useful to compare the scientific performance of researchers. This is shown by examples. More adequate alternatives include the g-index and the R-index... Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.8
- DOI:
- 10.4238/2013.June.13.8
Selection of reference genes in canine uterine tissues
Authors: M. Du, X. Wang, Y.W. Yue, P.Y. Zhou, W. Yao, X. Li, X.B. Ding,X.F. Liu, H. Guo and W.Z. Ma
Real-time quantitative polymerase chain reaction (RT-qPCR) is usually employed in gene expression studies in veterinary research, including in studies on canine pyometra. Canine pyometra is a common clinical disease in bitches. When using RT-qPCR, internal standards, such as reference genes, are necessary to investigate relati.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028138
- DOI:
- 10.4238/gmr.15028138
Effect of parasitism of Diatraea saccharalis (Lepidoptera: Crambidae) larvae by the wasp Cotesia flavipes (Hymenoptera: Braconidae) in defense reactions against abiotic agents: production and encapsulation reaction
Authors: C.C.C. Nunes and T.L. Silva
This study aimed to determine prophenoloxidase (proPO) activation and nitric oxide (NO) production in the hemolymph of Diatraea saccharalis larvae non-parasitized and parasitized by the wasp Cotesia flavipes and/or inoculated with abiotic agent (Sephadex beads), during parasitism/inoculation, and related to larval age; the ultrastructure of the capsule fo.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.7
- DOI:
- 10.4238/2013.June.13.7
Ursodeoxycholic acid upregulates ERK and Akt in the protection of cardiomyocytes against CoCl2
Authors: N.I. Hanafi, A.S. Mohamed, J. Md Noor, N. Abdul Hamid Hasani, R. Siran, N.J. Osman, S. Ab Rahim and S.H. Sheikh Abdul Kadir
Ursodeoxycholic acid (UDCA) is used to treat liver diseases and demonstrates cardioprotective effects. Accumulation of the plasma membrane sphingolipid sphingomyelin in the heart can lead to atherosclerosis and coronary artery disease. Sphingomyelinases (SMases) break down sphingomyelin, producing ceramide, and inhibition of S.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028150
- DOI:
- 10.4238/gmr.15028150
A systematic review of the intergenerational aspects and the diverse genetic profiles of Huntingtonâ??s disease
Authors: L.A. Agostinho, S.R. dos Santos, R.M.P. Alvarenga and C.L.A. Paiva
Huntington’s disease (HD) is a rare progressive and fatal neurogenetic degenerative disease, characterized by movement and personality disorders and by progressive dementia. Its prevalence varies by ethnic origin and different genetic profiles predisposing individuals to HD in each population. The prevalence of HD is 5-10 per 100,000 individuals in .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.June.13.6
- DOI:
- 10.4238/2013.June.13.6
Relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effects of pravastatin in patients with hyperlipidemia
Authors: T.N. Liu, C.T. Wu, F. He, W. Yuan, S.X. Li, H.W. Li, H.Y. Yu and M. Wu
In this study, we investigated the relationship between the G75A polymorphism in the apolipoprotein A1 (ApoA1) gene and the lipid regulatory effect of pravastatin in patients with hyperlipidemia. A total of 179 patients were divided into two groups: the pravastatin (N = 97) and policosanol (N = 82) treatment groups. The total .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028216
- DOI:
- 10.4238/gmr.15028216
Expression of glyceraldehyde 3-phosphate dehydrogenase is enhanced in Leishmania spp naturally resistant to nitric oxide
Authors: M.C. Rios, W.R.T. Silva, A.F. Azevedo, P.L. Santos, S.A. Teixeira, M.N. Muscar?¡, S.M. Thomazzi, R.P. Almeida, R.P.M. Fernandesand R. Scher
Leishmania spp are the causative agents of a spectrum of diseases termed leishmaniasis that affect mammals, including humans and dogs. Although reactive nitrogen species are employed in the control of parasitism by the immune system, it is known that Leishmania can withstand this oxidative stress. As the mechanism by which these species are resistant to n.. Read More»
- Genet. Mol. Res. 14(2):
- 2015.June.29.4
- DOI:
- 10.4238/2015.June.29.4