TNFR1-383 A��C polymorphism association with clinical manifestations in primary Sj�¶grenâ��s syndrome patients
Authors: A.L. Fletes-Rayas, C.A. Palafox-S�¡nchez, J.F. Mu�±oz-Valle,G. Orozco-Barocio, R.E. Navarro-Hern�¡ndez and E. Oregon-Romero
Primary Sjögren’s syndrome is an autoimmune disease affecting the function of exocrine glands. Tumor necrosis factor receptor-1 (TNFR1) is involved in apoptosis through extrinsic pathway initiation. The level of soluble TNFR1 is reported increased in rheumatoid arthritis, systemic lupus erythematosus, and primary Sj.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15024177
- DOI:
- 10.4238/gmr.15024177
Biological characterization of liver fatty acid binding gene from miniature pig liver cDNA library
Authors: Y.H. Gao, K.F. Wang, S. Zhang, Y.N. Fan, W.J. Guan and Y.H. Ma
Liver fatty acid binding proteins (L-FABP) are a family of small, highly conserved, cytoplasmic proteins that bind to long-chain fatty acids and other hydrophobic ligands. In this study, a full-length enriched cDNA library was successfully constructed from Wuzhishan miniature pig, and then the L-FABP gene was cloned from this cDNA library and an expressio.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.9
- DOI:
- 10.4238/2015.August.19.9
Expression of genes coding for selected amino acid transporters in small intestine, liver, and skeletal muscle of pigs fed excess branched-chain amino acids
Authors: M. Cervantes, N. Arce, H. GarcÃ?Âa, M. Cota, J.K. Htoo and A. Morales
Excess Leu reduces the availability of Ile and Val in pigs likely by reducing absorption of the latter amino acids (AA). Twenty-four crossbred pigs were used to evaluate the effect of excess Leu alone or with surplus Ile and Val on the expression of cationic (b0,+AT and CAT1) and neutral (B0AT1) AA transporters in the small intestine, liver, and skeletal .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.11
- DOI:
- 10.4238/2015.August.19.11
Population structure and genetic diversity in Gynaikothrips uzeli (Thysanoptera: Phlaeothripidae): is there a correlation between genetic and geographic proximity?
Authors: A.L.S. Mascarenhas, A.M. Waldschmidt and J.C. Silva Jr.
Gynaikothrips uzeli (Thysanoptera: Phlaeothripidae) is a minuscule insect species, which forms galls, is subsocial, and parthenogenetic. It is associated with Ficus benjamina L. (Moraceae) and has a pantropical occurrence. The paucity of genetic studies on the order Thysanoptera led us to use inter-simple sequence repeat molecular marker to assess intra- .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.12
- DOI:
- 10.4238/2015.August.19.12
Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population
Authors: L.Y. Wang, P. Zhang, H.F. Wang, Z.W. Qin, K.B. Wei and X.A. Lv
Two single nucleotide polymorphisms (SNPs; TaqI and ApaI) in the vitamin D receptor (VDR) gene have been identified as risk factors for the progression of end-stage renal disease (ESRD). The purpose of our study was to confirm the reported association of these two SNPs with ESRD risk and progression of renal osteodystrophy in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026825
- DOI:
- 10.4238/gmr.15026825
Expression and clinical implications of enhancer of Zeste homolog 2 and p53 protein in squamous cell carcinoma and precancerous lesions in the cervix
Authors: H.M. Zhang, S.Q. Chen and S.Z. Yao
We investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) and p53 protein in cervical squamous cell carcinoma (SCC) and precancerous lesions. EZH2 and p53 expressions in SCC (168), cervical intraepithelial neoplasia (CIN)-I (19), CIN-II (35), and normal tissues (30) were detected by strepta.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027408
- DOI:
- 10.4238/gmr.15027408
Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression
Authors: J.L. Zheng, B.S. Li, X.C. Cao, W.K. Zhuo and G. Zhang
Ginkgolide B has been known to inhibit cell apoptosis by modulating multiple cytokines and plays an important role in neuroprotection. Signal transducer and activator of transcription 1 (STAT1) has been studied in a spinal cord injury (SCI) model. However, the role of Ginkgolide B in SCI treatment remains unclear. This study i.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027673
- DOI:
- 10.4238/gmr.15027673
Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis
Authors: M. Kuang, W. Xu, C.X. Cao, L.L. Shen, J. Chang, X.L. Zhang, J.F. Chen and C.J. Tang
Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this me.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027771
- DOI:
- 10.4238/gmr.15027771
Interleukin-6 (IL-6) -174G/C genomic polymorphism contribution to the risk of coronary artery disease in a Chinese population
Authors: L. Mao, G.Y. Geng, W.J. Han, M.H. Zhao, L. Wu and H.L. Liu
To investigate the role of IL-6 polymorphism (-174G/C and -572C/G) in the development of coronary artery disease (CAD), CAD patients (224) and control subjects (260) were recruited between January 2012 and December 2014. Genotyping at IL-6 -174G/C and -572C/G was conducted via polymerase chain reaction coupled to restriction f.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027803
- DOI:
- 10.4238/gmr.15027803
Genetic polymorphisms of loci D18S53, D18S59, and D18S488 in fetuses from a Chinese Tianjin Han population
Authors: X.Z. Li, J. Liu, Y.F. Shi, D. Ju, Y. Zhang and T.F. Yue
We investigated the genetic polymorphisms of three short tandem repeat (STR) loci, D18S53, D18S59, and D18S488, on chromosome 18 in fetuses from a Chinese Tianjin Han population. Sixty-four villus samples and 374 amniotic fluid samples were collected from fetuses. Quantitative fluorescence polymerase chain reaction was perform.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027820
- DOI:
- 10.4238/gmr.15027820