Modulatory effects of Duguetia furfuracea (A. St. Hil) Benth. and Hook. f. in Drosophila melanogaster somatic and germinative cells
Authors: L.S. Coelho, L.P. Felicio, C.T. Miranda, E.M. da Silva, C.R. Vale, D.C.S. Lima, S.R. Duarte, H.D. Ferreira, L. Chen Chen and S. Carvalho
Mutagenic and antimutagenic activities of the medicinal plant Duguetia furfuracea were assessed using SMART/wing and ring-X-loss tests. For the ring-X-loss test, 2- to 3-day-old Drosophila melanogaster ring-X-lineage males and virgin ywsn3 females received D. furfuracea infusion at doses of 0.085, 0.042, or 0.014 g/mL for 24 h.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr983
- DOI:
- 10.4238/vol10-1gmr983
Effect of baculovirus P35 protein on apoptosis in brain tissue of rats with acute cerebral infarction
Authors: J.F. Ji and X.H. Ma
We explored the effect of baculovirus P35 protein on apoptosis in the brain tissue of rats with acute cerebral infarction (ACI). A rat model of middle cerebral artery infarction was created. The rats were randomly divided into sham, model, and treatment groups. Baculovirus P35 protein was injected into the intracranial arteries of the treatment group rats.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.16
- DOI:
- 10.4238/2015.August.10.16
Novel exon nucleotide deletion causes adrenoleukodystrophy in a Brazilian family
Authors: E.R. Valadares*, A.L.C. Trindade*, L.R. Oliveira, R.R. Arantes, M.V. Daker, B.M. Viana, V.G. Haase, L.B. Jardim, G.C. Lopes and A.L.B. Godard
Adrenoleukodystrophy is a neurodegenerative X-linked recessive disorder. It is characterized by abnormal function of peroxisomes, which leads to an accumulation of very long-chain fatty acids in plasma and tissues, especially in the cortex of adrenal glands and white matter of the central nervous system, causing demyelinating .. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr975
- DOI:
- 10.4238/vol10-1gmr975
Aspergillus fumigatus diffusates suppress polymorphonuclear neutrophil phagocytic functions and respiratory burst levels in hematopoietic stem cell transplantation patients
Authors: X.H. Chen, Y.C. Deng, B.Y. Zhong and F. Hao
Invasive aspergillosis (IA) is a severe infection that commonly occurs in immunocompromised patients after hematopoietic stem cell transplantation (HSCT). The present study explores the effect of Aspergillus fumigatus diffusates (AfDs) on phagocytic function and superoxide anion (O2−) burst levels in polymorphonuclear neutrophils (PMNs) from post-HS.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.3
- DOI:
- 10.4238/2015.August.10.3
MicroRNA-21 promotes proliferation of rat hepatocyte BRL-3A by targeting FASLG
Authors: J.J. Li,W.H. Chan,W.Y. Leung,Y. Wang and C.S. Xu
Rat liver regeneration (RLR) induced by partial hepatectomy involves cell proliferation regulated by numerous factors, including microRNAs (miRNAs). miRNA high-throughput sequencing has been established and used to analyze miRNA expression profiles. This study showed that 39 miRNAs were related to RLR through the analysis of miRNA high-throughput sequenci.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.30
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.30
Allelic polymorphism, gene duplication and balancing selection of the MHC class II DAB gene of Cynoglossus semilaevis (Cynoglossidae)
Authors: T.J. Xu*, Y.N. Sun* and R.X. Wang
Major histocompatibility complex (MHC) genes play an important role in the immune response of vertebrates. Allelic polymorphism and evolutionary mechanism of MHC genes have been investigated in many mammals, but much less is known in teleosts. We examined the polymorphism, gene duplication and balancing selection of the MHC cl.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr960
- DOI:
- 10.4238/vol10-1gmr960
Investigation of polymorphisms in exon7 of the NSUN7 gene among Chinese Han men with asthenospermia
Authors: H.Y. Ren, R. Zhong, X.P. Ding, Z.Y. Chen and Y.L. Jing
Previous studies have shown that genetic polymorphisms in exon7 of the NSUN7 gene can be used as an infertility marker in Iranian men with asthenospermia. However, there have been no equivalent studies in China. In the present study, we investigated the possible association between the genetic polymorphisms in exon7 of NSUN7 and asthenospermia in a Chines.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.6
- DOI:
- 10.4238/2015.August.10.6
Confirmation of cross-fertilization using molecular markers in ornamental passion flower hybrids
Authors: L.D.H.C.S. Concei�§�£o, G.O. Belo, M.M. Souza, S.F. Santos, C.B.M. Cerqueira-Silva and R.X. Corr�ªa
Several interspecific Passiflora hybrids are produced in the northern hemisphere for the ornamental plant market. In Brazil, production of passion flower hybrids is limited to the introgression of genes into the main cultivated species, yellow passion fruit, to be used as rootstocks. Confirmation of hybridization in the initia.. Read More»
- Genet. Mol. Res. 10(1):
- vol10-1gmr894
- DOI:
- 10.4238/vol10-1gmr894
Cloning and transformation analysis of isoflavone synthase gene into Minshan Trifolium pratense
Authors: H.H. Hu, C.Q. Jing, R. Liu, W.D. Li and H.G. Feng
The aim of this study was to clone the isoflavone synthase (IFS) gene and establish the recombinant Minshan Trifolium pratense. The IFS gene was cloned from the callus of Minshan T. pratense using reverse transcription-polymerase chain reaction. The plant expression vector pRI101-AN-IFS was constructed and introduced into Agrobacterium tumefaciens strain .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.9
- DOI:
- 10.4238/2015.August.10.9
New compound heterozygous mutations of p. Thr101Ilefs*2 and p. Thr306Ale in a child from a Chinese family with 17�±-hydroxylase/17, 20-lyase deficiency
Authors: H. Xiao, H. Zhang, T. Li, D. Wu, L.T. Qin, T. Wang, B. Zhang and S.X. Liao
We determined whether a child with 17a-hydroxylase/17, 20-lyase deficiency possessed the sex-determining region (SRY) gene, and examined the mutations present in the CYP17A1 gene that led to 17a-hydroxylase/17, 20-lyase deficiency. In the child, karyotype analysis was performed and polymerase chain reaction analysis and electrophoretic techniques were use.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.12
- DOI:
- 10.4238/2015.August.10.12