Factors that influence the test day milk yield and composition
Authors: F.G. Silva, L.F. Brito, R.A. Torres, J.I. Ribeiro J�ºnior, H.R. Oliveira, G.C. Caetano and M.T. Rodrigues
The objective of this research was to study the factors that influence the test day milk yield (TDMY) and percentages of protein, fat, lactose, and total dry extract obtained on test day. We evaluated 110,732 weekly milk production records from 1496 goats and 19,271 monthly milk constituent records from 1245 Alpine and Saanen goats, which were collected f.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.13.5
- DOI:
- 10.4238/2013.13.5
Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299
Authors: G.M. Chen,R.F. Ding,Y.D. Tan,X.B. Pan,G.M. Jiang,J.F. He,S.H. Lin,C. Liu and Y. Jia
Casein kinase 2 interacting protein 1 (CKIP1) is a specific interacting protein of the casein kinase 2 (CK2) α subunit, and, by binding CK2 and other proteins, functions as an adaptor to regulate a series of cellular functions. Previous studies suggested that CKIP1 might play an important role in regulating oncogenic activities. However, few studies.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.15
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.15
Phenotypic correction and stable expression of factor VIII in hemophilia A mice by embryonic stem cell therapy
Authors: J.J. Wang, Y. Kuang, L.L. Zhang, C.L. Shen, L. Wang, S.Y. Lu, X.B. Lu, J. Fei, M.M. Gu and Z.G. Wang
Hereditary deficiency of factor VIII (FVIII) leads to hemophilia A, a severe X-linked bleeding disorder. Current therapies include fixed-dose FVIII prophylaxis, factor replacement therapy, and most recently, gene therapy. Prophylaxis and FVIII replacement therapies are limited by incomplete efficacy, high cost, restricted availability, and development of .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.May.13.4
- DOI:
- 10.4238/2013.May.13.4
Association of LRP5 Ala1330Val polymorphism with fracture risk: a meta-analysis
Authors: J. Peng, Y. Lu, Y.J. Liu and Y.L. Zhan
Numerous studies have evaluated the association between the Ala1330Val polymorphism of the low-density lipoprotein receptor-related proteins 5 (LRP5) gene and fracture risk. However, the specific association is still controversial. The aim of this study was to investigate their correlation via meta-analysis. and EMBASE databases were searched, and data we.. Read More»
- Genet. Mol. Res. 15(1):
- gmr.15017552
- DOI:
- 10.4238/gmr.15017552
Angiotensin-converting enzyme gene polymorphism (insertion/deletion) and liver fibrosis in Turkish patients from the western Black Sea region, Turkey
Authors: N.K. Turhan, S. Uygun Ilikhan, A.C. Hamamcioglu, Y. Ustundag, A. Dursun and F. Kokturk
Chronic viral hepatitis B, chronic viral hepatitis C, non-alcoholic steatohepatitis, alcoholic liver disease, autoimmune hepatitis, primary biliary cirrhosis, and secondary biliary cirrhosis are important health issues worldwide. While an association between angiotensin-converting enzyme gene insertion/deletion (ACE gene I/D) polymorphism and liver fibros.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.8
- DOI:
- 10.4238/2015.December.16.8
Association of the C677T polymorphism in the methylenetetrahydrofolate reductase gene with breast cancer in a Mexican population
Authors: A. Ramos-Silva,L.E. Figuera,O.M. Soto-Quintana,A.M. Puebla-PÃ?©rez,R. RamÃ?Ârez-PatiÃ?±o,I. GutiÃ?©rrez-Hurtado,D.I. Carrillo-Moreno, G.M. ZÃ?ºÃ?±iga-GonzÃ?¡lez,I.P. DÃ?¡valos-RodrÃ?Âguez and M.P. Gallegos-Arreola
The methylenetetrahydrofolate reductase (MTHFR) gene plays an important role in the steps involved in the processing of amino acids. The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and t.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.16
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.16
Agrobacterium-mediated transformation of Fusarium proliferatum
Authors: J. Bernardi-Wenzel, M.C. Quecine, J.L. Azevedo and J.A. Pamphile
Fusarium proliferatum is an important pathogen that is associated with plant diseases and primarily affects aerial plant parts by producing different mycotoxins, which are toxic to humans and animals. Within the last decade, this fungus has also been described as one of the causes of red root rot or sudden death syndrome in so.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027944
- DOI:
- 10.4238/gmr.15027944
Hematological and biochemical changes in a Phrynops geoffroanus (Schweigger, 1812) population in response to environmental stressors
Authors: M.I.A. Silva
Turtles are among the most endangered vertebrate groups, and the main threats to populations are environmental pollution and habitat degradation. The species Phrynops geoffroanus, popularly known as “Geoffroy’s side-necked turtle”, has proliferated in polluted environments, where adverse conditions could infl.. Read More»
- Genet. Mol. Res. 10(2):
- vol10-2ta037
- DOI:
- 10.4238/vol10-2ta037
Analysis and clinical significance of microRNA-499 expression levels in serum of patients with acute myocardial infarction
Authors: C.H. Zhao,G.-C. Cheng,R.L. He,Y. Hong,Q.L. Wan,Z.-Z. Wang and Z.-Y. Pan
The aim of this study was to investigate the expression level of microRNA-499 and its clinical significance in serum of patients with acute myocardial infarction (AMI). We recruited 59 patients with AMI and 60 healthy individuals undergoing physical examination in our hospital during the same period as controls. Peripheral blood was drawn in the morning o.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.27.17
- DOI:
- http://dx.doi.org/10.4238/2015.April.27.17
Regulating effect of MMP-9 and TIMP-1 in pituitary adenoma invasion
Authors: J.H. Mao, H. Guo, N. Si, L. Qiu, L.F. Guo, Z.S. Sun, Y. Xiang, X.H. Yang, W.G. Zhao and W.C. Zhang
Pituitary adenomas can cause endocrine disorder and organ damage, with some aggressive ones leading to a high postoperative recurrence rate. The occurrence and development of these type of tumors is closely related with matrix metalloproteinases (MMPs) and endogenous specific tissue inhibitor of MMPs (TIMPs). In this study, the relationship between pituit.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.16.9
- DOI:
- 10.4238/2015.December.16.9