A structured sparse regression method for estimating isoform expression level from multi-sample RNA-seq data
Authors: L. Zhang and X.J. Liu
With the rapid development of next-generation high-throughput sequencing technology, RNA-seq has become a standard and important technique for transcriptome analysis. For multi-sample RNA-seq data, the existing expression estimation methods usually deal with each single-RNA-seq sample, and ignore that the read distributions ar.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027670
- DOI:
- 10.4238/gmr.15027670
Effects of Danhong injection on hemodynamics and the inflammation-related NF-�ºB signaling pathway in patients with acute cerebral infarction
Authors: Y. Jiang and Y.J. Lian
The objective of the current study was to investigate effects of Danhong injection on hemodynamics, inflammatory cytokines, and the NF-κB pathway in acute cerebral infarction. In total, 246 patients with acute cerebral infarction were divided into control (N = 121) and observation (N = 125) groups based on treatment. The control group underwent conv.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.21
- DOI:
- 10.4238/2015.December.14.21
Hepatic phosphoenolpyruvate carboxykinase expression after gastric bypass surgery in rats with type 2 diabetes mellitus
Authors: J. Wu, S.S. Hou, W. Wang, M. Yin, N. Cheng, L.L. Ge, J.J. Yin and J. Xu
The objective of this study was to investigate the mRNA expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) after gastric bypass surgery (GBS) in rats with type 2 diabetic mellitus (T2DM). Thirty-six male Goto-Kakizaki rats, aged 12 weeks, were randomly divided into the GBS, sham operation with diet restriction (SO), and sham operation alone (.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.22
- DOI:
- 10.4238/2015.December.14.22
Effects of HIF prolyl-hydroxylase-2 gene silencing on HCG-induced vascular endothelial growth factor expression in luteal cells
Authors: Z.H. Zhang, D.Z. Yin, X.S Pang and Z.C. Wang
Vascular endothelial growth factor (VEGF)-dependent angiogenesis plays a crucial role in corpus luteum formation and its functional maintenance in mammalian ovaries. We recently reported that activation of hypoxia-inducible factor (HIF)-1α signaling contributes to the regulation of VEGF expression in luteal cells (LCs) in response to human chorionic.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.2
- DOI:
- 10.4238/2015.December.14.2
Cloning, characterization, and expression of cadmium-induced metallothionein-2 gene from earthworm Pheretima aspergillum (E. Perrier)
Authors: L. Gong, W. Li, J. Li, W.E. Li, W.R. Wu and L.W. Yu
Metallothioneins (MTs) are ubiquitous metal-binding, cysteine-rich proteins, associated with metal accumulation and thus providing protection against toxic heavy metals such as cadmium (Cd). To investigate the mechanisms of enrichment of Cd in the earthworm Pheretima aspergillum, we isolated and cloned metallothionein-2 (MT-2) cDNA (538 bp) from P. asperg.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.5
- DOI:
- 10.4238/2015.December.14.5
Correlations between the COMT gene rs4680 polymorphism and susceptibility to ovarian cancer
Authors: W. Pan and H. Liao
The objective of this study was to perform a systematic review of the correlations between the single nucleotide polymorphism rs4680 in the catechol-O-methyltransferase (COMT) gene and susceptibility to ovarian cancer. A computer search was carried out for relevant case-control studies published between January 2000 to January 2014 in databases such as Ov.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.8
- DOI:
- 10.4238/2015.December.14.8
Improved Agrobacterium-mediated transformation and high efficiency of root formation from hypocotyl meristem of spring Brassica napus �Precocity� cultivar
Authors: X.X. Liu, S.R. Lang, L.Q. Su, X. Liu and X.F. Wang
Rape seed (Brassica napus L.) is one of the most important oil seed crops in the world. Genetic manipulation of rapeseed requires a suitable tissue culture system and an efficient method for plant regeneration, as well as an efficient transformation procedure. However, development of transgenic B. napus has been problematic, and current studies are limite.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.11
- DOI:
- 10.4238/2015.December.14.11
MicroRNA-26b inhibits osteosarcoma cell migration and invasion by down-regulating PFKFB3 expression
Authors: W.D. Zheng, F.L. Zhou and N. Lin
MicroRNAs regulate target gene expression and are involved in cell proliferation, apoptosis, differentiation, tumor invasion, and cancer stem cell regulation, among other processes. MicroRNA-26b (miR-26b) is closely related to tumor occurrence and development. In this study, we analyzed miR-26b expression in osteosarcoma tissue, its effect on Saos-2 osteo.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.14
- DOI:
- 10.4238/2015.December.14.14
Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer
Authors: Y. An , H. Li, K.J. Wang, X.H. Liu, M.X. Qiu, Y. Liao, J.L. Huang and X.S. Wang
The incidence of bladder cancer is closely associated with exposure to aromatic amines, that can cause cancer only after metabolic activation regulated by N-acetyl transferase 1 and 2 (NAT1 and NAT2). Many studies have indicated that slow acetylation of NAT2 increases the risk of bladder cancer. The major risk factor is tobacco smoke; however, some studie.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.17
- DOI:
- 10.4238/2015.December.14.17
Association of the interleukin-6 gene -572G/C polymorphism with cancer risk: a meta-analysis
Authors: Q. Zhao, B. Zhang, Y. Chen, M. Li, X. Zhao, H. Fan and S.M. Li
The -572G/C polymorphism in interleukin-6 (IL-6) gene is associated with the development of cancer. However, previous studies have shown conflicting results; therefore, the association must be verified by an appropriate meta-analysis. For this purpose, we performed a literature search of the PubMed database to identify all reports on association between t.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.20
- DOI:
- 10.4238/2015.December.14.20