Expression and effect of serum interleukin-24 level on bone marrow mononuclear cells in children with acute leukemia
Authors: H.R. Cheng, B.Q. Wu, L. Chen, Z.X. Zhang and B. Li
To investigate the expression of interleukin-24 (IL-24) in the children with acute leukemia (AL) and its effect on the apoptosis of bone marrow mononuclear cells (BMMNCs) in vitro. Four groups were assessed: acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), non-leukemia, and healthy groups, 20 children in each group. ELISA was used to measur.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.28
- DOI:
- 10.4238/2015.December.16.28
Estimating genetic potential of biofuel forest hardwoods to withstand metal toxicity in industrial effluent under dry tropical conditions
Authors: S.A. Manzoor, S.N. Mirza, M. Zubair, W. Nouman, S.B. Hussain, S. Mehmood, A. Irshad, N. Sarwar, A. Ammar, M.F. Iqbal, A. Asim, M.U. Chattha, M.B. Chattha, A. Zafar and R. Abid
Biofuel tree species are recognized as a promising alternative source of fuel to conventional forms. Additionally, thesetree species are also effective in accumulating toxic heavy metals present in some industrial effluents. In developing countries such as Pakistan, the use of biofuel tree species is gaining popularity not only for harvesting economical a.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.17
- DOI:
- 10.4238/2015.August.14.17
Single-primer PCR correction: a strategy for false-positive exclusion
Authors: J. Ma, P.W. Wang, D. Yao, Y.P. Wang, W. Yan and S.C. Guan
Polymerase chain reaction (PCR) technology plays an important role in molecular biology research, but false-positive and nonspecific PCR amplification have plagued many researchers. Currently, research on the optimization of the PCR system focuses on double-primer-based PCR products. This research has shown that PCR amplificat.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr988
- DOI:
- 10.4238/vol10-1gmr988
Prognostic value of miR-141 downregulation in gastric cancer
Authors: Y.B. Lu, J.J. Hu, W.J. Sun, X.H. Duan and X. Chen
Previous research has shown that microRNA-141 (miR-141) expression levels are associated with survival in several types of cancer. In the present study, we investigated the clinical significance and prognostic value of miR-141 in gastric cancer. Paired tissue specimens (tumor and adjacent normal mucosa) from 95 patients with gastric cancer were obtained a.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.31
- DOI:
- 10.4238/2015.December.16.31
Assessment of genotoxicity of waterpipe smoking using 8-OHdG biomarker
Authors: M. Azab, O.F. Khabour, K.H. Alzoubi, S.A.H. Mahmoud, M. Anabtawi and M. Quttina
Waterpipe tobacco smoking is increasing in popularity, particularly among young adults. This popularity is related to the lack knowledge regarding the health effects of waterpipe smoking. In this study, we examined the genotoxicity of waterpipe smoking using an 8-hydroxy deoxyguanosine (8-OHdG) assay. Genotoxicity was evaluated in the saliva, urine, and s.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.18
- DOI:
- 10.4238/2015.August.14.18
Associations between HIF-1�± polymorphisms C1772T and G1790A and susceptibility to chronic obstructive pulmonary disease
Authors: W.T. Wei, B. Li, M. Chen, H.R. Jia and H.X. Zhang
In the present study, we examined whether hypoxia-inducible factor-1α (HIF-1α) polymorphisms are associated with the susceptibility to chronic obstructive pulmonary disease (COPD). One hundred and twenty patients with COPD and 112 healthy controls were recruited from the Han population in Southern China. Polymerase chain reaction-restriction f.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.21.2
- DOI:
- 10.4238/2015.December.21.2
Pathway-based network analysis of myeloma tumors: monoclonal gammopathy of unknown significance, smoldering multiple myeloma, and multiple myeloma
Authors: L. Dong, C.Y. Chen, B. Ning, D.L. Xu, J.H. Gao, L.L. Wang, S.Y. Yan and S. Cheng
Although many studies have been carried out on monoclonal gammopathy of unknown significances (MGUS), smoldering multiple myeloma (SMM), and multiple myeloma (MM), their classification and underlying pathogenesis are far from elucidated. To discover the relationships among MGUS, SMM, and MM at the transcriptome level, differentially expressed genes in MGU.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.20
- DOI:
- 10.4238/2015.August.14.20
Genetic diversity in local and commercial dry bean (Phaseolus vulgaris) accessions based on microsatellite markers
Authors: P.D.S. Cabral, T.C.B. Soares, A.B.P. Lima, F.D. de Miranda, F.B. Souza and L.S.A. Gon�§alves
Dry beans are considered to be a crop of great socio-economic importance, because they are an inexpensive source of nutrients and because their cultivation requires considerable manual labor. Studies of genetic diversity have been very important for genetic improvement programs, because they give parameters for the identificat.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr993
- DOI:
- 10.4238/vol10-1gmr993
Lack of association between potential prothrombotic genetic risk factors and arterial and venous thrombosis
Authors: F.C.G. Evangelista, D.R.A. Rios, D.D. Ribeiro, M.G. Carvalho, L.M.S. Dusse, A.P. Fernandes and A.P. Sabino
Recent studies have shown an association between thrombosis and factor VII (FVII), tissue factor (TF), and angiotensin-converting enzyme (ACE). This suggests that individuals with FVII-402 G/A, FVII-401 G/T, TF+5466 A/G, and ACE-287 insertion/deletion (I/D) polymorphisms present an increased risk of venous thrombosis, heart disease, and ischemic stroke co.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.14.21
- DOI:
- 10.4238/2015.August.14.21
Investigating paraoxonase-1 gene Q192R and L55M polymorphism in patients with renal cell cancer
Authors: O.A. Uyar, M. Kara, D. Erol, A. Ardicoglu and H. Yuce
Increased oxidative stress can help promote carcinogenesis, including development of renal cell carcinoma. The enzyme protects low-density lipoproteins from oxidation and can be a factor in this process. PON1 Q192R and L55M paraoxonase gene polymorphisms were assessed in 60 renal cell carcinoma patients and 60 healthy controls.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr927
- DOI:
- 10.4238/vol10-1gmr927