Isolation and characterization of simple sequence repeat markers for the herbaceous species Phyla scaberrima (Verbenaceae)
Authors: C.L. Chaves, E.A. Ruas, C.F. Ruas, J. Delfini, N.C. Bejatto, B.D. G�³es and P.M. Ruas
Phyla scaberrima (Verbenaceae) is a herbaceous species distributed from Mexico to Panama. Because of its well-known sweet properties and other medicinal uses, this species is cultivated in South America and the Caribbean. Phyla scaberrima has been arbitrarily extracted from nature, resulting in a severe reduc.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.24
- DOI:
- 10.4238/2014.September.26.24
ERCC1 C118T polymorphism has predictive value for platinum-based chemotherapy in patients with late-stage bladder cancer
Authors: Z.C. Xu, H.Z. Cai, X. Li, W.Z. Xu, T. Xu, B. Yu, Q. Zou and L. Xu
This study aims to investigate the association between ERCC1 codon C118T polymorphism and the response rate of platinum-based chemotherapy in patients with late-stage bladder cancer. A total of 41 eligible patients histologically confirmed as having stage IV muscle-invasive transitional cell carcinoma of the bladder were treat.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027801
- DOI:
- 10.4238/gmr.15027801
Upregulated microRNA-301a in osteosarcoma promotes tumor progression by targeting CDC14A
Authors: Z. Ni, X.F. Shang, Y.F. Wang, Y.J. Sun and D.J. Fu
MicroRNAs (miRs) are associated with tumor progression in various cancers, such as gastric and hepatic carcinomas, and lung cancer. miR-301a is overexpressed and displays oncogenic activity in cancers. We investigated the biological involvement of miR-301a in osteosarcoma (OS). Quantitative real-time polymerase chain reaction .. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027807
- DOI:
- 10.4238/gmr.15027807
Screening and analyzing genes associated with Amur tiger placental development
Authors: Q. Li, T.F. Lu, D. Liu, P.F. Hu, B. Sun, J.Z. Ma, W.J. Wang, K.F. Wang, W.X. Zhang, J. Chen, W.J. Guan, Y.H. Ma and M.H. Zhang
The Amur tiger is a unique endangered species in the world, and thus, protection of its genetic resources is extremely important. In this study, an Amur tiger placenta cDNA library was constructed using the SMART cDNA Library Construction kit. A total of 508 colonies were sequenced, in which 205 (76%) genes were annotated and .. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.25
- DOI:
- 10.4238/2014.September.26.25
Clinical significance of CTHRC1 protein expression in human cancers: a meta-analysis
Authors: S.F. Wang, Z. Yin, J.J. Yin, W. Zhang and C.G. Dong
The aim of this meta-analysis was to investigate the overall diagnostic and prognostic values of CTHRC1 expression in human cancer development. Based on the inclusion and exclusion criteria, 8 cohort studies were included in the meta-analysis. The data were extracted, and analyses were performed using a random-effects model. S.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027855
- DOI:
- 10.4238/gmr.15027855
Evaluation of the genotoxic activity of dicamba and atrazine herbicides in several Mexican and South American varieties of sweetcorn (Zea mays L.)
Authors: M.S. Reynoso, C.M. Alvarez, L. De la Cruz, M.D. Escoto and J.J.G. S�¡nchez
Corn is a major crop and various herbicides are used to maximize its production, which include a dicamba-atrazine mixture. This has great advantages, but can also induce DNA damage. Genotoxic activity was assessed by comet assay following application of two concentrations of dicamba-atrazine: 1000-2000 and 2000-4000 ppm. Apical meristem leaf nuclei from 1.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.5
- DOI:
- 10.4238/2015.December.11.5
Adaptability and stability of conilon coffee in areas of high altitude
Authors: D.H.G.S. Barbosa, W.P. Rodrigues, H.D. Vieira, F.L. Partelli and A.P. Viana
In view of the predicted models of global climate change and differences in prices and production costs, there is increased interest in Coffea canephora cultivation in areas of high altitude. However, this species is sensitive to low temperatures, where genotypes vary regarding adaptation/tolerance mechanisms, demonstrating ge.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.26
- DOI:
- 10.4238/2014.September.26.26
Prevalence of CYP2B6 polymorphisms in Argentinians: the role of genetic testing
Authors: P. Scibona, C. Vazquez, A.R. Cajal, P.F. Argibay and W.H. Belloso
CYP2B6 is a highly polymorphic isoenzyme involved in the metabolism of many drugs including cyclophosphamide, bupropion, and efavirenz. A single nucleotide polymorphism (SNP) in CYP2B6 (516G>T) resulted in decreased expression and function associated with the CYP2B6*6 haplotype. Among the clinical implications of this phenotype, decreased activation of.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.6
- DOI:
- 10.4238/2015.December.11.6
Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil
Authors: C.M.A.R. Barros, A.P. Araujo-Neto, T.R. Lopes, M.A.L. Barros, F.J.N. Motta, R. Canalle, L.C.C. Nunes, J.A. Rey, R.R. Burbano, M.A. Lima-Barros, F.K.N. Yoshioka and G.R. Pinto
Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have dem.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.29.1
- DOI:
- 10.4238/2014.September.29.1
Effect of human umbilical cord mesenchymal stem cells on endometriotic cell proliferation and apoptosis
Authors: L.N. Xu, N. Lin, B.N. Xu, J.B. Li and S.Q. Chen
The objective of this study was to observe the effects of human umbilical cord mesenchymal stem cells (UCMSCs) on the proliferation and apoptosis of endometriotic cells. Endometriotic cells and UCMSCs were primarily cultured in vitro. In the experimental group, a UCMSC and endometriotic cell non-contact co-culture system was established. The control group.. Read More»
- Genet. Mol. Res. 14(4):
- 2015.December.11.2
- DOI:
- 10.4238/2015.December.11.2