Relationship between C-reactive protein levels and obstructive sleep apnea syndrome
Authors: Y.X. Tie, Y.Y. Fu, Z. Xu and Y. Peng
This study aims to determine the relationship between C-reactive protein levels and obstructive sleep apnea syndrome (OSAS). We recruited 30 OSAS patients into the observation group (OSAS group), and subdivided them into mild, moderate and severe groups according to the apnea hypopnea index. In addition, 20 normal individuals .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027808
- DOI:
- 10.4238/gmr.15027808
Genes associated with disc degeneration identified using microarray gene expression profiling and bioinformatics analysis
Authors: Y. Chen, K. Chen, M. Li, C. Li, H. Ma, Y.S. Bai, X.D. Zhu and Q. Fu
Disc degeneration is strongly associated with back or neck pain, sciatica, and disc herniation or prolapse. It places an enormous economic burden on society and can greatly affect quality of life. Alternative treatment approaches, such as genetic therapies, are urgently needed to slow or reverse the disc degeneration process. We downloaded gene expression.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.5
- DOI:
- 10.4238/2013.April.26.5
Serum cytokine modulation after Staphylococcus hyicus infection in BALB/c mice
Authors: Y. Li, L. Wang, L.Y. Zhang, Y.L. Liu, Z.Y. Jiang1, R.J. Cai and C.X. Song
Staphylococcal infection is a severe bacterial infection. Finding satisfactory predictable biological markers is essential for the treatment of this condition. In this study, we applied a 32-marker sandwich ELISA-based antibody array to evaluate cytokine changes in Staphylococcus hyicus-inoculated BALB/c mice at 24 and 48 h post infection. Among the cytok.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.16
- DOI:
- 10.4238/2015.December.11.16
Genetic diversity in fragmented populations of Populus talassica inferred from microsatellites: implications for conservation
Authors: X.H. Zhu, S.P. Cheng, T. Liao and X.Y. Kang
Populus talassica Kom. is an ecologically important species endemic to central Asia. In China, its main distribution is restricted to the Ili region in the Xinjiang Autonomous Region. An understanding of genetic diversity and population structure is crucial for the development of a feasible conservation strategy. Twenty-six hi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027899
- DOI:
- 10.4238/gmr.15027899
Bos taurus papillomavirus activity in peripheral blood mononuclear cells: demonstrating a productive infection
Authors: T.C. Melo, R.P. Araldi, N.S.D. Pessoa, P.L. de-S�¡-J�ºnior, R.F. Carvalho, W. Be�§ak and R.C. Stocco
Bovine papillomavirus (BPV) is an oncogenic virus with mucous and epithelial tropism. Possible productive virus infection in other tissues, such as blood, has been hypothesized. In order to investigate this possibility, three samples of skin papillomas and blood were collected from bovines with BPV infection and five samples of peripheral blood and one sa.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.19
- DOI:
- 10.4238/2015.December.11.19
Evaluation of the stability of reference genes in bone mesenchymal stem cells from patients with avascular necrosis of the femoral head
Authors: X.N. Wang, Q.W. Yang, Z.W. Du, T. Yu, Y.G. Qin, Y. Song, M. Xu and J.C. Wang
This study aimed to evaluate 12 genes (18S, GAPDH, B2M, ACTB, ALAS1, GUSB, HPRT1, PBGD, PPIA, PUM1, RPL29, and TBP) for their reliability and stability as reference sequences for real-time quantitative PCR (RT-qPCR) in bone marrow-derived mesenchymal stem cells (BMSCs) isolated from patients with avascular necrosis of the femo.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027926
- DOI:
- 10.4238/gmr.15027926
Updated analysis of studies on the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and Hashimoto�s thyroiditis risk
Authors: R. Ji, Y. Feng and W.W. Zhan
Published data on the association between the cytotoxic T-lymphocyte-associated antigen-4 gene A49G polymorphism and the risk for Hashimoto’s thyroiditis (HT) are inconclusive. A meta-analysis was performed to derive a more precise estimation. Published case-control studies in English or Chinese were identified. In total, 24 studies with 2295 cases .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.4
- DOI:
- 10.4238/2013.April.26.4
Decreased miR-134 expression and its tumor-suppressive function in human osteosarcoma
Authors: Y. Bao, L. Peng, J. Ma, K. Liu and W. Li
Dysregulation of microRNA (miR) is often associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, its expression and function in osteosarcoma remain unclear. The aim of this study was to explore the effects of miR-134 in osteosarcoma tumorigenesis and development. The expression le.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.4
- DOI:
- 10.4238/2015.December.14.4
Peroxidase is involved in Pepper yellow mosaic virus resistance in Capsicum baccatum var. pendulum
Authors: L.S.A. Gon�§alves, R. Rodrigues, M.S.S. Diz, R.R. Robaina, A.T. do Amaral J�ºnior, A.O. Carvalho and V.M. Gomes
Pathogenesis-related proteins (PRs) are among the defense mechanisms of plants that work as an important barrier to the development of pathogens. These proteins are classified into 17 families according to their amino acid sequences, serology, and/or biological or enzyme activity. The present study aimed to identify PRs associated with the pathosystem of .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.26.3
- DOI:
- 10.4238/2013.April.26.3
Blockage of cisplatin-induced autophagy sensitizes cervical cancer cells to cisplatin
Authors: W.M. Lin and Z.G. Li
Development of chemoresistance is a major obstacle that leads to the recurrence and progression of cervical cancer (CC). Autophagy, meaning, “eating of self”, has shown paradoxical functions in tumors. In this study, we first investigated the process of autophagy induction by cisplatin in CC cells. Next, we investigated the role of autophagy i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.14.18
- DOI:
- 10.4238/2015.December.14.18