Effects of siRNA-mediated silencing of Sal-like 4 expression on proliferation and apoptosis of prostate cancer C4-2 cells
Authors: K.F. Liu and Y.X. Shan
The aim of this study was to evaluate the effects of small interfering RNA (siRNA)-inhibited expression of the Sal-like 4 (SALL4) gene on the proliferation, colony formation, and apoptosis of prostate cancer C4-2 cells. C4-2 cells were cultured and divided into a si-SALL4 group, a negative control siRNA group, and a blank cont.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027885
- DOI:
- 10.4238/gmr.15027885
Relationship between genetic polymorphisms in MCP-1, CCR-2, and non-small-cell lung cancer in the Han nationality of Northern China
Authors: L. Yang,J. Wang,F.-G. Li,M. Han,X.-J. Chang and Z.-T. Wang
Lung cancer is a common malignant tumor worldwide and is now the leading cause of cancer-related deaths. Monocyte chemoattractant protein 1 (MCP-1) and its receptor chemokine receptor 2 (CCR-2) are important chemokines. We examined the polymorphisms of 338 unrelated patients with non-small cell lung carcinoma (NSCLC) and 200 unrelated healthy controls of .. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.2
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.2
MicroRNA-32 functions as a tumor suppressor and directly targets EZH2 in uveal melanoma
Authors: Y.B. Ma, D.W. Song, R.H. Nie and G.Y. Mu
MicroRNA-32 (miR-32) has been shown to be dysregulated in some human malignancies and this has been found to be correlated with tumor progression. However, its role in uveal melanoma formation and progression remains largely unknown. Thus, the aim of this study was to explore the expression and function of miR-32 in human uvea.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027935
- DOI:
- 10.4238/gmr.15027935
Investigating the prevention of hospital-acquired infection through standardized teaching ward rounds in clinical nursing
Authors: R. Zhang
This study aimed to explore the effect of standardized teaching ward rounds in clinical nursing on preventing hospital-acquired infection. The experimental group comprised 120 nursing students from our hospital selected between June 2010 and June 2012. The control group consisted of 120 nursing students selected from May 2008 to May 2010. Traditional teac.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.3
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.3
Biogeographic pattern of genetic diversity detected by RAPD and ISSR analysis in Gypsophila (Caryophyllaceae) species from Turkey
Authors: M. Korkmaz and N.Y. Dogan
Gypsophila L. is the 3rd-largest genus of Caryophyllaceae in Turkey, a country that includes 60 taxa belonging to 56 species of the 126 recognized in the genus. A total of 35 taxa are endemic to Turkey, with an approximately 60% endemism ratio. In this study, the genetic diversity of 14 Gypsophila species from Turkey was analyzed using random amplificatio.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.6
- DOI:
- 10.4238/2015.August.3.6
Impact of adherence to GOLD guidelines on 6-minute walk distance, MRC dyspnea scale score, lung function decline, quality of life, and quality-adjusted life years in a Shanghai suburb
Authors: Y.Q. Jiang, Y.X. Zhu, X.L. Chen, X. Xu, F. Li, H.J. Fu, C.Y. Shen, Y.Y. Lu, Q.J. Zhuang, G. Xu, Y.Y. Cai, Y. Zhang, S.S. Liu, M.Y. Zhu and S.H. Li
We performed a 1-year cluster-randomized field trial to assess the effect of standardized management of chronic obstructivepulmonary disease (COPD) on lung function and quality of life (QOL) measures in patients in China. We used the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines and assessed indexes including pulmonary.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.9
- DOI:
- 10.4238/2015.August.3.9
Transthoracic closure of atrial septal defect and ventricular septal defect without cardiopulmonary bypass
Authors: L. Wan,B.-T. Yu,Q.-C. Wu,L. Zeng,Q. Wang,J. Tang,Q.-R. Xu,H. Xu,W.-J. Wang,Y.-P. Cao and J.-C. Liu
The minimally invasive surgical transthoracic occlusion of an atrial septal defect (ASD) or a ventricular septal defect (VSD) is an increasingly widespread alternative treatment for congenital heart disease. The aim of this study is to summarize our clinical experience with minimally invasive surgical transthoracic occlusion of ASD and VSD without cardiop.. Read More»
- Genet. Mol. Res. 14(2):
- http://dx.doi.org/2015.April.22.4
- DOI:
- http://dx.doi.org/10.4238/2015.April.22.4
Pdxl and its role in activating Ngn3 and Pax6 to induce differentiation of iPSCs into islet �² cells
Authors: Y. Qin, L. Xiao, X.B. Zhan and H.X. Zhou
The pancreatic and duodenal homeobox factor 1 (Pdx1) protein is the most pivotal transcription factor in the development of islet β cells. This study investigated the role of Pdx1 and its mechanism in differentiating induced pluripotent stem cells (iPSCs) into islet β cells. iPSCs derived from human skin fibroblasts were cultured in vitro and di.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.12
- DOI:
- 10.4238/2015.August.3.12
Prediction of industrial tomato hybrids from agronomic traits and ISSR molecular markers
Authors: A.S.T. Figueiredo, J.T.V. Resende, M.V. Faria, P.R. Da-Silva, B.S. Fagundes and R.G.F. Morales
Heterosis is a highly relevant phenomenon in plant breeding. This condition is usually established in hybrids derived from crosses of highly divergent parents. The success of a breeder in obtaining heterosis is directly related to the correct identification of genetically contrasting parents. Currently, the diallel cross is th.. Read More»
- Genet. Mol. Res. 15(2):
- gmr.15027981
- DOI:
- 10.4238/gmr.15027981
Serum YKL-40 levels are associated with type 2 diabetes mellitus in patients with obstructive sleep apnea syndrome
Authors: L. Sun, J.Y. Liu and L.R. Li
Patients with obstructive sleep apnea syndrome (OSAS) have an increased risk for type 2 diabetes mellitus (T2DM). It has been recently demonstrated that serum YKL-40 levels, also named as human cartilage glycoprotein 39, are elevated in T2DM patients. The aim of this study was to determine whether serum YKL-40 levels are associated with T2DM in patients w.. Read More»
- Genet. Mol. Res. 14(3):
- 2015.August.3.15
- DOI:
- 10.4238/2015.August.3.15