Mating system patterns of natural populations of Pinus koraiensis along its post-glacial colonization route in northeastern China
Authors: X. Sui,F.J. Feng,D. Zhao,M. Xing,X.Y. Sun,S.J. Han and M.H. Li
To understand the genetic mechanisms underlying the endangerment of Pinus koraiensis, we studied the mating system of 49 families of this species in 3 natural populations along its post-glacial colonization route across ~1500 km in northeastern China using the chloroplast simple sequence repeat technique. We analyzed 11 polymorphic loci with clear and rep.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.26
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.26
A novel FBN1 heterozygous mutation identified in a Chinese family with autosomal dominant Marfan syndrome
Authors: Y. Yin1,X.-H. Liu2,X.-H. Li,N. Fan,D.-F. Lei,Y. Wang,S.-P. Cai,X.-M. Zhou,X.-M. Chen and X.-Y. Liu
The purpose of this study was to identify the clinical features and mutations in the fibrillin-1 gene (FBN1) in a large Chinese family with autosomal dominant Marfan syndrome (MFS). Seventeen members from a Chinese family of 4 generations were included in the study. All members underwent complete ophthalmic examination. Molecular genetic analysis was perf.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.27
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.27
Meta-analysis of microsomal epoxide hydrolase gene polymorphism and the risk of breast carcinoma
Authors: J.H. Zhong,L.Q. Li,X.S. Mo,W.F. Gong,L. Ma,J. Chen and X.-M. You
Carcinogenesis of breast carcinoma is very complicated. Previous studies have suggested conflicting results regarding the association between Tyr113His and His139Arg microsomal epoxide hydrolase (mEH) gene polymorphisms and risk of breast carcinoma. We conducted a meta-analysis to examine the relationship between these polymorphisms and breast carcinoma r.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.28
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.28
Highly specific detection of genetic modification events using an enzyme-linked probe hybridization chip
Authors: M.Z. Zhang, X.F. Zhang, X.M. Chen, X. Chen, S. Wu and L.L. Xu
The enzyme-linked probe hybridization chip utilizes a method based on ligase-hybridizing probe chip technology, with the principle of using thio-primers for protection against enzyme digestion, and using lambda DNA exonuclease to cut multiple PCR products obtained from the sample being tested into single-strand chains for hybridization. The 5'-end amino-l.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.10
- DOI:
- 10.4238/2015.August.10.10
Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to Alzheimer�s disease: a meta-analysis
Authors: Y.H. Lee and G.G. Song
The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer’s disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms. A total of 1359 patients.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.17
- DOI:
- 10.4238/2015.August.10.17
Association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction in a Hainan Chinese Han population
Authors: P. He, X.L.Chen and Y.P. Ding
We investigated the association between polymorphisms in the adiponectin gene (APM-1) and atherosclerotic cerebral infarction (ACI) in a Chinese Han population of Hainan Province. Polymerase chain reaction-restriction fragment length polymorphism and gene sequencing were used to analyze the distribution of APM-1 +45T/G and +276G/T genotypes and their alle.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.29
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.29
Telomere-associated factor expression in replicative senescence of human embryonic lung fibroblasts
Authors: H. Du, L. Yang, X.-Y. Xu, L. Hai, Y.-Q. Han and Y.-X. Shi
The objective of this study was to find the key regulatory molecules in the cell senescence process through observing the expression of telomere-associated factor during the normal cell replicative senescence process. Based on the established cell replicative senescence model, reverse transcription-polymerase chain reaction and western blot analyses were .. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.7
- DOI:
- 10.4238/2015.August.10.7
Protective effect of penehyclidine hydrochloride on lipopolysaccharide-induced acute kidney injury in rat
Authors: H.J. Cao, D.M. Yu, T.Z. Zhang, J. Zhou, K.Y. Chen, J. Ge and L. Pei
We aimed to observe the effect of penehyclidine hydrochloride (PHC) on lipopolysaccharide (LPS)-induced acute kidney injury in rats and expression of tight junction proteins ZO-1 and occludin. Adult male Sprague-Dawley (SD) rats were divided randomly (N = 10) into control group (C), LPS group (LPS), low-dose PHC group (L-PHC), and high-dose PHC group (H-P.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.14
- DOI:
- 10.4238/2015.August.10.14
Ectopic expression of the BoTFL1-like gene of Bambusa oldhamii delays blossoming in Arabidopsis thaliana and rescues the tfl1 mutant phenotype
Authors: H.Y. Zeng, Y.T. Lu, X.M. Yang, Y.H. Xu and X.C. Lin
TERMINAL FLOWER1 (TFL1) homologous genes play major roles in maintaining vegetative growth and inflorescence meristem characteristics in various plant species; however, to date, the function of the bamboo TFL1 homologous gene has not been described. In this study, a TFL1 homologous gene was isolated from Bambusa oldhamii and designated as BoTFL1-like. Phy.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.11
- DOI:
- 10.4238/2015.August.10.11
Effect of phosphatidylserine on memory in patients and rats with Alzheimer�s disease
Authors: Y.Y. Zhang, L.Q. Yang and L.M. Guo
The aim of this study was to investigate the effect of phosphatidylserine (PS) on memory of patients and rats with Alzheimer’s disease (AD). In total, 57 AD patients were recruited from our hospital, and were divided into two groups: 25 in the control group and 32 in the observation group. Next, 300 mg/d of PS was given to the rats in the observatio.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.10.13
- DOI:
- 10.4238/2015.August.10.13