CTLA-4 and CD86 genetic variants and haplotypes in patients with rheumatoid arthritis in southeastern China
Authors: C.-P. Liu, J.-A. Jiang, T. Wang, X.-M. Liu, L. Gao, R.-R. Zhu, Y. Shen, M. Wu, T. Xu and X.-G. Zhang
The cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and costimulatory molecule (CD80/CD86) genes are important susceptibility genes associated with autoimmune diseases. CTLA-4 polymorphisms have been found to be associated with various autoimmune diseases. However, the association data are inconsistent for rheumatoid arthritis (RA). We investigated t.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.8
- DOI:
- 10.4238/2013.April.25.8
Implications of mitotic and meiotic irregularities in common beans (Phaseolus vulgaris L.)
Authors: D.C. Lima, G.T. Braz, G.B. dos Reis, V.H. Techio, L.C. Davide and A. de F.B. Abreu
The common bean has great social and economic importance in Brazil and is the subject of a high number of publications, especially in the fields of genetics and breeding. Breeding programs aim to increase grain yield; however, mitosis and meiosis represent under explored research areas that have a direct impact on grain yield... Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027749
- DOI:
- 10.4238/gmr.15027749
Genetic characterization of Fusarium graminearum and F. culmorum isolates from Turkey by using random-amplified polymorphic DNA
Authors: E. Y�¶r�¼k and G. Albayrak
Five Fusarium graminearum and 12 F. culmorum isolates, primarily pathogenic species of Fusarium head blight, were obtained from naturally infected wheat from various agro-ecological regions of Turkey. Genotyping of the isolates was carried out using random-amplified polymorphic DNA (RAPD). Sixty-five 10-mer oligonucleotide primers were used to amplify the.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.7
- DOI:
- 10.4238/2013.April.25.7
Nuclear magnetic resonance-based study reveals the metabolomics profile of nasopharyngeal carcinoma
Authors: Y. Wang, X. Luo, G.H. Zhang and S.L. Li
Proton nuclear magnetic resonance ([1H]-NMR) spectroscopy has been used to investigate metabolites in serum and several types of tissue. We used NMR spectroscopy to explore the differential metabolic profiles in serum from nasopharyngeal carcinoma (NPC) patients. Moreover, metabolites with potential as biomarkers for identifyi.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027796
- DOI:
- 10.4238/gmr.15027796
Evaluation of a histocompatibility antigen related to hepatitis B virus in patients with hepatocellular carcinoma in the western Brazilian Amazon
Authors: S.R.S. Chalub, R.M. da Silva, A.P.S. da Silva, P.F. de Aquino,A. Sadahiro and A.N. Kalil
Hepatocellular carcinoma is an infection of variable incidence that can be caused by hepatitis B virus (HBV), which is endemic in the Amazon region. The diagnosis of HBV can be performed through the use of serum markers such as the hepatitis B surface antigen. The chronic HBV can cause mutagenesis and carcinogenesis, being the susceptibility of infection .. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.5
- DOI:
- 10.4238/2013.April.25.5
HNF1b is involved in prostate cancer risk via modulating androgenic hormone effects and coordination with other genes
Authors: Y.L. Hu, D. Zhong, F. Pang, Q.Y. Ning, Y.Y. Zhang, G. Li, J.Z. Wu and Z.N. Mo
Prostate cancer is one of the most commonly diagnosed male malignancies. Genome wide association studies have revealed HNF1b to be a major risk gene for prostate cancer susceptibility. We examined the mechanisms of involvement of HNF1b in prostate cancer development. We integrated data from Gene Expression Omnibus prostate cancer genes from the Dragon Dat.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.4
- DOI:
- 10.4238/2013.April.25.4
Enhancement of recombinant adeno-associated virus mediated transgene expression by targeted echo-contrast agent
Authors: S.L. Yang, Y.M. Mu, K.Q. Tang, X.K. Jiang, W.K. Bai, E. Shen and B. Hu
Ultrasound-targeted microbubble destruction (UTMD) has been recently developed for destroying bubbles carrying drugs or genes, thereby permitting local release of these target molecules. We investigated whether SonoVue®, a new contrast agent that contains phospholipid-stabilized microbubbles filled with sulfur hexafluoride vapor, is effective at deliv.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.3
- DOI:
- 10.4238/2013.April.25.3
Smallest critical region for microcephaly in a patient with mosaic ring chromosome 13
Authors: P.-H. Su, C.-P. Chen, Y.-N. Su, S.-J. Chen, L.-L. Lin and J.-Y. Chen
A ring chromosome 13 or r(13) exhibits breakage and reunion at breakage points on the long and short arms of chromosome 13, with deletions of the chromosomal segments distal to the breakage points. The r(13) chromosome accounts for approximately 20% of ring chromosomes compatible with life. We describe a female patient with mental retardation, growth reta.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.2
- DOI:
- 10.4238/2013.April.25.2
Karyotype characterization reveals active 45S rDNA sites located on chromosome termini in Smilax rufescens (Smilacaceae)
Authors: D. Pizzaia, V.M. Oliveira, A.R. Martins, B. Appezzato-da-Gl�³ria, E. Forni-Martins and M.L.R. Aguiar-Perecin
The genus Smilax (Smilacaceae) includes species of medicinal interest; consequently, their identification is important for the control of raw material used in the manufacture of phytotherapeutic products. We investigated the karyotype of Smilax rufescens in order to look for patterns that would be useful for comparative studies of this genus. To accomplis.. Read More»
- Genet. Mol. Res. 12(2):
- 2013.April.25.1
- DOI:
- 10.4238/2013.April.25.1
Genetic diversity among Puccinia melanocephala isolates from Brazil assessed using simple sequence repeat markers
Authors: R.F. Peixoto-Junior, S. Creste, M.G.A. Landell, D.S. Nunes, A. Sanguino, M.F. Campos, R. Vencovsky, E.V. Tambarussi and A. Figueira
Brown rust (causal agent Puccinia melanocephala) is an important sugarcane disease that is responsible for large losses in yield worldwide. Despite its importance, little is known regarding the genetic diversity of this pathogen in the main Brazilian sugarcane cultivation areas. In this study, we characterized the gen.. Read More»
- Genet. Mol. Res. 13(3):
- 2014.September.26.23
- DOI:
- 10.4238/2014.September.26.23