Identification of microRNAs as diagnostic biomarkers in screening of head and neck cancer: a meta-analysis
Authors: M. Zhang, L.J. Zhao, W.Q. Liang and Z.P. Mao
Head and neck cancer (HNC) is one of the most prevalent cancers; it is often diagnosed at its advanced stage and has a low 5-year survival rate. Evidence suggests that noninvasive biomarker microRNAs (miRNAs) are valuable for early diagnosis of HNC. This meta-analysis assessed the diagnostic value of miRNAs in HNC detection. A systematic literature search.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.3
- DOI:
- 10.4238/2015.December.11.3
Distribution of constitutive heterochromatin in Triatoma melanocephala (Hemiptera, Triatominae)
Authors: K.C.C. Alevi, J.A. Rosa and M.T.V. Azeredo-Oliveira
In principle, Triatoma melanocephala was included in the Brasiliensis subcomplex on the basis of morphological parameters and geographical layout, since there were no other relevant data available in the literature. On the basis of karyotype, it has been proposed to exclude T. melanocephala, as well as of .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.2
- DOI:
- 10.4238/2014.September.29.2
Effects of cetuximab combined with afatinib on the expression of KDR and AQP1 in lung cancer
Authors: Y.H. Liu and W.L. Zhu
In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 c.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.12
- DOI:
- 10.4238/2015.December.11.12
Candidate genes for carcass traits in a tropical-adapted Brazilian composite beef breed
Authors: G. Veneroni-Gouveia, P.C. Tizioto, S.L.C. Meirelles, A.C. Santiago, M.M. Alencar and L.C.A. Regitano
Backfat thickness (BFT) and ribeye area (REA) are important production traits but, because they are measured late in the animal’s life, they have not been efficiently included in breeding programs. The aim of this study was to evaluate whether single nucleotide polymorphisms (SNPs) mapped to the leptin, PPARGC1A, PSMC1, CRH, and FABP4 genes, which i.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.14
- DOI:
- 10.4238/2015.December.11.14
Multifocal central nervous system hemangioblastoma: a case report and review of the literature
Authors: L.Z. Chu, Z.Z. Guan, J. Liu, H. Yang, X.L. Qi, M.G. Dong, Y.M. Chen, Y.N. Xiang and Y. Li
An effective therapy for multifocal central nervous system hemangioblastoma (CNS HB) is needed. Here, we report a case of multifocal CNS HB. A 43-year-old man was diagnosed with CNS HB by enhanced computed tomography and magnetic resonance imaging. Six solid tumors and one cystic nodule were detected in his cerebellum. The pat.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.3
- DOI:
- 10.4238/2014.September.29.3
Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis
Authors: P. Yuan, L. Yuan, B.L. Xu, C.Z. Wang, H.Z. Yang and Y. Li
The aim of this study was to evaluate the role of GSTM1 null/present, GSTT1 null/present, and GSTP1 polymorphisms in the clinical response to chemotherapy and treatment outcome of breast cancer. The GSTM1, GSTT1, and GSTP1 IIe105Val polymorphism genotypes were analyzed using polymerase chain reaction coupled with restriction fragment length polymorphism. .. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.15
- DOI:
- 10.4238/2015.December.11.15
New hybrids from peanut (Arachis hypogaea L.) and synthetic amphidiploid crosses show promise in increasing pest and disease tolerance
Authors: A.P. F�¡vero, J.G. P�¡dua, T.S. Costa, M.A. Gimenes, I.J. Godoy, M.C. Moretzsohn and M.D. Michelotto
The primary gene pool of the cultivated peanut (Arachis hypogaea L., allotetraploid AABB) is very narrow for some important characteristics, such as resistance to pests and diseases. However, the Arachis wild diploid species, particularly those from the section Arachis, still have these characteristics. To improve peanut crops, genes from the wild species.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.17
- DOI:
- 10.4238/2015.December.11.17
Expression and clinical significance of miR-122 and miR-29 in hepatitis B virus-related liver disease
Authors: T.J. Xing, D.F. Jiang, J.X. Huang and Z.L. Xu
MicroRNA molecules have been increasingly regarded as a diagnostic and prognostic marker of certain diseases. The aim of this study was to investigate the expression and clinical significance of miR-122 and miR-29 in liver disease related to hepatitis B virus infection. The serum levels of miR-122 and miR-29 in 20 patients wit.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.4
- DOI:
- 10.4238/2014.September.29.4
Influence of gender on ABCC2 expression in peripheral blood mononuclear cells
Authors: P. Sudchada, W. Chareanchim, A. Assawamakin, P. Thaipiya, W. Choochaimongkhol, N. Thiplui and P. Sukmangsa
It is known that several factors, including gender, may influence the expression of multidrug resistance associated proteins 2 (MRP2/ABCC2) in the peripheral blood mononuclear cells (PBMCs). This study aims to compare ABCC2 gene expression in PBMCs of healthy males and females. PBMCs were extracted from 48 females and 44 males, and gene expression was mea.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.18
- DOI:
- 10.4238/2015.December.11.18
Effect of isodillapiole on the expression of the insecticide resistance genes GSTE7 and CYP6N12 in Aedes aegypti from central Amazonia
Authors: V.S. Lima, A.C. Pinto and M.S. Rafael
The yellow fever mosquito Aedes (Stegomyia) aegypti is the main vector of dengue arbovirus and other arboviruses. Dengue prevention measures for the control of A. aegypti involve mainly the use of synthetic insecticides. The constant use of insecticides has caused resistance in this mosquito. Alternative studies on plant extracts and their products have b.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.20
- DOI:
- 10.4238/2015.December.11.20