Association between transcription factor 7-like 2 genetic polymorphisms and development of type 2 diabetes in a Chinese population
Authors: H.Y. Jia, Q.Z. Li and L.F. Lv
We conducted a hospital-based case-control study to evaluate the relationship between the transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism and type 2 diabetes mellitus risk in a Chinese population. Genotyping of TCF7L2 rs7903146 was carried out using the polymerase chain reaction-restriction fragment length polymo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15028223
- DOI:
- 10.4238/gmr.15028223
Identification of target genes for adenohypophysis-prefer miR-7 and miR-375 in cattle
Authors: B. Yuan, G.J. Sun, G.L. Zhang, J. Wu, C. Xu, L.S. Dai, J. Chen, X.F. Yu, Z.H. Zhao and J.B. Zhang
In this study, expression levels of miRNAs (miRNAs), miR-375 and miR-7, were detected in different tissues of cattle to determine whether adenohypophysis-prefer or exclusively expressed miRNAs, and target genes could be predicted by TargetScan, RNA22, and other software. Target genes related to pituitary function or reproductive traits were identified usi.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.8
- DOI:
- 10.4238/2015.August.19.8
TNFR1-383 A��C polymorphism association with clinical manifestations in primary Sj�¶grenâ��s syndrome patients
Authors: A.L. Fletes-Rayas, C.A. Palafox-S�¡nchez, J.F. Mu�±oz-Valle,G. Orozco-Barocio, R.E. Navarro-Hern�¡ndez and E. Oregon-Romero
Primary Sjögren’s syndrome is an autoimmune disease affecting the function of exocrine glands. Tumor necrosis factor receptor-1 (TNFR1) is involved in apoptosis through extrinsic pathway initiation. The level of soluble TNFR1 is reported increased in rheumatoid arthritis, systemic lupus erythematosus, and primary Sj.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15024177
- DOI:
- 10.4238/gmr.15024177
Biological characterization of liver fatty acid binding gene from miniature pig liver cDNA library
Authors: Y.H. Gao, K.F. Wang, S. Zhang, Y.N. Fan, W.J. Guan and Y.H. Ma
Liver fatty acid binding proteins (L-FABP) are a family of small, highly conserved, cytoplasmic proteins that bind to long-chain fatty acids and other hydrophobic ligands. In this study, a full-length enriched cDNA library was successfully constructed from Wuzhishan miniature pig, and then the L-FABP gene was cloned from this cDNA library and an expressio.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.9
- DOI:
- 10.4238/2015.August.19.9
Expression of genes coding for selected amino acid transporters in small intestine, liver, and skeletal muscle of pigs fed excess branched-chain amino acids
Authors: M. Cervantes, N. Arce, H. GarcÃ?Âa, M. Cota, J.K. Htoo and A. Morales
Excess Leu reduces the availability of Ile and Val in pigs likely by reducing absorption of the latter amino acids (AA). Twenty-four crossbred pigs were used to evaluate the effect of excess Leu alone or with surplus Ile and Val on the expression of cationic (b0,+AT and CAT1) and neutral (B0AT1) AA transporters in the small intestine, liver, and skeletal .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.11
- DOI:
- 10.4238/2015.August.19.11
Population structure and genetic diversity in Gynaikothrips uzeli (Thysanoptera: Phlaeothripidae): is there a correlation between genetic and geographic proximity?
Authors: A.L.S. Mascarenhas, A.M. Waldschmidt and J.C. Silva Jr.
Gynaikothrips uzeli (Thysanoptera: Phlaeothripidae) is a minuscule insect species, which forms galls, is subsocial, and parthenogenetic. It is associated with Ficus benjamina L. (Moraceae) and has a pantropical occurrence. The paucity of genetic studies on the order Thysanoptera led us to use inter-simple sequence repeat molecular marker to assess intra- .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.19.12
- DOI:
- 10.4238/2015.August.19.12
Association of vitamin D receptor gene polymorphisms with end-stage renal disease and the development of high-turnover renal osteodystrophy in a Chinese population
Authors: L.Y. Wang, P. Zhang, H.F. Wang, Z.W. Qin, K.B. Wei and X.A. Lv
Two single nucleotide polymorphisms (SNPs; TaqI and ApaI) in the vitamin D receptor (VDR) gene have been identified as risk factors for the progression of end-stage renal disease (ESRD). The purpose of our study was to confirm the reported association of these two SNPs with ESRD risk and progression of renal osteodystrophy in .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15026825
- DOI:
- 10.4238/gmr.15026825
Expression and clinical implications of enhancer of Zeste homolog 2 and p53 protein in squamous cell carcinoma and precancerous lesions in the cervix
Authors: H.M. Zhang, S.Q. Chen and S.Z. Yao
We investigated the expression and clinical implications of enhancer of Zeste homolog 2 (EZH2) and p53 protein in cervical squamous cell carcinoma (SCC) and precancerous lesions. EZH2 and p53 expressions in SCC (168), cervical intraepithelial neoplasia (CIN)-I (19), CIN-II (35), and normal tissues (30) were detected by strepta.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027408
- DOI:
- 10.4238/gmr.15027408
Alleviation of spinal cord injury by Ginkgolide B via the inhibition of STAT1 expression
Authors: J.L. Zheng, B.S. Li, X.C. Cao, W.K. Zhuo and G. Zhang
Ginkgolide B has been known to inhibit cell apoptosis by modulating multiple cytokines and plays an important role in neuroprotection. Signal transducer and activator of transcription 1 (STAT1) has been studied in a spinal cord injury (SCI) model. However, the role of Ginkgolide B in SCI treatment remains unclear. This study i.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027673
- DOI:
- 10.4238/gmr.15027673
Glutathione S-transferase P1 rs1695 A>G polymorphism and breast cancer risk: evidence from a meta-analysis
Authors: M. Kuang, W. Xu, C.X. Cao, L.L. Shen, J. Chang, X.L. Zhang, J.F. Chen and C.J. Tang
Breast cancer (BC) is the most widespread cause of cancer-related deaths in women. Many published studies have assessed the association between the glutathione S-transferase P1 (GSTP1) rs1695 polymorphism and BC risk. However, the effect of the GSTP1 rs1695 polymorphism on BC risk has remained controversial. Therefore, this me.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027771
- DOI:
- 10.4238/gmr.15027771