Effect of TIMP1 transfection on PTEN expression in human kidney proximal tubular cells
Authors: J.X. Chen, G.Y. Cai, X.M. Chen, H. Liu, X. Chen, Y.M. Peng, F.Y. Liu, Z. Li and S.Z. Shi
To explore the role of metalloproteinase-1 (TIMP-1) tissue inhibitor in the mechanisms of kidney aging, we observed the effects of sense and antisense transfection of TIMP-1 and of metalloproteinase (MMP) inhibitors on phosphatase and tensin homolog (PTEN), vascular endothelial growth factor (VEGF), and Flk-1 expression in TIMP-1 transgenic human proximal.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.6
- DOI:
- 10.4238/2015.December.21.6
Toll-like receptor 4 promotes fibrosis in bleomycin-induced lung injury in mice
Authors: X.X. Li, D.Y. Jiang, X.X. Huang, S.L. Guo, W. Yuan and H.P. Dai
The specific role of Toll-like receptor 4 (TLR4) in bleomycin-induced lung fibrosis of mice, a model of human idiopathic pulmonary fibrosis, has not been characterized. We injected bleomycin intratracheally into TLR4 knockout (TLR4-/-) and wild-type (WT) mice. Twenty-one days after injection, mice were sacrificed and their lungs were harvested for patholo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.8
- DOI:
- 10.4238/2015.December.21.8
Polymorphisms in the promoter regions of the CXCL1 and CXCL2 genes contribute to increased risk of alopecia areata in the Korean population
Authors: S.K. Kim, J-H. Chung, H.J. Park, S.W. Kang, D.-J. Lim, S.H. Byun, D.G. Baek, H.Y. Ko, B.-L. Lew, H.H. Baik and W.-Y. Sim
Alopecia areata (AA) is a common disease, which causes hair loss in humans. AA has a genetically complex inheritance. This study investigated the possible correlations between single nucleotide polymorphisms (SNPs) in the promoter regions of the chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1) and chemokine (C-X-C mot.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.29
- DOI:
- 10.4238/2015.August.14.29
A novel TSC1 mutation (c.1964delA) in a Chinese patient with tuberous sclerosis complex
Authors: G.-X. Wang, D.-W. Wang, J.-S. Zhao, S.-F. Wang and R.-P. Sun
Tuberous sclerosis complex is an autosomal-dominant heritable disease caused by mutations in the TSC1 and TSC2 genes. We studied a Chinese patient with sporadic tuberous sclerosis complex. The clinical features of this patient included epilepsy, hypomelanotic macules and angiofibromas on his back; a cranial CT scan showed sube.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr977
- DOI:
- 10.4238/vol10-1gmr977
Investigation into the association between NLRP3 gene polymorphisms and susceptibility to type 2 diabetes mellitus
Authors: S. Wang, F. Fang, W.B. Jin, X. Wang and X.S. Zheng
We conducted a case-control study to investigate the role of three common polymorphisms (rs10754558, rs7512998, and rs12137901) of the gene NLR family, pyrin domain containing 3 (NLRP3) in the development of type 2 diabetes mellitus (T2DM). Between May 2013 and May 2014, 385 patients with T2DM and 401 control subjects were enrolled in our study. Genotypin.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.15
- DOI:
- 10.4238/2015.December.21.15
Identification of sunflower (Helianthus annuus, Asteraceae) hybrids using simple-sequence repeat markers
Authors: A. Iqbal, H.A. Sadaqat, A.S. Khan and M. Amjad
Hybrid identification of 16 sunflower hybrids was confirmed using simple-sequence repeat methodology. Of 20 specific simple-sequence repeat primers, 18 authenticated the purity of these hybrids; the remaining two specific primer pairs gave ambiguous DNA fragments. The results indicate that simple-sequence repeat analysis for t.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr918
- DOI:
- 10.4238/vol10-1gmr918
Silencing FKBP38 gene by siRNA induces activation of mTOR signaling in goat fetal fibroblasts
Authors: Y.T. Fu, X. Zheng, Q. He, X.Y. Jia, Z.X. Guo, R.Y. Yao, Y.F. Wang and Z.G. Wang
FKBP38 (also known as FKBP8) is a unique member of the FK506-binding protein (FKBP) family, and its role is controversial because it acts as an upstream regulator of the mTOR signaling pathway, which controls cell growth, proliferation, and differentiation. This study aimed to explore the role of FKBP38 in the activation of mTOR signaling in Cashmere goat.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.30
- DOI:
- 10.4238/2015.August.14.30
Are Epichlo�« endophytes specific to Elymus grass hosts?
Authors: H. Song, Q.Y. Song, X.Z. Li and Z.B. Nan
Epichloë endophytes are widely distributed mutualists of cool-season grasses and can protect their hosts against biotic and abiotic stresses. Previous studies have shown that Epichloë endophytes are specific to their grass hosts in tall Festuca and Lolium species. However, no systematic analysis exists of host specificity of asexual Epichloë.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.17
- DOI:
- 10.4238/2015.December.21.17
Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction
Authors: Y.Y. Qiu, Y. Chen, T.H. Zeng, W.H. Guo, W.Y. Zhou and X.J. Yang
Chondrocytes, which are embedded within the growth-plate or the intervertebral disc, are sensitive to environmental stresses, such as inflammation and hypoxia. However, little is known about the molecular signaling pathways underlying hypoxia-induced mitochondrial dysfunction and apoptosis in chondrocytes. We first examined th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027755
- DOI:
- 10.4238/gmr.15027755
Akirin2 expression in response to vaccine-induced immunity in chicken
Authors: C.L. Man, W.T. Mu, Y. Chang and D.X. Zhao
Akirin2 is a nuclear factor that plays an important role in the development and regulation of innate immune response. In this study, akirin2 gene expression in several primary immune organs (liver, thymus, and bursa) of Hi-Line Brown chicken administered with the LoSota vaccine was analyzed during the various stages of increase in Newcastle disease virus .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.20
- DOI:
- 10.4238/2015.December.21.20